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Nanomaterials 2018, 8(4), 196; https://doi.org/10.3390/nano8040196

Can Pulsed Electromagnetic Fields Trigger On-Demand Drug Release from High-Tm Magnetoliposomes?

1
Department of Drug Chemistry and Technologies, “Sapienza” University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
2
Department of Information Engineering, Electronics and Telecommunications (DIET), “Sapienza” University of Rome, Via Eudossiana 18, 00184 Rome, Italy
3
Department of Anatomical, Histological, Forensic Medicine and Orthopedic Science, “Sapienza” University of Rome, Via A. Borelli 50, 00161 Rome, Italy
*
Author to whom correspondence should be addressed.
Received: 19 February 2018 / Revised: 22 March 2018 / Accepted: 23 March 2018 / Published: 27 March 2018
(This article belongs to the Special Issue Magnetic Nanoparticles in Biological Applications)
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Abstract

Recently, magnetic nanoparticles (MNPs) have been used to trigger drug release from magnetoliposomes through a magneto-nanomechanical approach, where the mechanical actuation of the MNPs is used to enhance the membrane permeability. This result can be effectively achieved with low intensity non-thermal alternating magnetic field (AMF), which, however, found rare clinic application. Therefore, a different modality of generating non-thermal magnetic fields has now been investigated. Specifically, the ability of the intermittent signals generated by non-thermal pulsed electromagnetic fields (PEMFS) were used to verify if, once applied to high-transition temperature magnetoliposomes (high-Tm MLs), they could be able to efficiently trigger the release of a hydrophilic model drug. To this end, hydrophilic MNPs were combined with hydrogenated soybean phosphatidylcholine and cholesterol to design high-Tm MLs. The release of a dye was evaluated under the effect of PEMFs for different times. The MNPs motions produced by PEMF could effectively increase the bilayer permeability, without affecting the liposomes integrity and resulted in nearly 20% of release after 3 h exposure. Therefore, the current contribution provides an exciting proof-of-concept for the ability of PEMFS to trigger drug release, considering that PEMFS find already application in therapy due to their anti-inflammatory effects. View Full-Text
Keywords: magneto mechanical trigger; magnetoliposomes; on-demand drug release; magneto nanoparticles; PEMF; non-thermal magnetic field magneto mechanical trigger; magnetoliposomes; on-demand drug release; magneto nanoparticles; PEMF; non-thermal magnetic field
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Nardoni, M.; Della Valle, E.; Liberti, M.; Relucenti, M.; Casadei, M.A.; Paolicelli, P.; Apollonio, F.; Petralito, S. Can Pulsed Electromagnetic Fields Trigger On-Demand Drug Release from High-Tm Magnetoliposomes? Nanomaterials 2018, 8, 196.

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