Special Issues

Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Migraine and Headache: From Pathophysiological Aspects
edited by
submission deadline 30 Jul 2026 | 3 articles | Viewed by 4234 | Submission Open
Keywords: migraine; headache; pathophysiology; treatment; medication
(This special issue belongs to the Section Physiology and Pathology)
Prostate Cancer: 4th Edition submission deadline 30 Jul 2026 | 2 articles | Viewed by 3718 | Submission Open
Keywords: incidence; mortality; diagnosis; histopathology; imaging; treatment; prognosis; case report; animals; humans; modeling
(This special issue belongs to the Section Medical Research)
Advances in Fetal Medicine: From Prenatal Diagnosis to Fetal and Neonatal Therapy
edited by Przemysław Kosinski
submission deadline 30 Jul 2026 | 2 articles | Viewed by 1759 | Submission Open
Keywords: fetal medicine; prenatal diagnosis; non-invasive prenatal testing (NIPT); fetal imaging; fetal therapy; fetal surgery; neonatal intensive care; genetic and genomic advances; perinatal outcomes; maternal-fetal health
(This special issue belongs to the Section Reproductive and Developmental Biology)
Therapeutic Effects of Natural Products on Human Diseases—3rd Edition
edited by
submission deadline 30 Jul 2026 | 1 articles | Viewed by 731 | Submission Open
Keywords: natural products; natural extracts; cancer; neurodegenerative diseases; immunological disorders; metabolic diseases; oriental medicine; microorganisms; algae; functional foods
(This special issue belongs to the Section Pharmaceutical Science)
Treatment and Prognosis of Thoracic Diseases submission deadline 30 Jul 2026 | 1 articles | Viewed by 643 | Submission Open
Keywords: thoracic malignancies; lung cancer management  ; targeted therapy  ; immunotherapy  ; molecular diagnostics  ; multidisciplinary care  ; personalized treatment
(This special issue belongs to the Section Medical Research)
Recent Advances in Bone Biology
edited by Barbara Peruzzi, and Giulia Battafarano
submission deadline 30 Jul 2026 | 1 articles | Viewed by 600 | Submission Open
Keywords: bone tissue engineering; bone-targeted therapies; genetic bone diseases; bone mechanotransduction; bone cell pathophysiology; bone metabolism
(This special issue belongs to the Section Physiology and Pathology)
Migraine and Headache: From Clinical and Therapeutic Aspects
edited by
submission deadline 30 Jul 2026 | Viewed by 251 | Submission Open
Keywords: migraine; headache; treatment; medication
(This special issue belongs to the Section Medical Research)
Advances and Applications of Sport Physiology: 2nd Edition
edited by and
submission deadline 31 Jul 2026 | 5 articles | Viewed by 8267 | Submission Open
Keywords: sports medicine; strength and conditioning; diagnostics; sport injuries; performance analysis
(This special issue belongs to the Section Physiology and Pathology)
Microorganisms Engineering and Gene-Editing Methods
edited by , and Xia Zhao
submission deadline 31 Jul 2026 | 1 articles | Viewed by 1562 | Submission Open
Keywords: microorganisms engineering; metabolic engineering; strain optimization; gene editing; CRISPR; recombination
(This special issue belongs to the Section Genetics and Genomics)
Sports Biomechanics, Injury, and Physiotherapy
edited by Manos Stefanakis
submission deadline 31 Jul 2026 | 2 articles | Viewed by 1382 | Submission Open
Keywords: sports injuries; epidemiology; data-driven rehabilitation; objective assessment; injury prevention; return to play
(This special issue belongs to the Section Physiology and Pathology)
Vetinformatics-Driven Approaches to Animal Health and Disease submission deadline 31 Jul 2026 | 1 articles | Viewed by 772 | Submission Open
Keywords: animal health; livestock disease; vetinformatics; computational genomics; RNAseq; multi-omics; drug discovery; molecular docking; molecular dynamics simulation; vaccine design; one health
(This special issue belongs to the Section Animal Science)
Innovation in Fish Nutrition, Production Technology, and Welfare
edited by , Liviu-Dan Miron and
submission deadline 31 Jul 2026 | Viewed by 547 | Submission Open
Keywords: aquaculture; fish nutrition; fish welfare; water quality; fish disease; feed additives; rearing systems; modern feeding technologies; waste management
Skin Care and Innovation from the Perspective of Molecular Dermatology submission deadline 31 Jul 2026 | Viewed by 459 | Submission Open
