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Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Bioenergetics in Diet and Metabolism: Nutritional Pathways to Health

edited by

Cennet Yıldız

and

Xinhui Wang

submission deadline 31 Jan 2026 | Viewed by 286 | Submission Open

Keywords: bioenergetics; metabolic efficiency; energy metabolism; nutritional interventions; diet-induced thermogenesis; macronutrient composition; metabolic health; metabolic disorders; biothermodynamics; entropy

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolic Crosstalk in the Tumor Microenvironment

edited by

Drenka Trivanovic

Ristic Biljana

and

Vesna M. Ćorić

submission deadline 31 Jan 2026 | Viewed by 213 | Submission Open

Keywords: cancer; oncometabolites; tumor microenvironment; metabolic crosstalk

(This special issue belongs to the Section Cell Metabolism)

Bioactive Metabolites from Fungal Endophytes Associated with Medicinal Plants

edited by

Zhong-Hua Tang

and Chun-Hao Chang

submission deadline 31 Jan 2026 | Viewed by 205 | Submission Open

Keywords: medicinal plants; fungal endophytes; bioactive metabolites; symbiotic interaction; biosynthetic gene clusters; plant– microbe co-evolution; natural product discovery; metabolomics; synthetic biology; antimicrobial activity

(This special issue belongs to the Section Plant Metabolism)

Hypoxia and Its Role in Cellular Metabolism: Mechanisms and Implications

edited by

Raja Gopal Reddy Mooli

Hang Cheng

and

Nathan Lanning

submission deadline 31 Jan 2026 | Viewed by 185 | Submission Open

Keywords: oxygen; hypoxia; metabolism; Hypoxia Inducible Factors (HIFs); prolyl hydroxylase domain-containing enzymes (PHDs); metabolic regulation; glucose metabolism; fatty acid metabolism; TCA cycle; metabolites

(This special issue belongs to the Section Cell Metabolism)

Nutritional Interventions and Lipid Metabolism

edited by

Cecilia Bender

and

Mariano Stornaiuolo

submission deadline 31 Jan 2026 | Viewed by 161 | Submission Open

Keywords: lipid metabolism; nutritional interventions; dietary fats; bioactive compounds; functional foods; chronic diseases; nutrigenomics; weight management; inflammation; personalized nutrition

(This special issue belongs to the Section Lipid Metabolism)

Zebrafish Models in the Study of Diabetes and Metabolic Dysfunction

edited by Liqing Zang

submission deadline 31 Jan 2026 | Viewed by 161 | Submission Open

Keywords: zebrafish; diabetes; obesity; metabolic dysfunction; insulin resistance; hyperglycemia; lipid metabolism; drug screening; nutraceuticals; gene editing; high-fat diet; metabolomics

(This special issue belongs to the Section Animal Metabolism)

Metabolomic Strategies for Deep Systems Profiling Towards Biomarker Discovery and Precision Medicine

edited by

Silvia Valentinuzzi

and

Troy D. Wood

submission deadline 31 Jan 2026 | Viewed by 147 | Submission Open

Keywords: metabolomics; biomarker discovery; mass spectrometry; omics integration; molecular signatures; precision medicine

(This special issue belongs to the Section Integrative Metabolomics)

Metabolic Changes During Pre- and Post-Harvest Fruit and Vegetable Decay, Ripening and Senescence—2nd Edition

edited by

Analía Concellón

and

María José Zaro

submission deadline 2 Feb 2026 | 1 articles | Viewed by 1157 | Submission Open

Keywords: pre- and post-harvest technology; bio-stimulants and abiotic stress; nutritional quality; metabolic pathway; bioactive compounds; chilling injury

(This special issue belongs to the Section Plant Metabolism)

Nutritional Metabolism and Metabolome in Plants

edited by

Chuanying Fang

and Kang Li

submission deadline 10 Feb 2026 | Viewed by 273 | Submission Open

Keywords: nutritional metabolism; metabolomic; plant growth; development; and stress responses; metabolism-environmental factor interactions; genetic and molecular mechanisms; applications of plant metabolites

(This special issue belongs to the Section Plant Metabolism)

