Applications of Nerve Growth Factor in Pharmaceuticals

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 555

Special Issue Editors


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Guest Editor
Institute of Pediatrics, Fondazione Policlinico A. Gemelli IRCCS, 00168 Rome, Italy
Interests: nerve growth factor; neurotrophins; neuroplasticity; neuronal survival; traumatic brain injury; pediatrics; pediatric emergency medicine; POCUS; clinical trials in pediatrics; point of care ultrasound; lung ultrasound; pediatric epidemiology; global health

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Guest Editor
Institute of Pediatrics, Fondazione Policlinico A. Gemelli IRCCS, Università Cattolica Sacro Cuore, 00168 Rome, Italy
Interests: nerve growth factor; neurotrophins; neuroplasticity; neuronal survival; traumatic brain injury; pediatrics; pediatric emergency medicine; clinical trials in pediatrics; children’s health; pediatric epidemiology; global health

Special Issue Information

Dear Colleagues,

Since the pioneering research of Nobel Laureate Rita Levi-Montalcini, nerve growth factor (NGF) has gained increasing attention in the scientific community as a promising candidate for the treatment of several human diseases. NGF has indeed been researched in relation to various neurological disorders, including hypoxic–ischemic encephalopathy, traumatic brain injury, neurobehavioral and neurodevelopmental diseases, congenital malformations, cerebral infections, as well as oncological and ocular diseases. The complex and sophisticated mechanisms by which NGF contributes to neuronal survival and regeneration, some of which are far from understood, represent a vast area of medical research. In recent years, there has been a proliferation of literature on this topic, both preclinical and clinical, with some brilliant results. However, despite the progress made, there are still some controversies regarding the most efficient method of administration and application strategy. A multimodal interdisciplinary approach, based on multiple levels of research and including translational studies, is needed to address the current challenges and to go beyond them through a comprehensive enrichment of new insights and knowledge. For this Special Issue, we hope that researchers from a variety of disciplines will consider contributing.

Dr. Lorenzo Di Sarno
Prof. Dr. Antonio Chiaretti
Guest Editors

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Keywords

  • nerve growth factor
  • neurotrophins
  • neuroplasticity
  • brain injury
  • neuronal survival

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Published Papers (1 paper)

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Review

16 pages, 815 KiB  
Review
Nerve Growth Factor in Pediatric Brain Injury: From Bench to Bedside
by Lorenzo Di Sarno, Serena Ferretti, Lavinia Capossela, Antonio Gatto, Valeria Pansini, Anya Caroselli, Luigi Manni, Marzia Soligo and Antonio Chiaretti
Pharmaceuticals 2025, 18(6), 929; https://doi.org/10.3390/ph18060929 - 19 Jun 2025
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Abstract
Background: Traumatic brain injury (TBI) and hypoxic–ischemic encephalopathy (HIE) are major causes of long-term neurological disability in children, with limited options for effective neuronal recovery. Recent research has highlighted the therapeutic potential of nerve growth factor (NGF) in promoting neural repair through mechanisms [...] Read more.
Background: Traumatic brain injury (TBI) and hypoxic–ischemic encephalopathy (HIE) are major causes of long-term neurological disability in children, with limited options for effective neuronal recovery. Recent research has highlighted the therapeutic potential of nerve growth factor (NGF) in promoting neural repair through mechanisms such as neuroprotection, neurogenesis, and the modulation of neuroinflammation. This review evaluates the current evidence on NGF as a treatment strategy for pediatric brain injury, emphasizing its mechanisms of action and translational clinical applications. Methods: A comprehensive review was conducted using the PubMed, Scopus, and Cochrane CENTRAL databases to identify studies published between 1 January 1978 and 1 March 2025, investigating NGF in the context of brain injury. The inclusion criteria comprised studies assessing neurological outcomes through clinical scales, biochemical markers, neuroimaging, or electrophysiological examinations. Results: Seventeen studies met the inclusion criteria, encompassing both preclinical and clinical research. Preclinical models consistently demonstrated that NGF administration reduces neuroinflammation, enhances neurogenesis, and supports neuronal survival following TBI and HIE. Clinical studies, including case reports of pediatric patients treated with intranasal NGF, reported improvements in motor and cognitive function, neuroimaging findings, and electrophysiological parameters, with no significant adverse effects observed. Conclusions: NGF demonstrates significant promise as a neuroprotective and neuroregenerative agent in pediatric brain injury, with both experimental and early clinical evidence supporting its safety and efficacy. Large-scale controlled clinical trials are warranted to validate these preliminary findings and to determine the optimal dosage regimens and administration schedules for NGF in the treatment of TBI and HIE. Full article
(This article belongs to the Special Issue Applications of Nerve Growth Factor in Pharmaceuticals)
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