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Open AccessArticle

Optimization of Iron Oxide Tracer Synthesis for Magnetic Particle Imaging

1
MR and CT Contrast Media Research, Bayer AG, D-13353 Berlin, Germany
2
Physikalisch-Technische Bundesanstalt, D-10587 Berlin, Germany
3
University of British Columbia, Vancouver, BC V6T 1Z3, Canada
*
Author to whom correspondence should be addressed.
Nanomaterials 2018, 8(4), 180; https://doi.org/10.3390/nano8040180
Received: 23 February 2018 / Revised: 17 March 2018 / Accepted: 19 March 2018 / Published: 21 March 2018
(This article belongs to the Special Issue Magnetic Nanoparticles in Biological Applications)
The optimization of iron oxide nanoparticles as tracers for magnetic particle imaging (MPI) alongside the development of data acquisition equipment and image reconstruction techniques is crucial for the required improvements in image resolution and sensitivity of MPI scanners. We present a large-scale water-based synthesis of multicore superparamagnetic iron oxide nanoparticles stabilized with dextran (MC-SPIONs). We also demonstrate the preparation of single core superparamagnetic iron oxide nanoparticles in organic media, subsequently coated with a poly(ethylene glycol) gallic acid polymer and phase transferred to water (SC-SPIONs). Our aim was to obtain long-term stable particles in aqueous media with high MPI performance. We found that the amplitude of the third harmonic measured by magnetic particle spectroscopy (MPS) at 10 mT is 2.3- and 5.8-fold higher than Resovist for the MC-SPIONs and SC-SPIONs, respectively, revealing excellent MPI potential as compared to other reported MPI tracer particle preparations. We show that the reconstructed MPI images of phantoms using optimized multicore and specifically single-core particles are superior to that of commercially available Resovist, which we utilize as a reference standard, as predicted by MPS. View Full-Text
Keywords: magnetic particle imaging (MPI); magnetic particle spectroscopy (MPS); iron oxide tracer; superparamagnetic nanoparticles magnetic particle imaging (MPI); magnetic particle spectroscopy (MPS); iron oxide tracer; superparamagnetic nanoparticles
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Ziemian, S.; Löwa, N.; Kosch, O.; Bajj, D.; Wiekhorst, F.; Schütz, G. Optimization of Iron Oxide Tracer Synthesis for Magnetic Particle Imaging. Nanomaterials 2018, 8, 180.

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