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Materials 2019, 12(6), 866; https://doi.org/10.3390/ma12060866

Bactericidal and Biocompatible Properties of Plasma Chemical Oxidized Titanium (TiOB®) with Antimicrobial Surface Functionalization

1
Department of Conservative Dentistry and Periodontology, University Hospital Jena, An der Alten Post 4, 07743 Jena, Germany
2
Innovent Technology Development, Prüssingstraße 27 B, 07745 Jena, Germany
3
Königsee Implantate GmbH, OT-Aschau—Am Sand 4, 07426 Allendorf, Germany
4
Department of Microbiology, University Hospital Jena, Erlanger Allee 101, 07747 Jena, Germany
5
Department of Trauma-, Hand- and Reconstructive Surgery, University Hospital Jena, Erlanger Allee 101, 07747 Jena, Germany
*
Author to whom correspondence should be addressed.
Received: 14 February 2019 / Revised: 7 March 2019 / Accepted: 11 March 2019 / Published: 15 March 2019
(This article belongs to the Special Issue Biomaterials and Implant Biocompatibility)
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Abstract

Coating of plasma chemical oxidized titanium (TiOB®) with gentamicin-tannic acid (TiOB® gta) has proven to be efficient in preventing bacterial colonization of implants. However, in times of increasing antibiotic resistance, the development of alternative antimicrobial functionalization strategies is of major interest. Therefore, the aim of the present study is to evaluate the antibacterial and biocompatible properties of TiOB® functionalized with silver nanoparticles (TiOB® SiOx Ag) and ionic zinc (TiOB® Zn). Antibacterial efficiency was determined by agar diffusion and proliferation test on Staphylocuccus aureus. Cytocompatibility was analyzed by direct cultivation of MC3T3-E1 cells on top of the functionalized surfaces for 2 and 4 d. All functionalized surfaces showed significant bactericidal effects expressed by extended lag phases (TiOB® gta for 5 h, TiOB® SiOx Ag for 8 h, TiOB® Zn for 10 h). While TiOB® gta (positive control) and TiOB® Zn remained bactericidal for 48 h, TiOB® SiOx Ag was active for only 4 h. After direct cultivation for 4 d, viable MC3T3-E1 cells were found on all surfaces tested with the highest biocompatibility recorded for TiOB® SiOx Ag. The present study revealed that functionalization of TiOB® with ionic zinc shows bactericidal properties that are comparable to those of a gentamicin-containing coating. View Full-Text
Keywords: titanium implants; dental implants; antibacterial coating; gentamicin; silver; zinc; cytotoxicity; MC3T3-E1; Staphylococcus aureus; plasma chemical oxidation titanium implants; dental implants; antibacterial coating; gentamicin; silver; zinc; cytotoxicity; MC3T3-E1; Staphylococcus aureus; plasma chemical oxidation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Kranz, S.; Guellmar, A.; Voelpel, A.; Lesser, T.; Tonndorf-Martini, S.; Schmidt, J.; Schrader, C.; Faucon, M.; Finger, U.; Pfister, W.; Diefenbeck, M.; Sigusch, B. Bactericidal and Biocompatible Properties of Plasma Chemical Oxidized Titanium (TiOB®) with Antimicrobial Surface Functionalization. Materials 2019, 12, 866.

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