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Special Issue "Biomaterials and Implant Biocompatibility"
Deadline for manuscript submissions: 31 October 2019.
Department of Biochemistry and Molecular Biology,Universitatea din Bucuresti,Bucuresti,Romania
Interests: biomaterials and biocompatibility; tissue engineering; stem cells and regenerative medicine; cell biology; clinical biochemistry
Special Issues and Collections in MDPI journals
Politehnica University of Bucharest, Department of Metallic Materials Science and Physical Metallurgy
Interests: synthesis and characterization of biomaterials; design and development of biomedical devices for bone reconstruction; membrane and thin film materials
Special Issues and Collections in MDPI journals
The scientific advances in life sciences and engineering constantly challenge, expand and redefine the concepts related to biocompatibility and safety of medical devices. New biomaterials, new products and new testing regimes are introduced in the scientific research practices. In order to provide clinically predictive results and to ensure a high benefit-risk ratio for the patients we need to optimize the material and implant characteristics, and to adapt the performance and safety evaluation practices for these innovative medical devices.
Various characteristics related to materials and implant development such as raw materials composition, implants surface morphology, design, geometry, porosity and mechanical properties need to be thoroughly characterized before the evaluation of implants biological performance. Furthermore, with the increase of regulatory demands, biological evaluation needs to ensure appropriate models and methods for each implant development stage.
This Special Issue of Materials (ISSN 1996-1944) on "Biomaterials and Implant Biocompatibility” aims to focus on the recent progress in development, material testing, and biocompatibility and bioactivity evaluation of various materials including, but not limited to, bioceramics, biopolymers, biometals, composite materials, biomimetic materials, hybrid biomaterials and drug/device combinations for implants and prostheses with medical applications spanning from soft to hard tissue regeneration. Submitted manuscripts may cover all aspects, ranging from investigations into material characterization to in vitro and in vivo testing for the assessment of biological performance of advanced, novel biomaterials and implants.
We invite all colleagues to submit manuscripts (full papers, reviews or notes) in open access to this Special Issue. We encourage you to disseminate this invitation to any colleagues who may be interested.
Prof. Anişoara Cîmpean
Prof. Florin Miculescu
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- composite materials
- hybrid material
- drug-releasing implants
- in vitro testing
- in vivo testing
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
The serum protein profile and acute phase proteins in the postoperative period in sheep after induced articular cartilage defect
Csilla Tothova 1, Xenia Mihajlovicova 1, Jaroslav Novotny 2, Oskar Nagy 1, Maria Giretova 3,4, Marek Tomco 4, Zdenek Zert 5, Zuzana Vilhanova 5, Maros Varga 6, Lubomir Medvecky 3 and Eva Petrovova 4,*
1 Clinic of Ruminants, University of Veterinary Medicine and Pharmacy in Kosice, Komenskeho 73, 041 81 Kosice, Slovak Republic; [email protected] (C.T.); [email protected] (X.M.); [email protected] (O.N.)
2 Clinic of Swine, University of Veterinary Medicine and Pharmacy in Kosice, Komenskeho 73, 041 81 Kosice, Slovak Republic; Jaroslav [email protected] (J.N.)
4 Institute of Anatomy, University of Veterinary Medicine and Pharmacy in Kosice, Komenskeho 73, 041 81 Kosice, Slovak Republic; [email protected] (M.G.); [email protected] (M.T.); [email protected] (E.P.)
2 Sport-arthro Centre, Privat Hospital Saca-Kosice, Lucna 57, 040 15 Kosice-Saca, Slovak Republic; [email protected] (M.V.)
* Correspondence: [email protected]; Tel.: +421-917-637-799
Received: date; Accepted: date; Published: date
Abstract: Although several new implants have been demonstrated using animal studies for the treatment of osteochondral and cartilage defects, including the histological evaluation of the cartilage repair and maturation of the newly-formed cartilage. However, there is a lack of information on the possible metabolic and biochemical reactions of the body to the implantation of biomaterials and cartilage reconstruction in the animal model. Therefore, this study is focused on evaluation of the serum protein pattern and the alterations in the concentrations of selected acute phase proteins in sheep before and after the reconstruction of experimentally induced articular cartilage defects using polyhydroxybutyrate/chitosan-based biopolymer material. Into the evaluation, we included five clinically healthy female sheep of the crossbreed of Merino and Valachian sheep at the age of 2 years and in good nutritional condition. The concentrations of total serum proteins (TSP), protein fractions and selected acute phase proteins - serum amyloid A (SAA), haptoglobin (Hp) and C-reactive protein (CRP) were measured before and on day 7, 14, and 30 after the surgical intervention. The TSP concentrations showed no marked differences during the evaluated period. Albumin values decreased on day 7 and 14 after surgery. In the concentrations of 1-, 2-, β- and 2-globulins a gradual significant increase was observed during the postoperative period (P < 0.05). The 1-globulins decreased slightly 7 days after surgery, with a subsequent gradual increase to preoperative values. The SAA values increased 7 days after the surgical intervention (P < 0.01) and decreased from day 14. In the concentrations of Hp, a more gradual increase was found until the day 14 after surgery, with the subsequent decrease on day 30. The values of CRP increased significantly until the day 14 after surgery (P < 0.05). Presented results suggest marked alterations in the serum protein pattern after surgical intervention characterized by changes in most serum proteins fractions and evaluated acute phase protein concentrations.
Keywords: articular cartilage defect; bioplolymers; C-reactive protein; haptoglobin; in vivo testing; serum amyloid A; serum protein fractions; sheep