Special Issue "Magnetic Nanoparticles in Biological Applications"
A special issue of Nanomaterials (ISSN 2079-4991).
Deadline for manuscript submissions: closed (31 August 2018).
Interests: polymer self-assemblies; copolymer micelles and vesicles (polymersomes); hybrid polymer/inorganic nanoparticles; polymer drug delivery systems; polymer structures studied by neutron scattering; thermosensitive polymers; polymer grafting
Developed in the 1960s initially for technological applications, stable suspensions of magnetic nanoparticles (MNPs) also called “ferrofluids”, emerged during the 1990s as building blocks for biological applications: Contrast agents for MRI, bio-assays using magnetic separation, internal heat sources for thermo-ablation of tumors, drug carriers with magnetic guiding capability or targeted drug release activated by an applied magnetic field, etc. The research on novel biocompatible MNPs is very active and multidisciplinary, as it involves chemistry for the development of the MNP core and of their coatings, but also physics for the study and optimization of their magnetic properties, pharmacology when dealing with conjugation to biological ligands, drug encapsulation, drug release, etc. From the materials point of view, the chemical composition and crystalline structure of MNP cores can be varied among several transition metals, metal alloys or metal oxides. However, most MNPs aimed to be in contact with living cells or organisms are made of magnetic iron oxides, in order to minimize the risks of toxicity that can arise with other metals (manganese, cobalt, nickel, zinc, etc.). Alternatively, mixed spinels or pristine metals can be used to optimize the magnetic moments. However, they need to be coated with biocompatible shells to avoid ion leashing, either organic or inorganic, as in the development of magnetic core-shells, or even magnetic tri-shells (e.g., ferromagnetic-antiferromagnetic junctions to create exchange bias effects). Other magnetic carriers or magnetic devices are hybrid, i.e., they combine an organic matrix and magnetic nanofillers, creating multi-functional or multimodal probes for bio-imaging. One can cite MNPs combined with liposomes, polymer micelles or vesicles, protein or mesoporous silica shells. In particular, thermosensitive matrixes (polymer chains or gels with a thermal transition, inorganic porous shells filled with wax as gate keepers, etc.) were proposed to tune the drug release kinetics by applied magnetic fields. This Special Issue focuses on all aspects of new nanomaterials using MNPs as active components for biological applications (bio-assays, diagnosis and/or imaging probes, drug delivery systems, etc.), or on the interaction of MNPs with biological media (biological fluids, cell cultures, or living organisms). Studies which shed light on the cellular uptake of MNPs and on the intra-cellular magnetic hyperthermia mechanisms are particularly welcome. Special attention will also be paid to contributions from talented early-stage researchers who are settling their original approaches or new directions in this field of research.
Dr. Olivier Sandre
Manuscript Submission Information
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- bio-compatible magnetic nanoparticles
- MRI contrast agents
- magnetic bio-assays
- magnetic nanoparticle hyperthermia
- magnetically guided drug carriers
- magnetic bio-actuators
- magnetic tumor targeting
- magnetically activated drug release
- magnetic structure and properties
- magnetic metals, alloys and metal oxides
- magnetic core-shells
- magnetic tri-shells
- hybrid magnetic carriers
- magnetic medical devices
- magnetic responsive bio-nanocomposites
- magnetic multi-modal bio-imaging probes
- magnetic thermo-sensitive liposomes
- magnetic polymer micelles or vesicles
- magnetic protein capsules
- magnetic core-mesoporous silica shells
- magnetic thermo-sensitive polymers or gels
- interaction of magnetic nanoparticles with biological media
- magnetic nanoparticle cellular uptake
- intracellular magnetic hyperthermia
- pre-clinical assays on magnetic hyperthermia
- magnetic nanoparticle therapies