Vitamin D Metabolism and Human Health

edited by

Magdalena Kowalówka

Marta Karaźniewicz-Łada

and

Ilona Górna

submission deadline 12 Feb 2026 | 2 articles | Viewed by 9252 | Submission Open

Keywords: vitamin D; metabolites vitamin D; metabolic pathways; metabolic perturbations; vitamin D receptor; enzymes; polymorphism; vitamin D deficiency; health; metabolic diseases; nutrition

(This special issue belongs to the Section Nutrition and Metabolism)

NMR-Based Metabolomics in Biomedicine and Food Science

edited by

Gaia Meoni

and

Alessia Vignoli

submission deadline 13 Feb 2026 | 3 articles | Viewed by 3106 | Submission Open

Keywords: metabolomics; NMR; biomedicine; food; fingerprinting; profiling; AI; ML

(This special issue belongs to the Section Metabolomic Profiling Technology)

Metabolism in Kidney Disease

edited by

Vincenzo Calabrese

Elisa Longhitano

and

Domenico Santoro

submission deadline 15 Feb 2026 | 2 articles | Viewed by 2289 | Submission Open

Keywords: biomarkers; CKD; dialysis; electrolytes; metabolism; inflammation; survey

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Effects of Nutrition and Exercise on Cardiometabolic Health

edited by

Sam Emerson

submission deadline 16 Feb 2026 | 2 articles | Viewed by 2394 | Submission Open

Keywords: cardiovascular health; metabolic health; diet; nutrition; exercise; physical activity; body composition; obesity; metabolites; metabolism

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Role of Lipid Metabolism in Cardiovascular Health

edited by Irma Magaly Rivas Serna and

Timothy O'Toole

submission deadline 16 Feb 2026 | 1 articles | Viewed by 1043 | Submission Open

Keywords: metabolism of lipids; lipid classes; lipid species; cardiovascular health; lipidomics; cardiometabolic disease; cardiovascular disease; atherosclerosis; dyslipidemia; phospholipids; glyceride lipids; non-glyceride lipids; sphingolipids; ceramides; cardiac biomarkers; mechanism

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomic Insights: Interplay Between Metabolism and Immune Response in Cancer

edited by

Dimitra Rafailia Bakaloudi

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1236 | Submission Open

Keywords: metabolites; metabolism; cancer; immune response; immunotherapy; immunometabolism

(This special issue belongs to the Section Cell Metabolism)

Secondary Metabolites and Their Activities: From the Identification to the Biological Investigation

edited by Valeria Cavalloro and

Emanuela Martino

submission deadline 28 Feb 2026 | 5 articles | Viewed by 13932 | Submission Open

Keywords: active metabolites; green extraction; bioactivity; natural products; structural elucidation

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Emerging Applications of Metabolomics in Fermented Food

edited by

Eiichiro Fukusaki

, Akira Oikawa,

Yasuyo Sekiyama

and Kazuhiro Iwashita

submission deadline 28 Feb 2026 | 4 articles | Viewed by 9766 | Submission Open

Keywords: food metabolomics; fermented food; fermentation; fermentation microorganisms; flavor; food secondary function; sensory evaluation; health-promoting function; food ternary function; nutrition

(This special issue belongs to the Section Food Metabolomics)

Insights into the Metabolic Absorption of Bioactive Peptides Derived from Food Sources

edited by

Boqun Liu

submission deadline 28 Feb 2026 | 3 articles | Viewed by 8356 | Submission Open

Keywords: peptide; absorption; metabolism; structure– function relationships; metabolic pathways

(This special issue belongs to the Section Nutrition and Metabolism)

Advances in Food Metabolomics for Functional Food Development and Analysis

edited by

Amanda J. Lloyd

and

MJ Pilar Martinez-Martin

submission deadline 28 Feb 2026 | 5 articles | Viewed by 6702 | Submission Open

Keywords: natural food fortification; functional foods; bioactive compounds; nutraceuticals; food biofortification; food analysis; nutritional enhancement; food testing; metabolomics

(This special issue belongs to the Section Food Metabolomics)

