Surface Functionalization of Iron Oxide Nanoparticles with Gallic Acid as Potential Antioxidant and Antimicrobial Agents
AbstractIn this research, we report the size-controlled synthesis and surface-functionalization of magnetite with the natural antioxidant gallic acid (GA) as a ligand, using in situ and post-synthesis methods. GA functionalization provided narrow size distribution, with an average particle size of 5 and 8 nm for in situ synthesis of gallic acid functionalized magnetite [email protected] and [email protected], respectively, which are ultra-small particles as compared to unfunctionalized magnetite (IONP) and post functionalized magnetite [email protected] with average size of 10 and 11 nm respectively. All the [email protected] samples were found hydrophilic with stable aggregation state. Prior to commencement of experimental lab work, PASS software was used to predict the biological activities of GA and it is found that experimental antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and antimicrobial studies using well diffusion method are in good agreement with the simulated results. Furthermore, the half maximal inhibitory concentration (IC50) values of DPPH antioxidant assay revealed a 2–4 fold decrease as compared to unfunctionalized IONP. In addition to antioxidant activity, all the three [email protected] proved outstanding antimicrobial activity while testing on different bacterial and fungal strains. The results collectively indicate the successful fabrication of novel antioxidant, antimicrobial [email protected] composite, which are magnetically separable, efficient, and low cost, with potential applications in polymers, cosmetics, and biomedical and food industries. View Full-Text
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Shah, S.T.; A Yehya, W.; Saad, O.; Simarani, K.; Chowdhury, Z.; A. Alhadi, A.; Al-Ani, L.A. Surface Functionalization of Iron Oxide Nanoparticles with Gallic Acid as Potential Antioxidant and Antimicrobial Agents. Nanomaterials 2017, 7, 306.
Shah ST, A Yehya W, Saad O, Simarani K, Chowdhury Z, A. Alhadi A, Al-Ani LA. Surface Functionalization of Iron Oxide Nanoparticles with Gallic Acid as Potential Antioxidant and Antimicrobial Agents. Nanomaterials. 2017; 7(10):306.Chicago/Turabian Style
Shah, Syed Tawab; A Yehya, Wageeh; Saad, Omer; Simarani, Khanom; Chowdhury, Zaira; A. Alhadi, Abeer; Al-Ani, Lina A. 2017. "Surface Functionalization of Iron Oxide Nanoparticles with Gallic Acid as Potential Antioxidant and Antimicrobial Agents." Nanomaterials 7, no. 10: 306.
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