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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Tumor Immunopharmacology, 2nd Edition

edited by

Marco A. Velasco-Velázquez

and

Nohemí Salinas-Jazmín

submission deadline 27 Apr 2026 | Viewed by 59 | Submission Open

Keywords: immunotherapy; immunomodulation; drug development; cytokine receptor antagonist; T-cell based therapies; therapeutic antibodies; drug delivery; cancer vaccine; immunoresistance; tumor-infiltrating lymphocytes (TILs); immune escape; immune checkpoint inhibitors; cytokine-based therapies; small molecule immunomodulators; combination therapy; precision oncology; tumor mutational burden (TMB); antibody-dependent cellular cytotoxicity (ADCC ); complement-dependent cytotoxicity (CDC); myeloid-derived suppressor cells (MDSCs)

(This special issue belongs to the Section Pharmacology)

Advances in Medicinal Chemistry: 2nd Edition

edited by

Mary J. Meegan

submission deadline 30 Apr 2026 | 3 articles | Viewed by 3384 | Submission Open

Keywords: drug discovery; novel drug targets; drug discovery; drug design and development; synthetic methods for drugs; analytical methodologies; in silico screening; structure and ligand-based drug design; structure– activity relationships (SAR); drug metabolism

(This special issue belongs to the Section Medicinal Chemistry)

Pharmacological Activity and Application of Polyphenolic Compounds

edited by

Luís Silva

submission deadline 30 Apr 2026 | Viewed by 1070 | Submission Open

Keywords: phenolic compounds; biological potential; pharmacological activity; phenolic applications; health promoters; chronic diseases

(This special issue belongs to the Section Natural Products)

Effects of Drug Abuse and Its Consequences on Health

edited by

Diana Dias Da Silva

and

Marcelo Dutra Arbo

submission deadline 30 Apr 2026 | Viewed by 501 | Submission Open

Keywords: psychoactive substances; drug abuse; toxicological effects; neurotoxicity; substance use disorder; biomarkers of toxicity; public health impact; addiction mechanisms; harm reduction strategies; novel psychoactive substance (NPS)

(This special issue belongs to the Section Medicinal Chemistry)

Therapeutic Potential of Natural Plant-Derived Compounds in Glioblastoma and Other Brain Tumors

edited by

Agnieszka Nowacka

Ewa Aleksandra Ziółkowska

and

Daniela De Vita

submission deadline 30 Apr 2026 | Viewed by 136 | Submission Open

Keywords: glioblastoma; GBM; brain tumors; natural plant‑derived compounds; phytochemicals; blood– brain barrier; signaling targets; tumor microenvironment; therapeutic opportunities; targeted therapy

(This special issue belongs to the Section Natural Products)

Neuropharmacology of Plant Extracts and Their Active Compounds (Second Edition)

edited by

Angel Josabad Alonso-Castro

submission deadline 30 Apr 2026 | Viewed by 115 | Submission Open

Keywords: medicinal plant; mental disorder; preclinical; clinical

(This special issue belongs to the Section Natural Products)

New Trends in the Treatment of Neuropsychiatric Disorders

edited by

Terezia Kiskova-Simkova

and

Aneta Bednarova

submission deadline 30 Apr 2026 | Viewed by 78 | Submission Open

Keywords: treatment; depression; schizophrenia; bipolar disorder; Alzheimer’ s disease

(This special issue belongs to the Section Pharmacology)

Innovative Drug Delivery and Mitochondrial-Targeted Therapies

edited by José Antonio Jara Sandoval and Alfredo E. Molina-Berríos

submission deadline 30 Apr 2026 | Viewed by 77 | Submission Open

Keywords: drug delivery; mitochondrial-targeted therapies; mitochondrial dysfunction; novel formulations; therapeutic strategies; mitocans; targeting mitochondria

(This special issue belongs to the Section Pharmacology)

The Therapeutic Potential of Neurotrophin Signaling in Neurodegenerative Disorders

edited by Konstantina Chanoumidou,

Ioannis Charalampopoulos

and

Vasiliki Panagiotakopoulou

submission deadline 30 Apr 2026 | Viewed by 66 | Submission Open

Keywords: central nervous system; neurodegeneration; neuroinflammation; therapy; neurotrophin receptors; regeneration; myelination

(This special issue belongs to the Section Pharmacology)