Novel Approaches for Metabolomics in Drugs and Biomarkers Discovery: 2nd Edition

edited by

Cecília R.C. Calado

submission deadline 28 Feb 2026 | 4 articles | Viewed by 5937 | Submission Open

Keywords: metabolomics; drugs discovery; biomarkers discovery; diagnostic; prognosis

(This special issue belongs to the Section Advances in Metabolomics)

Phytochemicals and Pharmacological Significance of Plant Secondary Metabolites in Medicine

edited by

Katarzyna Jakimiuk

and Arkadiusz Surażyński

submission deadline 28 Feb 2026 | 3 articles | Viewed by 5449 | Submission Open

Keywords: natural plant products; biological and pharmacological activity; isolation; disease prevention and treatment; natural plant drug discovery

(This special issue belongs to the Section Plant Metabolism)

Bioactive Metabolites from Plants

edited by

Luis Francisco Salomé-Abarca

and

Dejan Godjevac

submission deadline 28 Feb 2026 | 4 articles | Viewed by 4850 | Submission Open

Keywords: metabolites; bioactivity; identification; quantification; metabolomics; nutraceuticals; antibiosis; antixenosis; medicinal

(This special issue belongs to the Section Plant Metabolism)

Advances in Metabolomics for Precision Medicine: From Biomarker Discovery to Clinical Applications

edited by Adam D. Kennedy and Greg Michelotti

submission deadline 28 Feb 2026 | 4 articles | Viewed by 4453 | Submission Open

Keywords: metabolomics; precision medicine; clinical disease; biomarkers; therapeutics; clinical metabolomics; nutrition; functional medicine

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomics Studies in Ruminant Models: Unraveling Nutritional Physiology and Health

edited by

Jože Starič

and

Marko R. Cincovic

submission deadline 28 Feb 2026 | 3 articles | Viewed by 4387 | Submission Open

Keywords: feed supplements; metabolic profiles; metabolic biomarkers; metabolic stress; metabolomics

(This special issue belongs to the Section Advances in Metabolomics)

Lipid Biomarkers and Cardiometabolic Diseases—2nd Edition

edited by

Hyun Suk Yang

submission deadline 28 Feb 2026 | 3 articles | Viewed by 4346 | Submission Open

Keywords: lipid profiles; lipid metabolism; cholesterol; dietary fat; cardiovascular diseases; metabolic diseases

(This special issue belongs to the Section Lipid Metabolism)

Advances in Murine Models for Metabolic Diseases: Insights into Diabetes, Obesity, and Cardiovascular Conditions

edited by

Samuel Treviño

submission deadline 28 Feb 2026 | 3 articles | Viewed by 3865 | Submission Open

Keywords: murine models; metabolic diseases; molecular mechanisms; biochemical pathways; pharmacological strategies; interactome; comorbidities; metabolic phenotypes; novel techniques

(This special issue belongs to the Section Nutrition and Metabolism)

Effects of Stress on Animal Metabolism

edited by

Krystyna Pierzchala-Koziec

and Colin Scanes

submission deadline 28 Feb 2026 | 4 articles | Viewed by 3425 | Submission Open

Keywords: stressors; ACTH; glucocorticoids; mineralocorticoids; opioids; glycemia; growth; development; lactation; pregnancy

(This special issue belongs to the Section Animal Metabolism)

New Trends in Drug Pharmacokinetics and Metabolism Research

edited by

Rongjin Sun

and Steven C. Laizure

submission deadline 28 Feb 2026 | Viewed by 3019 | Submission Open

Keywords: local bioavailable drug; drug– herb interactions; machine learning; advanced modeling techniques; gut microbiome; in vitro to in vivo extrapolation; monoclonal antibodies; peptides; oligonucleotides

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Bioactive Plant Extracts: Phytochemical Characterization, Isolation and Biological Evaluation

edited by

Sergio Ortiz

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1921 | Submission Open

Keywords: extraction; metabolomics; phytochemical dereplication; isolation of plant metabolites; biological evaluation

(This special issue belongs to the Section Plant Metabolism)

Synthetic Biology Approaches for Expanding the Metabolic Capabilities of E. coli

edited by

Angelo Bañares

and Kei Anne Baritugo

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1577 | Submission Open

Keywords: synthetic biology; Escherichia coli (E. coli); metabolic engineering; genome editing (crispr-cas9); novel metabolic pathways; high-value chemicals; biofuels; bioremediation; environmental sensing; microbial cell factory

