Advances in Sweeteners and Human Health: Metabolic, Molecular, and Epidemiological Perspectives on Safety, Efficacy, and Public Health Impact

Dear Colleagues,

Sweeteners, both natural and artificial, have become prevalent in modern diets due to their ability to satisfy the sweet taste with reduced caloric intake. Their consumption affects multiple facets of human health, including metabolic regulation, gut microbiota composition, cardiovascular outcomes, cancer risk, behavioural responses, and psychological well-being. Despite a wealth of published studies, the evidence remains complex and often contradictory, with opinions sometimes exceeding the robustness of available data.

This Special Issue aims to provide a comprehensive and objective overview that fairly presents current scientific knowledge on sweeteners and human health. We invite rigorous original research articles, systematic reviews, and meta-analyses that critically evaluate the effects of sweeteners, openly acknowledging study limitations and alternative viewpoints. Narrative reviews will be carefully considered to ensure a balanced presentation rather than selective literature support.

By consolidating evidence-based findings and encouraging transparent discourse, we hope to inform clinicians, nutritionists, policymakers, and researchers, facilitating well-informed dietary guidance and regulatory policies on sweetener use. This Special Issue seeks to move beyond polarised debates and offer readers a full, nuanced understanding of the health implications associated with sweetener consumption.

Dr. Ajka Pribisalić
Dr. Davorka Sutlovic
Guest Editors

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