Innovative Organic Synthesis Approaches in Drug Design and Development

edited by

Antonio Jiritano

and

Vincenzo Algieri

submission deadline 30 Apr 2026 | Viewed by 65 | Submission Open

Keywords: sustainable organic synthesis; green chemistry; drug design and development; non-traditional solvents; Lewis acid catalysis; catalytic methodologies; photoredox and electrochemical methods; medicinal chemistry innovation

(This special issue belongs to the Section Medicinal Chemistry)

Computational Predictions of Molecules with Potential Therapeutic Effects: 2nd Edition

edited by

Whelton Miller

submission deadline 30 Apr 2026 | Viewed by 31 | Submission Open

Keywords: biophysics; medicinal chemistry; drug discovery; molecular docking; molecular dynamics; structure-activity relationships; computer-aided drug design (CADD)

(This special issue belongs to the Section Pharmacology)

Ophthalmic Drugs and Pharmacology

edited by Christin Henein and Sahar Awwad

submission deadline 1 May 2026 | Viewed by 93 | Submission Open

Keywords: ophthalmic diseases; optic neuropathies; eye diseases; glaucoma; corneal disorders; retinal degeneration; ocular surface disease

(This special issue belongs to the Section Pharmacology)

Innovative Computational and Experimental Strategies in Antimicrobial Drug Discovery

edited by

Domiziana Masci

and

Usama Ammar

submission deadline 10 May 2026 | Viewed by 34 | Submission Open

Keywords: antimicrobial resistance; multidrug resistance; small molecules; novel antimicrobial entities; in silico drug discovery; in vitro screening; innovative strategies; drug repurposing; structure– activity relationship; rational drug design

(This special issue belongs to the Section Medicinal Chemistry)

Allosteric Drug Design in the AI Era

edited by Lydia Siragusa and

Antonella Ciancetta

submission deadline 15 May 2026 | Viewed by 73 | Submission Open

Keywords: allosteric modulation; artificial intelligence in drug discovery; computational pharmacology; allosteric sites prediction; structure-based drug design

(This special issue belongs to the Section AI in Drug Development)

Metals in Cancer Research: Beyond Platinum Metallodrugs

edited by

Wukun Liu

and

Zhongren Xu

submission deadline 15 May 2026 | Viewed by 36 | Submission Open

Keywords: anticancer drugs; metal complexes; non-platinum; drug resistance; targeted therapy

(This special issue belongs to the Section Medicinal Chemistry)

Novel Drug Compositions for Ischemic Stroke: Mechanisms and Clinical Applications

edited by

Jasenka Mrsic-Pelcic

and

Anja Harej Hrkać

submission deadline 20 May 2026 | 1 articles | Viewed by 1896 | Submission Open

Keywords: ischemic stroke; novel delivery systems; nanomedicine; nanotechnology; neuroregenerative therapy; neurorepair; new and emerging treatments; pharmacotherapy; tissue engineering

(This special issue belongs to the Section Pharmacology)

Solid State Chemistry and Materials Science in Pharmaceutical Research: From Solid Forms to Advanced Dosage Forms

edited by Norbert Nagel, Wenqian Chen and Raimundo Ho

submission deadline 20 May 2026 | Viewed by 131 | Submission Open

Keywords: solid forms; solid form screening; pharmaceutical salts; polymorphism; hydrates; co-crystals; materials science; manufacturing process understanding; solid dosage forms; semi-solid dosage forms; pharmaceutical amorphous solid dispersions; enabling formulations; crystal structure prediction; material science tetrahedron; computational chemistry; structure-property relationships

(This special issue belongs to the Section Pharmaceutical Technology)

Artificial Intelligence-Assisted Drug Discovery

edited by Aldo Sena De Oliveira

submission deadline 25 May 2026 | 2 articles | Viewed by 9513 | Submission Open

Keywords: artificial intelligence; drug discovery; machine learning; medicinal chemistry; computational chemistry; virtual screening; ADMET predictions; de novo drug design; multi-target ligands; drug repositioning

(This special issue belongs to the Section Medicinal Chemistry)

Therapeutic Methods Against Acute and Chronic Diseases and Oxidative Stress

edited by

Yanka Karamalakova

submission deadline 25 May 2026 | 3 articles | Viewed by 7384 | Submission Open

Keywords: natural antioxidant; synthetic agents; acute diseases; chronic diseases; oxidative stress

(This special issue belongs to the Section Medicinal Chemistry)

The Therapeutic Potential of Cannabidiol

edited by

Karolina Walczyńska-Dragon

and

Anna Kurek-Górecka

submission deadline 25 May 2026 | 1 articles | Viewed by 3327 | Submission Open

Keywords: cannabidiol; endocannabinoid system; pain; anti-inflammatory agents; muscle spasticity; pain management; chronic pain

