Development of a Sensitive Induction-Based Magnetic Nanoparticle Biodetection Method
AbstractWe developed a novel biodetection method for influenza virus based on AC magnetic susceptibility measurement techniques (the DynoMag induction technique) together with functionalized multi-core magnetic nanoparticles. The sample consisting of an incubated mixture of magnetic nanoparticles and rolling circle amplified DNA coils is injected into a tube by a peristaltic pump. The sample is moved as a plug to the two well-balanced detection coils and the dynamic magnetic moment in each position is read over a range of excitation frequencies. The time for making a complete frequency sweep over the relaxation peak is about 5 minutes (10 Hz–10 kHz with 20 data points). The obtained standard deviation of the magnetic signal at the relaxation frequency (around 100 Hz) is equal to about 10−5 (volume susceptibility SI units), which is in the same range obtained with the DynoMag system. The limit of detection with this method is found to be in the range of 1 pM. View Full-Text
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Blomgren, J.; Ahrentorp, F.; Ilver, D.; Jonasson, C.; Sepehri, S.; Kalaboukhov, A.; Winkler, D.; Zardán Gómez de la Torre, T.; Strømme, M.; Johansson, C. Development of a Sensitive Induction-Based Magnetic Nanoparticle Biodetection Method. Nanomaterials 2018, 8, 887.
Blomgren J, Ahrentorp F, Ilver D, Jonasson C, Sepehri S, Kalaboukhov A, Winkler D, Zardán Gómez de la Torre T, Strømme M, Johansson C. Development of a Sensitive Induction-Based Magnetic Nanoparticle Biodetection Method. Nanomaterials. 2018; 8(11):887.Chicago/Turabian Style
Blomgren, Jakob; Ahrentorp, Fredrik; Ilver, Dag; Jonasson, Christian; Sepehri, Sobhan; Kalaboukhov, Alexei; Winkler, Dag; Zardán Gómez de la Torre, Teresa; Strømme, Maria; Johansson, Christer. 2018. "Development of a Sensitive Induction-Based Magnetic Nanoparticle Biodetection Method." Nanomaterials 8, no. 11: 887.
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