Exploring Metabolomic Signatures and the Metabolic Impact of Thyroid Dysfunction
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 22
Special Issue Editor
Interests: public health; nutritional epidemiology; metabolic health; protein intake; intervention studies; cohort studies; systematic reviews
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Thyroid hormones are important regulators of metabolism and can influence energy balance, thermogenesis, lipid and glucose homeostasis, and protein metabolism. Alterations in thyroid function can significantly impact metabolic health and are associated with cardiometabolic disorders, weight dysregulation, and changes in body composition. Individual variability, possibly due to genetic factors, the gut microbiome, or unknown metabolic compensations, presents a particular challenge.
Recent metabolomic studies have identified patterns of metabolic disturbances in hypothyroidism, but interpreting which disturbances cause which symptoms is not always straightforward. Metabolomic approaches have great potential to uncover hidden or poorly understood mechanisms linking hypothyroidism to its diverse symptoms beyond conventional thyroid hormone testing. By capturing detailed metabolite profiles, metabolomics can help to uncover the tissue-specific effects of thyroid hormone deficiency, identify disrupted metabolic pathways, and monitor their alteration through treatments/interventions.
Of particular interest is the relationship between thyroid status, metabolic profiles, and other relevant comorbidities or symptoms associated with thyroid dysfunction (e.g., depression, cardiovascular disease, impaired libido, or hair loss).
The aim of this Special Issue is to investigate the interactions between thyroid physiology, dysfunction, and treatment and metabolic health using traditional biomarkers and new omics technologies. We invite the submission of original research, clinical studies, and systematic reviews addressing one or more of the following areas:
- Metabolic and metabolomic profiling in hypothyroidism or hyperthyroidism;
- The role of thyroid hormones in regulating specific metabolic pathways;
- Metabolic response to thyroid treatment (pharmacological or non-pharmacological);
- Interactions between thyroid function, diet, and nutrient metabolism;
- Longitudinal studies on the relationship between thyroid status and metabolic risk.
We welcome your contributions to unravel the complex relationships between thyroid function and metabolism.
Dr. Janine Wirth
Guest Editor
Manuscript Submission Information
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Keywords
- thyroid function
- hypothyroidism
- hyperthyroidism
- Hashimoto
- metabolic health
- metabolomics
- inflammation
- autoimmune
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