(This special issue belongs to the Section Natural Products)

Sirtuins as Novel Biological Targets for Pharmacological Intervention in Physiology and Pathology—2nd Edition

edited by

Michele Aventaggiato

and

Marco Tafani

submission deadline 25 May 2026 | 3 articles | Viewed by 2491 | Submission Open

Keywords: sirtuins; metabolism; cancer; hypoxia; damage recovery; cell death

(This special issue belongs to the Section Pharmacology)

Innovations in Therapeutic Strategies for Retinal and Neurodegenerative Diseases

edited by

Tonking Bastola

and Won-Kyu Ju

submission deadline 25 May 2026 | 1 articles | Viewed by 2324 | Submission Open

Keywords: glaucoma; Alzheimer's diseases; retinal disease; neuroprotection; neuroinflammation

(This special issue belongs to the Section Pharmacology)

Metal Complexes in Medicinal Chemistry: From Coordination Chemistry to Pharmaceutical Applications

edited by

Laura Rodriguez-Silva

and Cristina Núñez González

submission deadline 25 May 2026 | 1 articles | Viewed by 535 | Submission Open

Keywords: medicinal inorganic chemistry; metallodrugs; coordination compounds; bioinorganic chemistry; anticancer agents; antimicrobial agents; therapeutic applications; diagnostic applications; bioactive metal complexes; drug development

(This special issue belongs to the Section Medicinal Chemistry)

Antidiabetic Agents: New Drug Discovery Insights and Prospects

edited by Rosanna Maccari

submission deadline 25 May 2026 | Viewed by 152 | Submission Open

Keywords: diabetes mellitus; drug design; drug discovery; drug development; drug synthesis; computational-aided drug design; molecular targets; biological activity; structure– activity relationships

(This special issue belongs to the Section Medicinal Chemistry)

Research Advances in Targeted Therapy for Facial Skin Diseases

edited by

Edileia Bagatin

Marco Alexandre Rocha

and Diogo Pazzini Bomfim

submission deadline 25 May 2026 | Viewed by 78 | Submission Open

Keywords: facial dermatoses; targeted therapy; biologics; precision dermatology; acne vulgaris; topical drug delivery

(This special issue belongs to the Section Pharmacology)

Natural Products in Diabetes Mellitus: 3rd Edition

edited by

Ana Angelica Feregrino-Perez

submission deadline 25 May 2026 | Viewed by 64 | Submission Open

Keywords: natural products; hypoglycemia; phenolic compounds; diabetes mellitus; therapeutic; ROS

(This special issue belongs to the Section Natural Products)

Deregulated Signaling Pathways and Innovative Therapeutic Approaches in Cancer

edited by

Sofia Georgiou-Siafis

and Ioannis S. Pappas

submission deadline 25 May 2026 | Viewed by 57 | Submission Open

Keywords: anti-cancer therapeutic approaches; innovative therapeutics; molecular biology; deregulated signaling pathways; oncogenes; tumor repressor partners; antioxidant mechanisms; mAbs; targeted therapies

(This special issue belongs to the Section Pharmacology)

Impact of Drug Transporter Gene Variation on Pharmacokinetics and Clinical Outcomes in Chronic Disease Therapy

edited by

Fernando De Andrés

and

Pedro Dorado

submission deadline 25 May 2026 | Viewed by 55 | Submission Open

Keywords: drug transporter gene variants; chronic diseases; pharmacokinetics; clinical therapeutic effects; individualized medication; ABCB1; SLC22A family; SLCO1B1

(This special issue belongs to the Section Pharmacology)

Natural Bioactive Substances: Microencapsulation Technologies, Pharmacological Efficacies and Sustainable Application in Pharmaceuticals

edited by

Lauryna Pudžiuvelytė

and

Mantas Stankevičius

submission deadline 25 May 2026 | Viewed by 52 | Submission Open

Keywords: natural bioactive substances; microencapsulation technologies; pharmacological efficacy; sustainable pharmaceutical application; drug carrier materials; bioavailability; controlled release; green pharmacy

(This special issue belongs to the Section Pharmaceutical Technology)

Hepatitis B and Delta Virus Infections: Mechanistic Insights and Clinical Drug Therapy

edited by Daniele Lombardo

submission deadline 25 May 2026 | Viewed by 49 | Submission Open

Keywords: chronic hepatitis B; hepatitis delta virus coinfection; hepatocellular carcinoma risk; antiviral drug development; HBV functional cure strategies; immune modulation in hepatitis; pharmacological therapies for viral hepatitis

