Next Article in Journal
Poly(vinylidene fluoride) and Carbon Derivative Structures from Eco-Friendly MOF-5 for Supercapacitor Electrode Preparation with Improved Electrochemical Performance
Next Article in Special Issue
Magnetic Polyion Complex Micelles for Cell Toxicity Induced by Radiofrequency Magnetic Field Hyperthermia
Previous Article in Journal
Synthesis of Reduced Graphene Oxide with Adjustable Microstructure Using Regioselective Reduction in the Melt of Boric Acid: Relationship Between Structural Properties and Electrochemical Performance
Previous Article in Special Issue
Unravelling the Thermal Decomposition Parameters for The Synthesis of Anisotropic Iron Oxide Nanoparticles
Article Menu
Issue 11 (November) cover image

Export Article

Open AccessArticle

Development of a Sensitive Induction-Based Magnetic Nanoparticle Biodetection Method

1
RISE Acreo, SE-411 33 Göteborg, Sweden
2
Department of Microtechnology and Nanoscience–MC2, Chalmers University of Technology, SE-412 96 Göteborg, Sweden
3
Department of Engineering Sciences, Uppsala University, The Ångström Laboratory, SE-751 21 Uppsala, Sweden
*
Author to whom correspondence should be addressed.
Nanomaterials 2018, 8(11), 887; https://doi.org/10.3390/nano8110887
Received: 2 October 2018 / Revised: 25 October 2018 / Accepted: 26 October 2018 / Published: 1 November 2018
(This article belongs to the Special Issue Magnetic Nanoparticles in Biological Applications)
  |  
PDF [1871 KB, uploaded 1 November 2018]
  |  

Abstract

We developed a novel biodetection method for influenza virus based on AC magnetic susceptibility measurement techniques (the DynoMag induction technique) together with functionalized multi-core magnetic nanoparticles. The sample consisting of an incubated mixture of magnetic nanoparticles and rolling circle amplified DNA coils is injected into a tube by a peristaltic pump. The sample is moved as a plug to the two well-balanced detection coils and the dynamic magnetic moment in each position is read over a range of excitation frequencies. The time for making a complete frequency sweep over the relaxation peak is about 5 minutes (10 Hz–10 kHz with 20 data points). The obtained standard deviation of the magnetic signal at the relaxation frequency (around 100 Hz) is equal to about 10−5 (volume susceptibility SI units), which is in the same range obtained with the DynoMag system. The limit of detection with this method is found to be in the range of 1 pM. View Full-Text
Keywords: magnetic nanoparticles; magnetic biosensing; Brownian relaxation; AC susceptibility; multi-core particles magnetic nanoparticles; magnetic biosensing; Brownian relaxation; AC susceptibility; multi-core particles
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Blomgren, J.; Ahrentorp, F.; Ilver, D.; Jonasson, C.; Sepehri, S.; Kalaboukhov, A.; Winkler, D.; Zardán Gómez de la Torre, T.; Strømme, M.; Johansson, C. Development of a Sensitive Induction-Based Magnetic Nanoparticle Biodetection Method. Nanomaterials 2018, 8, 887.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nanomaterials EISSN 2079-4991 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top