Special Issues

Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Antibiotic Resistance and Misuse submission deadline 31 Dec 2025 | 2 articles | Viewed by 10222 | Submission Open
Keywords: antibiotic resistance; antibiotic misuse; antimicrobial stewardship; infection control; resistance mechanisms; diagnostic innovations; therapeutic strategies; policy reforms; clinical outcomes
(This special issue belongs to the Section Pharmacology)
Pharmacology of Heart Failure submission deadline 31 Dec 2025 | 3 articles | Viewed by 8114 | Submission Open
Keywords: heart failure; pharmacological treatment; drug interactions; side effect; comorbidities
(This special issue belongs to the Section Pharmacology)
Heterocyclic Chemistry in Modern Drug Development submission deadline 31 Dec 2025 | 3 articles | Viewed by 6596 | Submission Open
Keywords: heterocycles; drug design; drug development; green synthesis; organic synthesis; synthetic biology; enzyme inhibitors; medicinal chemistry; cell biology; in vitro assay
(This special issue belongs to the Section Medicinal Chemistry)
Novel Heterocyclic Compounds as Potential Anti-Inflammatory and/or Anticancer Agents
edited by Ester Colarusso and
submission deadline 31 Dec 2025 | 1 articles | Viewed by 3921 | Submission Open
Keywords: drug discovery; medicinal chemistry; privileged scaffolds; heterocyclic compounds; anticancer activity; anti-inflammatory activity
(This special issue belongs to the Section Medicinal Chemistry)
Infectious Disease Epidemiology and Pharmaceutical Development in the Era of Antimicrobial Resistance (AMR)
edited by Victoria Birlutiu
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2878 | Submission Open
Keywords: antimicrobial resistance (AMR); antibiotic stewardship; multidrug-resistant organisms (MDROs); infectious disease epidemiology; rapid diagnostics; antimicrobial surveillance; therapeutic development; resistance mechanisms
(This special issue belongs to the Section Pharmacology)
PET/CT for Diagnosis, Treatment Planning and Prognosis Prediction in Oncology and Inflammatory Diseases submission deadline 31 Dec 2025 | 1 articles | Viewed by 2261 | Submission Open
Keywords: nuclear medicine; PET/CT; radiopharmaceuticals; theragnostics; oncology; inflammation; personalised medicine
(This special issue belongs to the Section Radiopharmaceutical Sciences)
Recent Strategies for Delivery of Plant-Based Active Ingredients submission deadline 31 Dec 2025 | 1 articles | Viewed by 2108 | Submission Open
Keywords: drug delivery; polymeric nanoparticles; lipid nanosystems; inclusion complexes; polymeric cyclodextrins; protein carriers; inorganic delivery systems; nanostructured carriers; chemical– physical characterization; in vitro/ex vivo/in vivo evaluation
(This special issue belongs to the Section Pharmaceutical Technology)
Next-Generation Antinfective Agents submission deadline 31 Dec 2025 | 1 articles | Viewed by 1833 | Submission Open
Keywords: small molecules; peptides; peptidomimetics; bacterial infections; fungi; virus; parasites; drug design; computational tools; biology assays; resistance mechanisms
(This special issue belongs to the Section Medicinal Chemistry)
Advancing Cardio-Oncology: Mechanisms of Cardiotoxicity and Therapeutic Options for Old and New Anticancer Drugs
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1524 | Submission Open
Keywords: cardio-oncology; anticancer therapies; cardiac dysfunction; hypertension; heart failure; intercellular communication; treatment; prevention; diagnosis; cardiac remodeling
(This special issue belongs to the Section Pharmacology)
Recent Advances in the Research of Drug Delivery System: Materials, Preparation Methods, and Mechanisms
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1438 | Submission Open
Keywords: drug delivery system; preparation; material; mechanism; application; bioactivities; targeted delivery
(This special issue belongs to the Section Pharmaceutical Technology)
Applications of Nerve Growth Factor in Pharmaceuticals
edited by and Antonio Chiaretti
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1389 | Submission Open
