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Nanomaterials 2018, 8(1), 3; https://doi.org/10.3390/nano8010003

A Novel Magnetic Actuation Scheme to Disaggregate Nanoparticles and Enhance Passage across the Blood–Brain Barrier

1
Faculty of Industrial and Mechanical Engineering, Islamic Azad University, Qazvin Branch, Qazvin 34199-15195, Iran
2
School of Integrated Technology, Gwangju Institute of Science and Technology, 123 Cheomdangwagi-ro, Buk-gu, Gwangju 61005, Korea
3
Department of Biology and Applied Life Science, Gyeongsang National University, Jinju 660-701, Korea
*
Author to whom correspondence should be addressed.
Received: 16 November 2017 / Revised: 14 December 2017 / Accepted: 16 December 2017 / Published: 22 December 2017
(This article belongs to the Special Issue Magnetic Nanoparticles in Biological Applications)
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Abstract

The blood–brain barrier (BBB) hinders drug delivery to the brain. Despite various efforts to develop preprogramed actuation schemes for magnetic drug delivery, the unmodeled aggregation phenomenon limits drug delivery performance. This paper proposes a novel scheme with an aggregation model for a feed-forward magnetic actuation design. A simulation platform for aggregated particle delivery is developed and an actuation scheme is proposed to deliver aggregated magnetic nanoparticles (MNPs) using a discontinuous asymmetrical magnetic actuation. The experimental results with a Y-shaped channel indicated the success of the proposed scheme in steering and disaggregation. The delivery performance of the developed scheme was examined using a realistic, three-dimensional (3D) vessel simulation. Furthermore, the proposed scheme enhanced the transport and uptake of MNPs across the BBB in mice. The scheme presented here facilitates the passage of particles across the BBB to the brain using an electromagnetic actuation scheme. View Full-Text
Keywords: asymmetrical discontinuous field function; blood–brain barrier (BBB); magnetic drug delivery; magnetic nanoparticles; aggregation asymmetrical discontinuous field function; blood–brain barrier (BBB); magnetic drug delivery; magnetic nanoparticles; aggregation
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Hoshiar, A.K.; Le, T.-A.; Amin, F.U.; Kim, M.O.; Yoon, J. A Novel Magnetic Actuation Scheme to Disaggregate Nanoparticles and Enhance Passage across the Blood–Brain Barrier. Nanomaterials 2018, 8, 3.

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