Pharmacological Activities and Therapeutic Potential of Novel Drug Derivatives

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".

Deadline for manuscript submissions: 25 June 2025 | Viewed by 351

Special Issue Editors


E-Mail Website
Guest Editor
Department of Organic Chemistry, Faculty of Chemistry, University of Plovdiv “Paisii Hilendarski”, 24, Tzar Asen Str., 4000 Plovdiv, Bulgaria
Interests: synthesis; drug discovery; medicinal chemistry; heterocyclic compounds; organic synthesis; hybrid molecules; nanoparticles; drug delivery systems; drug design
Special Issues, Collections and Topics in MDPI journals

E-Mail
Guest Editor
Department of Medical Physics and Biophysics, Faculty of Pharmacy, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria
Interests: biological activities; isoquinoline alkaloids; immunohistochemical analysis; nitric oxide (NO); smooth muscle contractile activity; synthesis of organic compounds

Special Issue Information

Dear Colleagues,

In modern science, an increasingly rapid dynamic in the development of pharmacology is observed. The main goal is the discovery and design of new drug derivatives with promising therapeutic efficacy which limit the possibility of unwanted side effects. This Special Issue will focus on advances in synthesizing, evaluating, and applying innovative drug derivatives in various therapeutic areas.This Special Issue aims at gathering original research and review articles focused on pharmacological activities of novel compounds, including highly selective anticancer agents and antimicrobial derivatives capable of overcoming resistance mechanisms. Applying a thorough methodology incorporating in silico calculations, in vitro bioassays, and in vivo preclinical evaluations, this Special Issue elucidates the therapeutic advantages and underlying mechanisms of novel derivatives. Contributions that expand the understanding of the potential of these compounds and demonstrate their applications in medicine are encouraged.Research projects examining the potential of medicinal derivatives in the treatment of chronic conditions such as neurodegenerative diseases, autoimmune disorders, and cardiovascular problems are also a focus of interest.We welcome contributions that explore these aspects from both fundamental and applied perspectives, as well as studies aimed at improving the bioavailability, stability, and therapeutic efficacy of contemporary pharmaceuticals. This Special Issue calls for interdisciplinary research addressing regulatory, ethical, and precision medicine challenges to advance therapeutic development.

Dr. Stoyanka Atanasova
Dr. Vera Gledacheva
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • novel drug derivatives
  • synthesis
  • drug design
  • therapeutic potential
  • biological activity
  • pharmacological activity

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

25 pages, 3027 KiB  
Review
Research Progress on Phytochemicals from Mulberry with Neuroprotective Effects: A Review
by Junwei Chen, Zhonglang Gou, Yufei Huang, Qianhui Yu, An Na Kim, Wenchao Shi and You Zhou
Pharmaceuticals 2025, 18(5), 695; https://doi.org/10.3390/ph18050695 - 8 May 2025
Viewed by 77
Abstract
With the intensification of the population aging worldwide, neurological disorders (NDs) are seriously threatening human society. Mulberry, a traditional economic crop, is a significant medicinal plant. Increasing evidence suggests that phytochemicals from mulberry play critical roles in the prevention and treatment of NDs. [...] Read more.
With the intensification of the population aging worldwide, neurological disorders (NDs) are seriously threatening human society. Mulberry, a traditional economic crop, is a significant medicinal plant. Increasing evidence suggests that phytochemicals from mulberry play critical roles in the prevention and treatment of NDs. This paper reviews the recently reported phytochemicals from mulberry with neuroprotective effects and systematically summarizes neuroprotective mechanisms and their classifications. Based on their origins from different parts of mulberry, the extracts with neuroprotective effects are classified into mulberry fruit extract and mulberry leaf extract. According to the compound structures, the compounds are divided into flavonoids, Diels–Alder-type adducts (DAAs), benzofurans, quinones, stilbenes, and alkaloids. This aims to provide a future reference for their pharmaceutical development and utilization. Full article
Show Figures

Figure 1

Back to TopTop