Keywords: nerve growth factor; neurotrophins; neuroplasticity; brain injury; neuronal survival
(This special issue belongs to the Section Pharmacology)
New Perspective on Bioactive Peptides from Natural Sources: Current Applications and Future Directions submission deadline 31 Dec 2025 | 1 articles | Viewed by 1336 | Submission Open
Keywords: bioactivity; bioassays; bioproducts; functional foods; immunogenicity; nutraceuticals; pharmacology; plant-derived peptides; skin secretion; toxicology; venom
Advances in Smooth Muscle Pharmacology
edited by , Tomasz Kleszczewski and
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1126 | Submission Open
Keywords: smooth muscle regulation; pharmacological interventions; ion channel modulation; receptor– ligand dynamics; therapeutic drug development; vascular tone regulation; smooth muscle disorders; translational pharmacology; cellular signaling pathways; pathophysiology
(This special issue belongs to the Section Pharmacology)
Advances in Regulatory Mechanisms and Therapeutic Potential of Non-Coding RNAs in Neurodegenerative Diseases
edited by and Maurizio Grassano
submission deadline 31 Dec 2025 | 1 articles | Viewed by 767 | Submission Open
Keywords: non-coding RNAs; microRNAs; long non-coding RNAs; circular RNAs; neurodegeneration; Alzheimer's disease; Parkinson's disease; amyotrophic lateral sclerosis; gene regulation; biomarkers; RNA therapeutics; neuroinflammation; synaptic dysfunction; translational neuroscience
(This special issue belongs to the Section Biopharmaceuticals)
Green Synthesis and Biological Evaluation of Nitrogen-Containing Heterocycles
edited by Mario Komar, and
submission deadline 31 Dec 2025 | 1 articles | Viewed by 750 | Submission Open
Keywords: N-containing heterocycles; microwave-assisted synthesis; ultrasound-assisted synthesis; mechanochemical synthesis; deep eutectic solvents; biomass-derived solvents; biological evaluation; computational methods
(This special issue belongs to the Section Medicinal Chemistry)
Advances in Enzyme Inhibitors and Protein Degraders as Anticancer Agents
edited by and
submission deadline 31 Dec 2025 | 1 articles | Viewed by 592 | Submission Open
Keywords: anticancer agents; mechanism of action; epigenetics; PROTAC; antibody– drug conjugates; enzymes
(This special issue belongs to the Section Medicinal Chemistry)
New Perspective on Natural Compounds for the Prevention and Treatment of Cardiovascular Diseases submission deadline 31 Dec 2025 | Viewed by 266 | Submission Open
Keywords: bioactivity; synthesis; pharmacology; natural compounds; natural product; cardiovascular diseases
Novel Developments in Antileishmanial and Antitrypanosomal Agents
edited by , Guillermo Labadie and Brian Suárez Mantilla
submission deadline 31 Dec 2025 | Viewed by 238 | Submission Open
Keywords: antileishmanial; antitrypanosomal; Chagas disease; human African Trypanosomiasis (sleeping sickness); leishmaniasis; drug discovery; medicinal chemistry; natural products; drug repurposing; trypanosomatids
(This special issue belongs to the Section Medicinal Chemistry)
Natural and Synthetic Bioactive Products for Treatment of Immune-Mediated Diseases submission deadline 31 Dec 2025 | Viewed by 175 | Submission Open
Keywords: diabetes; cancer; diarrhea; viral infections; bacterial infections; fungical infections; drug development; medicinal chemistry; phytochemistry; pharmacognosy; synthesis
(This special issue belongs to the Section Natural Products)
Microemulsion and Nanoemulsion: Concepts, Development and Applications in Drug Delivery submission deadline 31 Dec 2025 | Viewed by 131 | Submission Open
Keywords: microemulsions (MEs); nanoemulsions (NEs); drug delivery
(This special issue belongs to the Section Pharmaceutical Technology)
Immunomodulatory Drugs for Autoimmune Diseases: Mechanisms, Development and Clinical Translation
edited by Patricia Fanlo-Mateo
submission deadline 1 Jan 2026 | Viewed by 159 | Submission Open
Keywords: autoimmune diseases; immunomodulatory drugs; biologic therapies; immunosupressants; immunotherapy; drug repurposing
(This special issue belongs to the Section Medicinal Chemistry)
Emerging Therapies for Diabetes and Obesity
edited by Pedro Cisternas