(This special issue belongs to the Section Pharmacology)

Peptide-Based Therapeutics: Targeting Amylin, Calcitonin, and Related Receptors

edited by

Sangmin Lee

and

Predrag Sikirić

submission deadline 25 May 2026 | Viewed by 33 | Submission Open

Keywords: GPCR; amylin; obesity; diabetes; peptide-based drugs; long-acting agonists

(This special issue belongs to the Section Biopharmaceuticals)

Advances in Solid-Phase Peptide and Oligonucleotide Synthesis: Methods, Mechanisms, and Therapeutic Applications

edited by

Danah AlShaer

and

Rakesh Tiwari

submission deadline 25 May 2026 | Viewed by 30 | Submission Open

Keywords: solid-phase peptide synthesis (SPPS); oligonucleotide synthesis; hybrid chemical– enzymatic methods; peptide therapeutics; drug design and discovery; sustainable synthesis; automation and process optimization; resin and linker chemistry; post-synthetic modification; structure– activity relationships

(This special issue belongs to the Section Biopharmaceuticals)

Histamine Receptors: Ligand Design, Pharmacology, and Therapeutic Applications

edited by

Marek Staszewski

and

Krzysztof Walczyński

submission deadline 25 May 2026 | Viewed by 29 | Submission Open

Keywords: histamine receptors; drug discovery; ligand design; antagonist/inverse agonist; pharmacology; therapeutic applications; multi-target directed ligands; molecular modeling

(This special issue belongs to the Section Pharmacology)

Development of Specific Dosage Form: Wound Dressing, 2nd Edition

edited by

Mihaela Violeta Ghica

Madalina Georgiana Albu Kaya

Lacramioara Popa

and Cristina Elena Dinu-Pirvu

submission deadline 25 May 2026 | Viewed by 25 | Submission Open

Keywords: skin lesion; wound healing; wound dressing; regenerative medicine; biomaterials; smart biopolymers; therapeutic system; controlled delivery system; scaffolds; biocompatibility

(This special issue belongs to the Section Pharmaceutical Technology)

Natural Products for Treating Hypertension and Blood Sugar

edited by

Arquimedes Gasparotto Junior

and

Emerson Luiz Botelho Lourenço

submission deadline 25 May 2026 | Viewed by 23 | Submission Open

Keywords: antihypertensive; diabetes; cardioprotective; herbal medicine; hypertension; medicinal plants; natural products

(This special issue belongs to the Section Natural Products)

DNA Repair Targeted Therapy: New Advances in Cancer Treatment

edited by Nimrat Chatterjee

submission deadline 25 May 2026 | Viewed by 9 | Submission Open

Keywords: DNA repair; cancer treatment; targeted therapy; gene-editing; immune-based therapies; DNA repair inhibitors; molecular targets; combination therapies

(This special issue belongs to the Section Biopharmaceuticals)

Computational Methods in Drug Development

edited by

Yunjie Zhao

submission deadline 26 May 2026 | 9 articles | Viewed by 21006 | Submission Open

Keywords: computational modeling; DNA/RNA and protein; drug discovery and design; systems biology; channels and membranes; biomedical data analysis; artificial intelligence; molecule docking and scoring

(This special issue belongs to the Section Medicinal Chemistry)

Sex Differences in Pharmaceutical Practice: 2nd Edition

edited by

Silvia De Francia

and

Sarah Allegra

submission deadline 28 May 2026 | Viewed by 41 | Submission Open

Keywords: sex; differences; drugs; kinetics; dynamics; preclinical; clinical; research

(This special issue belongs to the Section Medicinal Chemistry)

Pharmacotherapy of Dyslipidemias, 2nd Edition

edited by

Daniel Dias Rufino Arcanjo

and

Maria do Carmo de Carvalho e Martins

submission deadline 29 May 2026 | 3 articles | Viewed by 12254 | Submission Open

Keywords: atherosclerosis; dyslipidemia; endothelial dysfunction; fatty acids; high-fat diet; hyperlipidemia; hypertriglyceridemia; polyunsaturated fatty acids; PUFA; statins

(This special issue belongs to the Section Medicinal Chemistry)

