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Materials 2019, 12(1), 142; https://doi.org/10.3390/ma12010142

The Serum Protein Profile and Acute Phase Proteins in the Postoperative Period in Sheep after Induced Articular Cartilage Defect

1
Clinic of Ruminants, University of Veterinary Medicine and Pharmacy in Kosice, Komenskeho 73, 041 81 Kosice, Slovakia
2
Clinic of Swine, University of Veterinary Medicine and Pharmacy in Kosice, Komenskeho 73, 041 81 Kosice, Slovakia
3
Institute of Materials Research SAS in Kosice, Watsonova 47, 040 01 Kosice, Slovakia
4
Institute of Anatomy, University of Veterinary Medicine and Pharmacy in Kosice, Komenskeho 73, 041 81 Kosice, Slovakia
5
Clinic of Horses, University of Veterinary Medicine and Pharmacy in Kosice, Komenskeho 73, 041 81 Kosice, Slovakia
6
Sport-Arthro Centre, Privat Hospital Kosice-Saca, Lucna 57, 040 15 Kosice-Saca, Slovakia
*
Author to whom correspondence should be addressed.
Received: 8 December 2018 / Revised: 26 December 2018 / Accepted: 27 December 2018 / Published: 3 January 2019
(This article belongs to the Special Issue Biomaterials and Implant Biocompatibility)
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Abstract

Although several new implants have been developed using animal studies for the treatment of osteochondral and cartilage defects, there is a lack of information on the possible metabolic and biochemical reactions of the body to the implantation of biomaterials and cartilage reconstruction. Therefore, this study was aimed at evaluating the serum protein pattern and the alterations in the concentrations of selected acute phase proteins in five clinically healthy female sheep before and after the reconstruction of experimentally induced articular cartilage defects using polyhydroxybutyrate/chitosan based biopolymer material. The concentrations of total serum proteins (TSP), protein fractions, and selected acute phase proteins—serum amyloid A (SAA), haptoglobin (Hp), and C-reactive protein (CRP)—were measured before and on days seven, 14, and 30 after the surgical intervention. The TSP concentrations showed no marked differences during the evaluated period. Albumin values decreased on day seven and day 14 after surgery. In the concentrations of α1-, α2-, β-, and γ2-globulins, a gradual significant increase was observed during the postoperative period (p < 0.05). The γ1-globulins decreased slightly seven days after surgery. The concentrations of SAA, Hp, and CRP increased significantly after the surgical intervention with a subsequent decrease on day 30. Presented results suggest marked alterations in the serum protein pattern after surgical intervention. View Full-Text
Keywords: articular cartilage defect; bioplolymers; C-reactive protein; haptoglobin; in vivo testing; serum amyloid A; serum protein fractions; sheep articular cartilage defect; bioplolymers; C-reactive protein; haptoglobin; in vivo testing; serum amyloid A; serum protein fractions; sheep
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Tothova, C.; Mihajlovicova, X.; Novotny, J.; Nagy, O.; Giretova, M.; Kresakova, L.; Tomco, M.; Zert, Z.; Vilhanova, Z.; Varga, M.; Medvecky, L.; Petrovova, E. The Serum Protein Profile and Acute Phase Proteins in the Postoperative Period in Sheep after Induced Articular Cartilage Defect. Materials 2019, 12, 142.

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