submission deadline 15 Jan 2026 | 5 articles | Viewed by 5782 | Submission Open
Keywords: insulin resistance; adipose tissue dysfunction; antidiabetic agents; metabolic disease; metabolic inflammation; pharmacological interventions
(This special issue belongs to the Section Pharmacology)
The Pharmacology of Bisphosphonates: New Advances submission deadline 20 Jan 2026 | 6 articles | Viewed by 10775 | Submission Open
Keywords: bisphosphonates; bisphosphonic acids; pharmacology of bisphosphonates; pharmacokinetics; pharmacodynamics; hypocalcemia; osteonecrosis; gastrointestinal disturbances; delivery systems of bisphosphonates; bisphosphonate prodrugs; osteoporosis; breast cancer; prostate cancer; hypercalcemia; antiresorptive properties; antibacterial properties; anti-cancer properties; antiparasitic activity; antiprotozoal properties; antiviral properties; effects of drugs on the metabolism and biomechanical properties of bone tissue; properties and effects of bisphosphonates in in vitro and/or in vivo experimental models of bone disorders; different bisphosphonates in an in vitro experimental model of bone disease
(This special issue belongs to the Section Pharmacology)
Pharmacological Activities and Therapeutic Potential of Novel Drug Derivatives submission deadline 20 Jan 2026 | 2 articles | Viewed by 7519 | Submission Open
Keywords: novel drug derivatives; synthesis; drug design; therapeutic potential; biological activity; pharmacological activity
(This special issue belongs to the Section Pharmacology)
Biological and Pharmacological Research on Indole-3-Carbinol (I3C) and Its Derivatives submission deadline 20 Jan 2026 | 3 articles | Viewed by 5545 | Submission Open
Keywords: indole-3-carbinol; natural and synthetic derivatives of I3C; synthetic procedures; biosynthetic processes; in vitro; in vivo and clinical studies; mechanism of action; biological properties; pharmacological properties; potential therapeutic applications in health and disease
(This special issue belongs to the Section Pharmacology)
Interdisciplinary Approaches to Preventing and Treating Inflammatory and Oxidative Diseases with Medicinal Plants and Bioactive Compounds submission deadline 20 Jan 2026 | 1 articles | Viewed by 5308 | Submission Open
Keywords: interdisciplinary studies; inflammation; inflammatory diseases; oxidative stress; oxidative diseases; pro-inflammatory; pro-oxidative; neurodegenerative diseases; cardiovascular diseases; cancer; medicine; rheumatological diseases; endocrinological diseases; gastroenterological diseases; dermatological diseases; pulmonary diseases; dentistry; nutrition; dietetics; therapy; medicinal plants; bioactive compounds; phytochemicals; phytochemistry
(This special issue belongs to the Section Natural Products)
Resveratrol: Pharmacological Mechanisms and Therapeutic Potential as a Natural Product submission deadline 20 Jan 2026 | Viewed by 1094 | Submission Open
Keywords: resveratrol; natural compound pharmacology; therapeutic potential; drug development; biomedical research
(This special issue belongs to the Section Natural Products)
Pharmacotherapeutics of Sarcoidosis
edited by , and Giorgio Monteleone
submission deadline 20 Jan 2026 | 1 articles | Viewed by 608 | Submission Open
Keywords: sarcoidosis; drug combinations; interstitial lung disease; biological therapy; target therapy; biomarkers
(This special issue belongs to the Section Pharmacology)
Pharmacoepidemiology and Pharmacovigilance in Drug Therapy: New Issues, Challenges, and Applications
edited by Loreta KubilienÄ—
submission deadline 25 Jan 2026 | 6 articles | Viewed by 14468 | Submission Open
Keywords: pharmacoepidemiology; pharmacovigilance; drug safety monitoring; regulatory practices; hospitalization; adverse drug events; drug safety; preventability
(This special issue belongs to the Section Pharmacology)
A Commemorative Special Issue in Honor of Professor Carlos Alberto Manssour Fraga: Medicinal Chemistry’s Efforts to Discover Novel Bioactive Molecules for Complex Diseases submission deadline 25 Jan 2026 | 7 articles | Viewed by 14451 | Submission Open
