Synthetic Biology Approaches for Expanding the Metabolic Capabilities of E. coli
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Microbiology and Ecological Metabolomics".
Deadline for manuscript submissions: 31 May 2025 | Viewed by 261
Special Issue Editors
Interests: metabolic engineering; synthetic biology
2. Department of Convergence Science, College of Medicine, Catholic Kwandong University, Gangneung-si 25601, Gang-won-do, Republic of Korea
Interests: alcohol-related liver disease; trimethylamine N-oxide; serum metabolites; multivariate analysis; 1H-NMR
Special Issue Information
Dear Colleagues,
Synthetic biology, an emerging field at the intersection of biology, engineering, and computation, has revolutionized our ability to redesign and repurpose biological systems for various applications. One of the primary targets for synthetic biology interventions is the bacterium Escherichia coli, owing to its well-understood genetics, fast growth rate, and amenability to genetic manipulation. This article explores various synthetic biology approaches aimed at expanding the metabolic capabilities of E. coli.
These approaches encompass a broad range of strategies, including the introduction of novel metabolic pathways, the optimization of existing pathways, and the construction of artificial metabolic networks. Researchers leverage advanced tools such as genome editing technologies (e.g., CRISPR-Cas9), metabolic engineering, and computational modeling to design and implement precise genetic modifications that enhance E. coli’s ability to produce desired compounds, degrade toxic pollutants, or even perform novel metabolic feats.
This Special Issue highlights the potential of these approaches in areas like biofuels production, the biosynthesis of high-value chemicals and pharmaceuticals, bioremediation, and environmental sensing. By harnessing the power of synthetic biology, scientists are pushing the boundaries of what E. coli can achieve, transforming it into a versatile microbial cell factory with applications spanning multiple industries.
Dr. Angelo Bañares
Dr. Kei Anne Baritugo
Guest Editors
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Keywords
- synthetic biology
- Escherichia coli (E. coli)
- metabolic engineering
- genome editing (crispr-cas9)
- novel metabolic pathways
- high-value chemicals
- biofuels
- bioremediation
- environmental sensing
- microbial cell factory
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