Resveratrol: Pharmacological Mechanisms and Therapeutic Potential as a Natural Product
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Natural Products".
Deadline for manuscript submissions: 20 January 2026 | Viewed by 443
Special Issue Editors
Interests: stilbenes; Micro/Nano polymeric particles; diabetic retinopathy; internalization; tracking and cellular mechanisms
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Resveratrol, a polyphenolic stilbene found in grapes, berries, and Polygonum cuspidatum, continues to engage scholarly interest due to its broad pharmacological profile and therapeutic promise across a range of chronic and degenerative diseases. This Special Issue will consolidate current knowledge on the molecular mechanisms underlying resveratrol’s bioactivity and highlight innovative approaches that could unlock its full clinical potential.
Extensive preclinical evidence supports resveratrol’s modulatory effects on critical signaling pathways, including SIRT1 activation, AMPK signaling, NF-κB inhibition, and oxidative stress reduction. These molecular interactions underpin its antioxidant, anti-inflammatory, neuroprotective, cardioprotective, and anticancer properties. Notably, resveratrol’s ability to influence mitochondrial biogenesis and cellular senescence pathways has renewed interest in its applications in age-related diseases and longevity research. However, despite compelling in vitro data, the compound’s low bioavailability and rapid metabolism pose persistent challenges to clinical translation. As such, there is a growing need to complement in vitro insights with investigations conducted in physiologically relevant in vivo systems, which provide a more comprehensive understanding of resveratrol’s pharmacokinetics, therapeutic efficacy, and safety in a biological context.
By assembling original research articles, mechanistic studies, and translational reviews, this issue will catalyze a shift toward more physiologically relevant models in the study of natural compounds. Resveratrol serves not only as a promising therapeutic candidate but also as a case study of how modern research tools can reshape our understanding of natural compound pharmacology.
Dr. Dumitriţa Rugină
Dr. Roxana Pop
Guest Editors
Manuscript Submission Information
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Keywords
- resveratrol
- natural compound pharmacology
- therapeutic potential
- drug development
- biomedical research
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