Advancing Cardio-Oncology: Mechanisms of Cardiotoxicity and Therapeutic Options for Old and New Anticancer Drugs
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".
Deadline for manuscript submissions: closed (31 July 2025) | Viewed by 547
Special Issue Editor
Interests: cardiotoxicity; cardio-oncology; chemobrain; clinical toxicology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The incidence of cancer is growing worldwide and is projected to rise even further in the coming decades. Nonetheless, the life expectancy of cancer patients continues to improve due to advancements in early diagnosis and the development of both established and novel therapies. However, the cardiotoxicity associated with anticancer treatments, including traditional chemotherapy agents, targeted therapies, and emerging immunotherapies, remains a leading cause of death and morbidity in cancer patients. Drugs such as anthracyclines, HER2-targeted therapies, immune checkpoint inhibitors, and chimeric antigen receptor (CAR) T-cell therapies, while effective against cancer, are known to induce a range of cardiovascular toxicities, from arrhythmias and myocarditis to heart failure and vascular complications.
This growing burden underscores the critical importance of cardio-oncology as a focal clinical and scientific field. A major future challenge in cardiovascular medicine lies in elucidating the molecular and immunological mechanisms of cardiotoxicity associated with these therapies, enabling the development of more precise diagnostic tools, effective therapeutic strategies, and personalized approaches to mitigate risks.
It is for this reason that this Special Issue aims to bring together the latest findings in cardio-oncology, encompassing cell-based studies, preclinical and clinical investigations, case reports, and reviews. These contributions will highlight novel mechanisms underlying cardiac remodeling and dysfunction caused by anticancer therapies and explore innovative pharmacological and non-pharmacological solutions to address these challenges.
Dr. Vera Marisa Costa
Guest Editor
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Keywords
- cardio-oncology
- anticancer therapies
- cardiac dysfunction
- hypertension
- heart failure
- intercellular communication
- treatment
- prevention
- diagnosis
- cardiac remodeling
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