Keywords: molecular dermatology; personalised skincare; ageing; natural ingredients
(This special issue belongs to the Section Physiology and Pathology)
Multimodal AI for Genomic-Clinicopathologic Integration: From Preventive Screening to Precision Diagnosis
edited by Yen-Lin Chen
submission deadline 31 Jul 2026 | Viewed by 120 | Submission Open
Keywords: multimodal data integration; artificial intelligence in medicine; genomic and health data analysis; digital pathology and image analysis; predictive modeling and risk stratification; explainable machine learning (XAI)
(This special issue belongs to the Section Biochemistry, Biophysics and Computational Biology)
Anti-Inflammatory and Natural Products
edited by
submission deadline 31 Jul 2026 | Viewed by 106 | Submission Open
Keywords: anti-inflammation; macrophage; mechanism study; in vivo/in vitro model; natural products; natural products-derived compound
(This special issue belongs to the Section Pharmaceutical Science)
Genetic Regulation Mechanisms of Crop Salt–Alkali Tolerance
edited by
submission deadline 31 Jul 2026 | Viewed by 61 | Submission Open
Keywords: crops; salt tolerance; genome; transcriptome; yield traits; genetic regulation mechanisms
(This special issue belongs to the Section Plant Science)
Precision Oncology Through Diagnostic Imaging and Theranostics
edited by , Luyuan Li and Yu-Ping Yang
submission deadline 31 Jul 2026 | Viewed by 58 | Submission Open
Keywords: cancer imaging; molecular imaging; theranostics; nanomedicine; imaging biomarkers; precision oncology
(This special issue belongs to the Section Medical Research)
Molecular Mechanisms and Immune Regulation in Animal Diseases
edited by
submission deadline 31 Jul 2026 | Viewed by 54 | Submission Open
Keywords: proteomics; animal diseases; mucosal immunity; biomarkers; host– pathogen interactions; immunoregulation; mass spectrometry; comparative medicine; veterinary proteomics; systems biology
(This special issue belongs to the Section Animal Science)
Compulsive Disorder: Understanding of the Pathophysiology and Therapeutic Implications submission deadline 31 Jul 2026 | Viewed by 46 | Submission Open
Keywords: obsessive– compulsive disorder; compulsivity; cortico-striato-thalamo cortical circuits; cognitive inflexibility; glutamatergic modulation; neuroimmune mechanisms; neuromodulation; deep brain stimulation; precision psychiatry
(This special issue belongs to the Section Physiology and Pathology)
Black Holes in Atrial Fibrillation Therapy
edited by Roberto Cemin
submission deadline 31 Jul 2026 | Viewed by 46 | Submission Open
Keywords: atrial fibrillation; clinical guidelines; stroke prevention; oral anticoagulation; CHA2DS2-Va Score; catheter ablation; left atrial appendage closure; personalized medicine
(This special issue belongs to the Section Medical Research)
Mechanisms and Treatment of Eye and Vision Conditions
edited by Jeong-Min Hwang
submission deadline 31 Jul 2026 | Viewed by 45 | Submission Open
Keywords: mechanism; treatment; eye; vision
(This special issue belongs to the Section Medical Research)
Building the Future of Veterinary Medicine: Foundational Data in Physiology and Pathology
edited by Bokyeong Ryu
submission deadline 31 Jul 2026 | Viewed by 38 | Submission Open
Keywords: veterinary physiology; veterinary pathology; veterinary database; multimodal evidence
(This special issue belongs to the Section Animal Science)
Prevention and Control of Post-Radiotherapy Complications in Head and Neck Cancer
edited by Sung-Chan Shin
submission deadline 31 Jul 2026 | Viewed by 34 | Submission Open
Keywords: head and neck cancer; radiotherapy complications; post-radiation toxicity; radiation-induced injury; prevention and management; oral and pharyngeal toxicity; salivary gland dysfunction; osteoradionecrosis; functional rehabilitation; biomarkers and prediction models
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Precision Medicine in Heart Failure: From Biomarkers to Targeted Therapies
edited by
submission deadline 31 Jul 2026 | Viewed by 10 | Submission Open
Keywords: heart failure; precision medicine; biomarkers; multi-omics; personalized therapy; cardiovascular imaging; genetic profiling; artificial intelligence; risk stratification; targeted therapies
(This special issue belongs to the Section Medical Research)