Precision Oncology: Targeting Molecular Subtypes in Cancer Therapy

edited by

Shuhei Suzuki

and Jiro Ogura

submission deadline 29 May 2026 | 3 articles | Viewed by 2677 | Submission Open

Keywords: cancer chemotherapy; cancer genomic profiling test; next-generation sequencing; genetic variants; molecular targeted therapy; molecular tumor board; liquid biopsy

(This special issue belongs to the Section Pharmacology)

Exploring Novel Therapies and Drug Efficacy for Inflammatory Bowel Disease

edited by

Fabiana Andréa Moura

submission deadline 30 May 2026 | Viewed by 86 | Submission Open

Keywords: Crohn's disease; ulcerative colitis; pharmacology; antioxidants; novel therapies; gut microbiome; inflammation

(This special issue belongs to the Section Pharmacology)

Small-Molecule Inhibitors for Novel Therapeutics

edited by

Gustavo Provensi

and Simone Giovannuzzi

submission deadline 31 May 2026 | 4 articles | Viewed by 18252 | Submission Open

Keywords: small molecules; enzyme inhibition/activation; protein modulation; novel therapeutics; high-throughput screening; target proteins; drug delivery

Novel Anticancer Drug Development and Toxicity Reduction Strategies

edited by

Monika Papież

submission deadline 31 May 2026 | 3 articles | Viewed by 3205 | Submission Open

Keywords: cancer; targeted therapy; anticancer drug; structure-based computational technique; combination therapy; nanocarriers; hydrogels

(This special issue belongs to the Section Medicinal Chemistry)

Polymers, Nanoparticles and Hydrogels for Drug Delivery: Strategies and Applications

edited by Mónica de la Luz Corea Téllez, Marlon Rojas López,

Lucia Tellez-Jurado

and Rogelio Jiménez-Juárez

submission deadline 31 May 2026 | Viewed by 188 | Submission Open

Keywords: drug delivery; medical applications; hydrogels; polymers; nanoparticles; drug delivery system; multi-stimuli-responsive materials; nanocomposites; biofilms; biomarkers

(This special issue belongs to the Section Pharmaceutical Technology)

Applications of Stem Cells and Organoids in Disease Modeling, Drug Discovery and Clinical Evaluation

edited by Daniela Omodei

submission deadline 31 May 2026 | Viewed by 107 | Submission Open

Keywords: stem cells; patient-derived cells; iPSCs (induced pluripotent stem cells); organoids; drug development; drug screening; drug toxicity; preclinical and clinical drug research; novel therapeutics; disease modeling; personalized medicine; precision medicine

(This special issue belongs to the Section Pharmacology)

Advances in Theranostic Radiopharmaceuticals

edited by

Janke Kleynhans

submission deadline 31 May 2026 | Viewed by 101 | Submission Open

Keywords: theranostics; radiopharmacy; targeted alpha therapy; preclinical imaging; radiobiology; radioisotope production; molecular radiotherapy; positron emission tomography; single photon emission tomography

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Drug Candidates for the Treatment of Obesity, 3rd Edition

edited by

Maria Isabel Cardoso Alonso-Vale

and

Monica Marques Telles

submission deadline 31 May 2026 | Viewed by 48 | Submission Open

Keywords: obesity ; appetite supressors ; nutraceuticals ; plant extracts ; lipid metabolism ; high-fat diet ; adipogenesis

(This special issue belongs to the Section Medicinal Chemistry)

Targeting the NLRP3: From Novel Inhibitor Design to Clinic Trials and Therapeutic Applications

edited by

Yiming Xu

and

Yana Cen

submission deadline 31 May 2026 | Viewed by 46 | Submission Open

Keywords: NLRP3 inflammasome; selective and direct NLRP3 inhibitors; drug discovery; clinical trial; therapeutic applications

(This special issue belongs to the Section Biopharmaceuticals)

Pharmacological Treatments for Parasitic Diseases

edited by Maria Dichiara and

Giuliana Costanzo

submission deadline 31 May 2026 | Viewed by 25 | Submission Open

Keywords: parasitic diseases; antiparasitic agents; drug resistance; therapeutic strategies; drug discovery; neglected tropical diseases (NTDs); medicinal chemistry; global health

(This special issue belongs to the Section Medicinal Chemistry)

Anti-Fbibrosis Agent Development

edited by Younghwa Na

submission deadline 31 May 2026 | Viewed by 13 | Submission Open

Keywords: idiopathic pulmonary fibrosis (IPF); anti-fibrosis; drug discovery; combination therapies; personalized medicine

(This special issue belongs to the Section Medicinal Chemistry)

Displaying special issue 301-350 on page 7 of 8.

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