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Metabolomics in Food Science and Nutrition Using GC-MS

edited by

Ryota Mabuchi

Genya Okada

and

Yonghuan Yun

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1322 | Submission Open

Keywords: GC-MS; metabolome analysis; metabolic profiling; foodomics; nutritional metabolomics; dietary bi-omarkers; food quality; primary metabolites; lipidomics; odor and/or aroma components

(This special issue belongs to the Section Food Metabolomics)

Integration of Proteomics and Metabolomics: A Comprehensive Approach to Omics Research

edited by

Marcel Kwiatkowski

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1086 | Submission Open

Keywords: metabolomics; proteomics; metabolic flux analysis; PTMs; cross-omics; data integration; systems biology; computational modelling

(This special issue belongs to the Section Advances in Metabolomics)

Nutrition and Metabolic Changes in Aging and Age-Related Diseases: 2nd Edition

edited by Qi Zhang

submission deadline 28 Feb 2026 | 1 articles | Viewed by 763 | Submission Open

Keywords: senescence; metabolism; nutrient homeostasis; aging; SASP (senescence-associated secretory phenotype)

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolomics in Human Diseases and Health: 2nd Edition

edited by

Dimitris Kounatidis

and

Iordanis Mourouzis

submission deadline 28 Feb 2026 | 2 articles | Viewed by 621 | Submission Open

Keywords: metabolomics; NAFLD; biomarkers; obesity; mass spectrometry; NMR spectroscopy; diabetes mellitus; cancer; cardiovascular diseases; neurodegenerative diseases

(This special issue belongs to the Section Advances in Metabolomics)

Drug Metabolism, Interactions and Toxicity: Advances in Metabolomics Approaches

edited by

Pengcheng Wang

and Rheem A. Totah

submission deadline 28 Feb 2026 | 1 articles | Viewed by 498 | Submission Open

Keywords: metabolomics; drug/xenobiotic metabolism; drug– drug interactions; drug– endobiotic interactions; drug toxicity; biomarkers; ADME; 3D in vitro model

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Metabolomic Technology in Quality and Safety of Agricultural Products and Foods, 2nd Edition

edited by

Yasuhiro Date

submission deadline 28 Feb 2026 | 1 articles | Viewed by 443 | Submission Open

Keywords: metabolomics; metabolic profiling; metabolic fingerprinting; foodomics; nuclear magnetic resonance spectroscopy; mass spectrometry; multivariate analysis; machine learning

(This special issue belongs to the Section Food Metabolomics)

Insulin Clearance and Metabolic Dysregulation in Health and Disease

edited by

Morvarid Kabir

and Richard N. Bergman

submission deadline 28 Feb 2026 | Viewed by 372 | Submission Open

Keywords: insulin clearance; insulin resistance; type 2 diabetes; obesity; hyperinsulinemia; metabolic dysfunction

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Toxicometabolomics for Metabotyping and Novel Mechanisms

edited by

Chi Chen

and

Qingqing Mao

submission deadline 28 Feb 2026 | Viewed by 360 | Submission Open

Keywords: toxicometabolomics; metabolite markers; xenobiotic metabolism; endogenous metabolism; microbial metabolism; metabolic activation; metabolic detoxification

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Metabolic Syndrome in Polycystic Ovary Syndrome

edited by Sebastiao Freitas De Medeiros and

Alice S. Ryan

submission deadline 28 Feb 2026 | Viewed by 218 | Submission Open

Keywords: cardiovascular disease; dyslipidemia; hyperandrogenism; hyperinsulinemia; hypertension; metabolic syndrome; polycystic ovary syndrome; visceral obesity

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Exploring Metabolomic Signatures and the Metabolic Impact of Thyroid Dysfunction

edited by Janine Wirth

submission deadline 28 Feb 2026 | Viewed by 215 | Submission Open

Keywords: thyroid function; hypothyroidism; hyperthyroidism; Hashimoto; metabolic health; metabolomics; inflammation; autoimmune

