Next Article in Journal
Protective Properties of a Microstructure Composed of Barrier Nanostructured Organics and SiOx Layers Deposited on a Polymer Matrix
Next Article in Special Issue
Magnetic Targeting of Growth Factors Using Iron Oxide Nanoparticles
Previous Article in Journal
Charge Transport in Trap-Sensitized Infrared PbS Quantum-Dot-Based Photoconductors: Pros and Cons
Previous Article in Special Issue
Kinetics of Aggregation and Magnetic Separation of Multicore Iron Oxide Nanoparticles: Effect of the Grafted Layer Thickness
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessArticle

Development of Magnetically Active Scaffolds for Bone Regeneration

1
Escuela de Ingeniería de Bilbao, Departamento de Ingeniería Minera, Metalúrgica y Ciencia de Materiales, Universidad del País Vasco (UPV/EHU), 48920 Portugalete, Spain
2
BCMaterials, Basque Centre for Materials, Applications and Nanostructures, UPV/EHU Science Park, 48940 Leioa, Spain
3
Facultad de Ciencia y Tecnología, Departamento de Electricidad y Electrónica, University of the Basque Country (UPV/EHU), Sarriena s/n, 48940 Leioa, Spain
4
Centro/Departamento de Física, Universidade do Minho, 4710-057 Braga, Portugal
5
Centre of Molecular and Environmental Biology (CBMA), Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal
6
IKERBASQUE, Basque Foundation for Science, 48013 Bilbao, Spain
*
Author to whom correspondence should be addressed.
Nanomaterials 2018, 8(9), 678; https://doi.org/10.3390/nano8090678
Received: 1 August 2018 / Revised: 27 August 2018 / Accepted: 28 August 2018 / Published: 30 August 2018
(This article belongs to the Special Issue Magnetic Nanoparticles in Biological Applications)
  |  
PDF [3676 KB, uploaded 31 August 2018]
  |  

Abstract

This work reports on the synthesis, with the thermally induced phase separation (TIPS) technique, of poly (l-lactide) (PLLA) scaffolds containing Fe-doped hydroxyapatite (FeHA) particles for bone regeneration. Magnetization curves and X-ray diffraction indicate two magnetic particle phases: FeHA and magnetite Fe3O4. Magnetic nanoparticles (MNPs) are approximately 30 ± 5 nm in width and 125 ± 25 nm in length, and show typical ferromagnetic properties, including coercivity and rapid saturation magnetization. Scanning electron microscopy (SEM) images of the magnetic scaffolds reveal their complex morphology changes with MNP concentration. Similarly, at compositions of approximately 20% MNPs, the phase separation changes, passing from solid–liquid to liquid–liquid as revealed by the hill-like structures, with low peaks that give the walls in the SEM images a surface pattern of micro-ruggedness typical of nucleation mechanisms and growth. In vitro degradation experiments, carried out for more than 28 weeks, demonstrated that the MNPs delay the scaffold degradation process. Cytotoxicity is appreciated for FeHA content above 20%. View Full-Text
Keywords: Fe-doped hydroxyapatite; poly (l-lactide); scaffolds; magnetism; cytotoxicity Fe-doped hydroxyapatite; poly (l-lactide); scaffolds; magnetism; cytotoxicity
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Díaz, E.; Valle, M.B.; Ribeiro, S.; Lanceros-Mendez, S.; Barandiarán, J.M. Development of Magnetically Active Scaffolds for Bone Regeneration. Nanomaterials 2018, 8, 678.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nanomaterials EISSN 2079-4991 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top