Vitamin C: From Bench to Bedside

Dear Colleagues,

Vitamin C (ascorbic acid) is a normal liver metabolite in most animals, with humans being a notable exception due to random genetic mutations that have occurred during our evolution. As such, it has become a vitamin (vital to life), with requirements increasing significantly during various illnesses, particularly severe infections. Recent international clinical trials are highlighting the potential for intravenous vitamin C administration to improve clinical outcomes for patients, particularly those with severe respiratory illness and sepsis, and some cancers. Furthermore, there has been an upsurge in new discoveries and new mechanistic insights, particularly around epigenetic regulation by vitamin C, that are providing rationales for future targeted clinical trials. Other areas with potential benefit from vitamin C include metabolic disorders and mental health. The health benefits from increased vitamin C could be dramatic as the prevalence of these conditions continues to rise. What is needed moving forward are well designed observational and interventional studies, which take into account baseline status and the unique pharmacokinetics of vitamin C, to help address the current gaps in our knowledge. Underpinning mechanistic research will also further our ability to inform good clinical practice.

Assoc. Prof. Anitra Carr
Guest Editor

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