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Pharmacodynamics and Innovative Therapeutic Strategies for Metabolic Disorders

edited by

Josué V. Espinosa-Juárez

Osmar Antonio Jaramillo-Morales

and

Victor Gault

submission deadline 28 Feb 2026 | Viewed by 213 | Submission Open

Keywords: pharmacology; experimental therapeutics; metabolic diseases; drug development; therapeutic innovations; metabolic pathways; pharmacodynamics; disease management

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Advances in Cancer Metabolism

edited by Haowen Jiang,

Man Zhao

and

Duo Zhang

submission deadline 28 Feb 2026 | Viewed by 193 | Submission Open

Keywords: cancer metabolism; metabolic plasticity; tumor microenvironment; immunometabolism; mitochondrial metabolism; oncometabolites; metabolic– epigenetic crosstalk; single-cell metabolomics; spatial metabolomics; metabolic flux analysis

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Applications of Mass Spectrometry in Elucidating Human Drug Metabolism: From the Preclinical Phase to Real-World Studies

edited by

Frank Klont

submission deadline 1 Mar 2026 | 2 articles | Viewed by 2082 | Submission Open

Keywords: drug metabolism; liquid chromatography; mass balance studies; mass spectrometry; metabolite profiling; metabolomics; personalized medicine; pharmacogenetics; pharmacometabolomics; pharmacy

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Metabolomics in Infectious Diseases

edited by

María Ángeles Jiménez Sousa

and

Rubén Martín-Escolano

submission deadline 1 Mar 2026 | Viewed by 215 | Submission Open

Keywords: metabolomics; infectious diseases; pathogenesis; prognosis; biomarkers; host– pathogen interaction; therapeutic targets; diagnosis

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Research on Metabolic Biomarkers in Different Diseases

edited by Xiaohui Liu

submission deadline 16 Mar 2026 | Viewed by 111 | Submission Open

Keywords: metabolomics; biomarkers; diseases; methodology; bioinformatics

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

The Role of Gene–Environment Interactions in Metabolic Dysregulation in Osteochondral Disease Pathogenesis

edited by Xi Wang and

Lei Yang

submission deadline 16 Mar 2026 | Viewed by 82 | Submission Open

Keywords: metabolic pathology; osteochondral diseases; gene– environment interactions; environmental exposures; metabolic dysregulation

(This special issue belongs to the Section Environmental Metabolomics)

Bioactive Metabolites from Natural Sources (2nd Edition)

edited by

Miroslava Zhiponova

and Zhenya P. Yordanova

submission deadline 31 Mar 2026 | 5 articles | Viewed by 16035 | Submission Open

Keywords: primary metabolites; secondary metabolites; nature-based synthetic molecules; molecular mechanisms; models; evolution; food; agriculture; health; in vitro biological activities; in vivo biological activities

(This special issue belongs to the Section Plant Metabolism)

Obesity and Metabolic Dysfunction: Disease Development and Breaking the Cycle

edited by Paulo Cezar de Freitas Mathias, Lucas Paulo Jacinto Saavedra and

Rodrigo Mello Gomes

submission deadline 31 Mar 2026 | 4 articles | Viewed by 12628 | Submission Open

Keywords: obesity; diabetes; DOHaD; metabolic programming; treatment; intervention; cardiovascular disease; metabolic syndrome

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Advances in Metabolomics and Multi-Omics Integration

edited by

Kurt K. Zhang

submission deadline 31 Mar 2026 | 5 articles | Viewed by 9690 | Submission Open

Keywords: metabolomics; cellular metabolism; multi-omics; metabolites; molecular interaction; cell– cell cross-talk

(This special issue belongs to the Section Integrative Metabolomics)

Nutrition, Metabolism and Physiology in Aquatic Animals

edited by

Renlei Ji

and Xueshan Li

submission deadline 31 Mar 2026 | 5 articles | Viewed by 9591 | Submission Open

Keywords: nutrition; metabolism; physiology; metabolism; aquaculture; metabolome; nutrients; hazardous materials

(This special issue belongs to the Section Nutrition and Metabolism)

Displaying special issue 51-100 on page 2 of 6.

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