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Open AccessArticle

3D Superparamagnetic Scaffolds for Bone Mineralization under Static Magnetic Field Stimulation

1
Center for Advanced Laser Technologies (CETAL), National Institute for Laser, Plasma and Radiation Physics, RO-077125 Magurele-Ilfov, Romania
2
Physics Department, Faculty of Applied Sciences, University Politehnica of Bucharest, RO-060042 Bucharest, Romania
3
Horia Hulubei National Institute for Physics and Nuclear Engineering IFIN-HH, RO-077125 Magurele-Ilfov, Romania
4
National Institute for Laser, Plasma and Radiation Physics, RO-077125 Magurele-Ilfov, Romania
5
National Institute of Materials Physics, RO-077125 Magurele-Ilfov, Romania
*
Author to whom correspondence should be addressed.
Materials 2019, 12(17), 2834; https://doi.org/10.3390/ma12172834
Received: 7 July 2019 / Revised: 20 August 2019 / Accepted: 26 August 2019 / Published: 3 September 2019
(This article belongs to the Special Issue Biomaterials and Implant Biocompatibility)
We reported on three-dimensional (3D) superparamagnetic scaffolds that enhanced the mineralization of magnetic nanoparticle-free osteoblast cells. The scaffolds were fabricated with submicronic resolution by laser direct writing via two photons polymerization of Ormocore/magnetic nanoparticles (MNPs) composites and possessed complex and reproducible architectures. MNPs with a diameter of 4.9 ± 1.5 nm and saturation magnetization of 30 emu/g were added to Ormocore, in concentrations of 0, 2 and 4 mg/mL. The homogenous distribution and the concentration of the MNPs from the unpolymerized Ormocore/MNPs composite were preserved after the photopolymerization process. The MNPs in the scaffolds retained their superparamagnetic behavior. The specific magnetizations of the scaffolds with 2 and 4 mg/mL MNPs concentrations were of 14 emu/g and 17 emu/g, respectively. The MNPs reduced the shrinkage of the structures from 80.2 ± 5.3% for scaffolds without MNPs to 20.7 ± 4.7% for scaffolds with 4 mg/mL MNPs. Osteoblast cells seeded on scaffolds exposed to static magnetic field of 1.3 T deformed the regular architecture of the scaffolds and evoked faster mineralization in comparison to unstimulated samples. Scaffolds deformation and extracellular matrix mineralization under static magnetic field (SMF) exposure increased with increasing MNPs concentration. The results are discussed in the frame of gradient magnetic fields of ~3 × 10−4 T/m generated by MNPs over the cells bodies. View Full-Text
Keywords: superparamagnetic scaffold; composite; laser direct writing; static magnetic field; extracellular matrix mineralization superparamagnetic scaffold; composite; laser direct writing; static magnetic field; extracellular matrix mineralization
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MDPI and ACS Style

Paun, I.A.; Calin, B.S.; Mustaciosu, C.C.; Mihailescu, M.; Moldovan, A.; Crisan, O.; Leca, A.; Luculescu, C.R. 3D Superparamagnetic Scaffolds for Bone Mineralization under Static Magnetic Field Stimulation. Materials 2019, 12, 2834.

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