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Magnetofluorescent Nanocomposite Comprised of Carboxymethyl Dextran Coated Superparamagnetic Iron Oxide Nanoparticles and β-Diketon Coordinated Europium Complexes

1
Department of Cell Biology, Konyang University College of Medicine, Daejeon 302-718, Korea
2
Department of Anatomy, College of Medicine, Konyang University, Daejeon 302-718, Korea
3
Myunggok Medical Research Institute, Konyang University College of Medicine, Daejeon 302-718, Korea
*
Authors to whom correspondence should be addressed.
Nanomaterials 2019, 9(1), 62; https://doi.org/10.3390/nano9010062
Received: 10 December 2018 / Revised: 27 December 2018 / Accepted: 29 December 2018 / Published: 4 January 2019
(This article belongs to the Special Issue Magnetic Nanoparticles in Biological Applications)
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Abstract

Red emitting europium (III) complexes Eu(TFAAN)3(P(Oct)3)3 (TFAAN = 2-(4,4,4-Trifluoroacetoacetyl)naphthalene, P(Oct)3 = trioctylphosphine) chelated on carboxymethyl dextran coated superparamagnetic iron oxide nanoparticles (CMD-SPIONs) was synthesized and the step wise synthetic process was reported. All the excitation spectra of distinctive photoluminesces were originated from f-f transition of EuIII with a strong red emission. The emission peaks are due to the hypersensitive transition 5D07F2 at 621 nm and 5D07F1 at 597 nm, 5D07F0 at 584 nm. No significant change in PL properties due to addition of CMD-SPIONs was observed. The cytotoxic effects of different concentrations and incubation times of Eu(TFAAN)3(P(Oct)3)3 chelated CMD-SPIONs were evaluated in HEK293T and HepG2 cells using the WST assay. The results imply that Eu(TFAAN)3(P(Oct)3)3 chelated CMD-SPIONs are not affecting the cell viability without altering the apoptosis and necrosis in the range of 10 to 240 μg/mL concentrations. View Full-Text
Keywords: europium complexes; superparamagnetic; iron oxide nanoparticles; magnetofluorescent europium complexes; superparamagnetic; iron oxide nanoparticles; magnetofluorescent
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Han, D.; Han, S.-Y.; Lee, N.S.; Shin, J.; Jeong, Y.G.; Park, H.-W.; Kim, D.K. Magnetofluorescent Nanocomposite Comprised of Carboxymethyl Dextran Coated Superparamagnetic Iron Oxide Nanoparticles and β-Diketon Coordinated Europium Complexes. Nanomaterials 2019, 9, 62.

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