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Nanomaterials 2018, 8(10), 850; https://doi.org/10.3390/nano8100850

Magnetic Nanoparticles Create Hot Spots in Polymer Matrix for Controlled Drug Release

1
Sorbonne Université, CNRS, PHysico-Chimie des Electrolytes et Nanosystèmes InterfaciauX, PHENIX, F-75005 Paris, France
2
Laboratoire Matière et Systèmes Complexes (MSC), UMR 7057, CNRS and Université Paris Diderot, 75205 Paris CEDEX 05, France
*
Authors to whom correspondence should be addressed.
Received: 20 August 2018 / Revised: 9 October 2018 / Accepted: 11 October 2018 / Published: 18 October 2018
(This article belongs to the Special Issue Magnetic Nanoparticles in Biological Applications)
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Abstract

Herein, original magnetic drug delivery nanomaterials for cancer therapy are developed and compared, with the purpose to show active control over drug release by using an alternative magnetic field (AMF). The rationale is to combine polymers and superparamagnetic nanoparticles to trigger such drug release under AMF. Two magnetic nanosystems are thus presented: magnetic nanogels made of thermosensitive and biocompatible polymers and core-shell nanoparticles with a magnetic core and a molecularly imprinted polymer as shell. Both encapsulate doxorubicin (DOX) and the DOX controlled release was investigated in vitro and in cells under AMF excitation. It confirms that the local heat profile at the vicinity of the iron oxide core can be used for the DOX controlled release. It also shows that both nanosystems help delivering more DOX inside the cells compared to internalization of free DOX. Finally, the DOX intracellular release could be remotely triggered under AMF, in athermal conditions, thus enhancing DOX cytotoxicity. View Full-Text
Keywords: magnetic nanoparticles; alternative magnetic field; thermosensitive polymer; molecularly imprinted polymer; drug release magnetic nanoparticles; alternative magnetic field; thermosensitive polymer; molecularly imprinted polymer; drug release
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Cazares-Cortes, E.; Nerantzaki, M.; Fresnais, J.; Wilhelm, C.; Griffete, N.; Ménager, C. Magnetic Nanoparticles Create Hot Spots in Polymer Matrix for Controlled Drug Release. Nanomaterials 2018, 8, 850.

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