Interdisciplinary Approaches to Preventing and Treating Inflammatory and Oxidative Diseases with Medicinal Plants and Bioactive Compounds

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Natural Products".

Deadline for manuscript submissions: 15 August 2025 | Viewed by 743

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Department of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, SP, Brazil
Interests: medicinal plants; bioactive compounds; phytochemicals; phytochemistry; cancer; metabolism; metabolic disorders; pharmacology; inflammation; oxidative stress; cardiovascular diseases; neurodegenerative diseases
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Special Issue Information

Dear Colleagues,

We would like to welcome you to contribute a paper to our Special Issue, with the utmost pride and deepest gratitude. Using an interdisciplinary, holistic view, this Special Issue delves into preventing and intervening in inflammatory and oxidative diseases using medicinal plants and bioactive compounds. Uncontrolled inflammation and oxidative stress are detrimental to the body’s homeostasis, leading to various diseases. Since ancient times, medicinal plants and phytochemicals have been used to treat multiple diseases, including those neurodegenerative and cardiovascular, as well as cancer and others. Medicinal plants and phytochemicals may be more cost-effective and present few adverse events, promoting synergism with conventional therapies. In today’s world, therapy often predisposes patients to be treated by multiple professionals who must work together to maintain results and rehabilitate patients. However, medicinal plants and phytochemicals are not as well funded by various medical specialties and other professions. Therefore, the main aim of this Special Issue is to contribute to the existent foundation regarding the use of medicinal plants and phytochemicals against multiple diseases and health conditions, especially those diseases which oblige patients to attend various medical specialties and professions, offering to you, erudite Authors, the challenge of proposing special studies in the field to promote a healthier, less-diseased future. We welcome original research studies and review articles. Translational research in the field is also welcome.

We appreciate your interest in our Special Issue and look forward to receiving your papers. Your contributions will make this project a success!

Dr. Lucas Fornari Laurindo
Dr. Sandra Barbalho
Guest Editors

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Keywords

  • interdisciplinary studies
  • inflammation
  • inflammatory diseases
  • oxidative stress
  • oxidative diseases
  • pro-inflammatory
  • pro-oxidative
  • neurodegenerative diseases
  • cardiovascular diseases
  • cancer
  • medicine
  • rheumatological diseases
  • endocrinological diseases
  • gastroenterological diseases
  • dermatological diseases
  • pulmonary diseases
  • dentistry
  • nutrition
  • dietetics
  • therapy
  • medicinal plants
  • bioactive compounds
  • phytochemicals
  • phytochemistry

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Published Papers (1 paper)

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26 pages, 6502 KiB  
Systematic Review
Investigating the Health Potential of Mentha Species Against Gastrointestinal Disorders—A Systematic Review of Clinical Evidence
by Mariana Hirata, Lucas Fornari Laurindo, Victória Dogani Rodrigues, Flávia Cristina Castilho Caracio, Vitor Engrácia Valenti, Eliana de Souza Bastos Mazuqueli Pereira, Rodrigo Haber Mellem, Cláudia Rucco Penteado Detregiachi, Manuela dos Santos Bueno, Leila Maria Guissoni Campos, Caio Sérgio Galina Spilla and Sandra Maria Barbalho
Pharmaceuticals 2025, 18(5), 693; https://doi.org/10.3390/ph18050693 - 8 May 2025
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Abstract
Background/Objectives: Gastrointestinal disorders include a broad spectrum of clinical conditions due to various symptoms. Abdominal pain claims attention as it can be associated with multiple diseases, and some of them can lead to chronic abdominal pain, such as chronic gastritis and irritable bowel [...] Read more.
Background/Objectives: Gastrointestinal disorders include a broad spectrum of clinical conditions due to various symptoms. Abdominal pain claims attention as it can be associated with multiple diseases, and some of them can lead to chronic abdominal pain, such as chronic gastritis and irritable bowel syndrome. Moreover, dyspepsia is also a prevalent condition, and its symptoms are postprandial fullness, epigastric pain or burn, and early satiety. Conventional therapeutic approaches for gastrointestinal disorders exist, but the Mentha plant has a millenary tradition. Mentha aerial parts and leaves hold therapeutic and pharmacological value, and its components are characterized as non-essential oil with superabundant phenolic compounds, and essential oil classified as volatile secondary metabolites like menthol and menthone. Studies have shown that Mentha species can exert benefits by modulating the inflammatory process and scavenging free radicals, which can benefit gastrointestinal tract disorders. The aim of this review was to systematically investigate the effects of Mentha species on gastrointestinal disorders. Methods: Sixteen clinical trials included patients diagnosed with irritable bowel syndrome, functional dyspepsia, and functional abdominal pain, as well as some healthy volunteers. The COCHRANE tool was utilized to assess the bias of the included studies. Results: Most studies reported significant outcomes for Mentha oil-treated groups, such as better control of abdominal pain and discomfort, even though two trials did not report superior outcomes. Conclusions: Due to the increasing interest in natural compounds, further clinical trials are necessary to confirm the status of Mentha for improvement in gastrointestinal disorders. Full article
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