Next Article in Journal
In-Situ Observation of Fracture Behavior of Ti-Aluminide Multi-Layered Composites Produced by a Hybrid Sintering Process
Previous Article in Journal
Physical Hydrogels of Oxidized Polysaccharides and Poly(Vinyl Alcohol) for Wound Dressing Applications
Previous Article in Special Issue
Impact of Gentamicin-Loaded Bone Graft on Defect Healing in a Sheep Model
Article Menu
Issue 9 (May-1) cover image

Export Article

Open AccessArticle

Preparing Sodium Alginate/Polyethyleneimine Spheres for Potential Application of Killing Tumor Cells by Reducing the Concentration of Copper Ions in the Lesions of Colon Cancer

1
School of Life Science, Zhengzhou University, Zhengzhou 450000, China
2
School of Material Science and Engineering & Henan Key Laboratory of Advanced Magnesium Alloy & Key Laboratory of materials processing and mold technology (Ministry of Education), Zhengzhou University, Zhengzhou 450001, China
*
Authors to whom correspondence should be addressed.
Materials 2019, 12(9), 1570; https://doi.org/10.3390/ma12091570
Received: 8 April 2019 / Revised: 9 May 2019 / Accepted: 10 May 2019 / Published: 13 May 2019
(This article belongs to the Special Issue Biomaterials and Implant Biocompatibility)
  |  
PDF [5268 KB, uploaded 14 May 2019]
  |  

Abstract

Inhibition of residual malignant tumors in patients with colon cancer after operation is one of the difficulties in rehabilitation treatment. At present, using biocompatible materials to remove the copper ion which is the growth dependence of malignant tumors in the lesion site is considered to be the frontier means to solve this problem. In this work, we developed a sodium alginate (SA)/polyethyleneimine (PEI) hydrogel sphere via cross-linking method (SA/SP/SA; SP = SA/PEI) as an oral biomaterial for adsorbing and removing copper ions from colon cancer lesions. The evaluated results showed that the SA/PEI/SA (SPS) hydrogel sphere obtained the largest swelling rate at pH 8.3 which was the acid-base value of colon microenvironment and absorbed more copper ions compared with the SA control. The cell experiment presented that the SPS hydrogel sphere owned better compatibility on normal fibroblasts and promoted higher death of colon cancer cells compared with SA/PEI (SP) and SA control. Our data suggested that the SA/PEI hydrogel sphere had the potentiality as an oral biomaterial for inhibiting colon cancer cells. View Full-Text
Keywords: colon cancer cells; copper ions; hydrogel sphere; sodium alginate; polyethyleneimine colon cancer cells; copper ions; hydrogel sphere; sodium alginate; polyethyleneimine
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Xu, R.; Su, C.; Cui, L.; Zhang, K.; Li, J. Preparing Sodium Alginate/Polyethyleneimine Spheres for Potential Application of Killing Tumor Cells by Reducing the Concentration of Copper Ions in the Lesions of Colon Cancer. Materials 2019, 12, 1570.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top