Keywords: medicinal chemistry; bioactive molecules; complex diseases; cardiovascular diseases; diabetes; cancer; neurodegenerative disorders; drug discovery; synthetic chemistry; target identification; structure– activity relationship; preclinical evaluation
(This special issue belongs to the Section Medicinal Chemistry)
The Application of Pharmacogenetics in Toxicity Prevention and Drug Effect Improvement
edited by Pura Ballester
submission deadline 25 Jan 2026 | 5 articles | Viewed by 14214 | Submission Open
Keywords: pharmacogenetics; drug toxicity prevention; efficacy enhancement; pharmaceutical research; precision medicine; therapeutic optimization
(This special issue belongs to the Section Pharmacology)
2D and 3D Culture Systems: Current Trends and Biomedical Applications
edited by , Colus Ilce Mara and
submission deadline 25 Jan 2026 | 6 articles | Viewed by 10745 | Submission Open
Keywords: spheroids; organoids; 3D cultures; tissue engineering; disease modelling; regenerative medicine; cell-extracellular matrix interaction; drug screening
(This special issue belongs to the Section Biopharmaceuticals)
Clinical Advances in the Neuropharmacological Treatment of Substance Use Disorders: 2nd Edition
edited by
submission deadline 25 Jan 2026 | 2 articles | Viewed by 4166 | Submission Open
Keywords: neuropharmacology; drug abuse; addiction; substance abuse
(This special issue belongs to the Section Pharmacology)
Advances in Hybrid Anticancer Drugs: Innovations and Therapeutic Potential
edited by
submission deadline 25 Jan 2026 | 2 articles | Viewed by 2711 | Submission Open
Keywords: drug design; molecular hybrids; anticancer agents; privileged scaffold; multiple mechanisms of action
(This special issue belongs to the Section Medicinal Chemistry)
Recent Research in Therapeutic Potentials of Venoms
edited by Samuel Teixeira, Daiana Silva Lopes and
submission deadline 25 Jan 2026 | 2 articles | Viewed by 2221 | Submission Open
Keywords: bioprospecting; biotechnological tools; snake venom toxins; drug discovery; natural products; pharmacological applications; molecular targets of venom toxins; toxicology; peptide therapeutics; venom-based drug delivery
(This special issue belongs to the Section Natural Products)
Anti-Inflammatory and Antithrombotic Natural Bioactives for Drug Development: Current Status and Future Perspectives submission deadline 25 Jan 2026 | 1 articles | Viewed by 1951 | Submission Open
Keywords: chronic disorders; bioactives; natural sources; sustainable sources; pharmaceuticals; drug discovery; structure– activity relationship; synergism; health promotion; bio-functional; drugs; inflammation; thrombosis; platelets; cancer; CVD; neurodegenerative; neuroprotective; anti-inflammatory; cardio-protective; anti-cancer; anti-tumor; anti-thrombotic; antiplatelet; anticoagulant
(This special issue belongs to the Section Natural Products)
Dysregulation of Cyclic AMP and Cyclic PIP Synthesis: Implications for Disease and Advances in Therapeutic Development
edited by
submission deadline 25 Jan 2026 | 1 articles | Viewed by 720 | Submission Open
Keywords: reversible protein phosphorylation; cyclic AMP; cyclic PIP; signal transduction; cyclic AMP antagonist
(This special issue belongs to the Section Medicinal Chemistry)
Therapeutic Drug Monitoring: Techniques and Applications in Pharmaceutical Analysis
edited by Ivana Cizmarova and
submission deadline 25 Jan 2026 | 1 articles | Viewed by 622 | Submission Open
Keywords: Therapeutic Drug Monitoring (TDM); bioanalytical method development; LC-MS/MS; sample preparation; method validation; pharmacokinetics; pharmacodynamics; individualized dosing; precision medicine; clinical applications
Therapeutic Potential of Aldehyde Dehydrogenases submission deadline 25 Jan 2026 | Viewed by 599 | Submission Open
Keywords: ALDH; cancer; cancer stem cells; diabetes; Parkinson’ s disease; Alzheimer’ s disease; ALDH inhibitors; ALDH signaling; CSC-based therapeutics; therapeutic strategies
(This special issue belongs to the Section Medicinal Chemistry)
Research Progress and Drug Intervention Strategies for Oral Health-Related Diseases
edited by and Mariana Pacurar
submission deadline 25 Jan 2026 | Viewed by 317 | Submission Open
Keywords: oral health; dental caries; periodontal diseases; drug intervention; biomaterials; biomarkers; microbiome; pharmacogenomics; targeted therapy; oral drug delivery; oral disease prevention
(This special issue belongs to the Section Pharmacology)
Advances in Drug Treatment for Pediatric Gastroenterology
edited by Roxana Elena Matran, Iulia Florentina Ţincu and
submission deadline 25 Jan 2026 | Viewed by 244 | Submission Open
Keywords: biologics; Crohn’ s disease; ulcerative colitis; eosinophilic esophagitis; autoimmune hepatitis; probiotics; inflammatory bowel disease
(This special issue belongs to the Section Pharmacology)
Gut Microbiota Modulation: Probiotics, Postbiotics and Other Bioactive Compounds—2nd Edition submission deadline 25 Jan 2026 | Viewed by 197 | Submission Open
Keywords: gut microbiota; bioactive compounds; immune system; nutrition respiratory health
Design, Synthesis and Evaluation of Novel 18F Radiotracers
edited by and John E. Shively
submission deadline 25 Jan 2026 | Viewed by 193 | Submission Open
Keywords: positron emission tomography (PET); fluorine-18 (F-18); radiotracer development; molecular imaging; non-invasive diagnostic technique; synthetic methodologies; preclinical evaluation
(This special issue belongs to the Section Radiopharmaceutical Sciences)
Pharmacogenomics and Ethnic Diversity: Optimizing Drug Response Across Populations
edited by and Gisely Cardoso De Melo
submission deadline 25 Jan 2026 | Viewed by 169 | Submission Open
Keywords: pharmacogenomics; pharmacogenetics; ethnic groups; population genetics; ancestry; drug response
(This special issue belongs to the Section Pharmacology)
Current Advances, Applications and Future Development of Transition Metal Complexes, 2nd Edition
edited by
submission deadline 25 Jan 2026 | Viewed by 136 | Submission Open
Keywords: transition metal complexes; synthesis; catalysis; ligands; biological activity; applications; enzyme inhibition
(This special issue belongs to the Section Medicinal Chemistry)
Pharmacotherapy of Inflammatory Bowel Disease, 2nd Edition
edited by
submission deadline 25 Jan 2026 | Viewed by 131 | Submission Open
Keywords: treatment of Crohn's Disease; treatment of ulcerative colitis; mesalamine for ulcerative colitis; mesalamine for Crohn's Disease; antibody strategies in IBD; small molecules for IBD; conservative management of Crohn's fistula; therapy for extraintestinal manifestations; new endpoints for treatment
(This special issue belongs to the Section Pharmacology)
Osteosarcomas: Treatment Strategies, 2nd Edition
edited by
submission deadline 26 Jan 2026 | 3 articles | Viewed by 9834 | Submission Open
Keywords: osteosarcoma; anti-cancer; apoptosis; natural compounds; target; drug
(This special issue belongs to the Section Pharmacology)
Advances in Drug Analysis and Drug Development, 2nd Edition
edited by and Ana Mornar
submission deadline 26 Jan 2026 | 3 articles | Viewed by 2284 | Submission Open
Keywords: analytical methodology; chromatographic techniques; spectrometric techniques; thermal analysis techniques; sample preparation; drug stability; compatibility study; bioavailability studies; therapeutic drug monitoring; quality by design in pharmaceutical analysis
(This special issue belongs to the Section Pharmaceutical Technology)
Pharmacological Modulation of Inflammation in Autoimmune Diseases and Cancer submission deadline 27 Jan 2026 | 1 articles | Viewed by 2842 | Submission Open
Keywords: microenvironment; TRAP; NET; tumor niche; exosomes; neuromodulation of tumor growth; autoimmune diseases; pharmacology; biomarkers
(This special issue belongs to the Section Pharmacology)
Innovative Drug Strategies in Chronic Disease Management: Addressing Non-Adherence and Improving Therapeutic Outcomes submission deadline 27 Jan 2026 | 2 articles | Viewed by 2384 | Submission Open
Keywords: adherence; persistence; chronic diseases; therapeutic strategies; individualized therapy; personalized medicine; clinical pharmacology; clinical trials; observational studies; real-world data studies
(This special issue belongs to the Section Pharmacology)
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