Novel Insights for Spinal Pain Management: From Physical Therapies to Ultrasound-Guided Procedures submission deadline 31 Jul 2026 | Viewed by 9 | Submission Open
Keywords: spine; pain; physical therapies; rehabilitation; ultrasound; procedures
(This special issue belongs to the Section Medical Research)
Skin Models and 3D Tissue: Fungal Infections and Antifungals
edited by Marisa Meloni, and Antonio Del Prete
submission deadline 5 Aug 2026 | Viewed by 38 | Submission Open
Keywords: mycosis; 3D tissue in vitro models; clinical and non clinical models; antifungal therapy
(This special issue belongs to the Section Microbiology)
Challenges and Innovations in Biomaterials for Tissue Engineering
edited by , Donny Hanjaya-Putra and Loan Bui
submission deadline 20 Aug 2026 | Viewed by 113 | Submission Open
Keywords: hydrogels; nanoparticles; extracellular matrix; microfluidics; bio-responsive; tissue engineering; regenerative medicine
(This special issue belongs to the Section Cell Biology and Tissue Engineering)
Recent Advances in Head and Neck Disorders
edited by and Maximilian Dindelegan
submission deadline 20 Aug 2026 | Viewed by 89 | Submission Open
Keywords: molecular pathology; biomedical technology; systems biology
(This special issue belongs to the Section Medical Research)
Spotlight on Cardiovascular Physiology and Related Diseases: Impact of Sex Differences
edited by
submission deadline 21 Aug 2026 | Viewed by 34 | Submission Open
Keywords: cardiovascular physiology; microcirculation; endothelium; oxidative stress; sex differences; mathematical algorithms for biological signal analysis; metabolic diseases; hyperglycemia
(This special issue belongs to the Section Medical Research)
Oral Health and Systemic Conditions: From Biological Insights to Multidimensional Interventions submission deadline 27 Aug 2026 | Viewed by 244 | Submission Open
Keywords: oral health  ; periodontitis  ; dental care  ; tooth loss  ; oral cancer  ; facial esthetics  ; salivary biomarkers  ; systemic– oral health interactions  ; non-invasive therapies  ; clinical and epidemiological research
(This special issue belongs to the Section Medical Research)
Root–Soil–Microbe Interactions: Mechanisms and Management for Plant Performance and Ecosystem Function
edited by
submission deadline 28 Aug 2026 | Viewed by 11 | Submission Open
Keywords: Root– soil– microbe interactions; Rhizosphere processes; Plant– microbe networks; Biogeochemical cycling; Microbiome-informed management
(This special issue belongs to the Section Plant Science)
Molecular Muscle Adaptations Across the Lifespan
edited by S. Kyle Traivs and
submission deadline 30 Aug 2026 | 1 articles | Viewed by 4366 | Submission Open
Keywords: muscle tissue; muscle physiology; molecular pathways; therapeutics
(This special issue belongs to the Section Physiology and Pathology)
Skin Diseases and Dermatologic Comorbidities
edited by Alessia Paganelli, and
submission deadline 30 Aug 2026 | 3 articles | Viewed by 4242 | Submission Open
Keywords: skin diseases; dermatologic comorbidities; metabolic impairment; autoimmunity; cytokines; serum markers
(This special issue belongs to the Section Physiology and Pathology)
Metabolic Eye Diseases: From Tomography to Clinical Prediction submission deadline 30 Aug 2026 | Viewed by 305 | Submission Open
Keywords: metabolic eye diseases; ophthalmic tomography and imaging biomarkers; diabetic retinopathy and systemic metabolic disorders; mitochondrial dysfunction and optic neuropathies; corneal metabolic diseases and ocular surface disorders; artificial intelligence in clinical prediction of eye diseases; metabolic pathways and retinal degeneration; translational research in metabolic ophthalmology
(This special issue belongs to the Section Physiology and Pathology)
Endocrine Mechanisms and Cellular Dynamics in Obesity: Insights and Innovations
edited by Manuel Gil Lozano and Marina Romaní-Pérez
submission deadline 30 Aug 2026 | Viewed by 278 | Submission Open
Keywords: gastrointestinal peptides; adipokines; food intake regulation; hypothalamus; orexigenic; anorexigenic; adipocytes; pancreatic islets; leptin; insulin
(This special issue belongs to the Section Physiology and Pathology)
Global Burden of Chronic Pain: Advances and Challenges in Pain Management and Clinical Practice
edited by Saba Javed and Billy Huh
submission deadline 30 Aug 2026 | 1 articles | Viewed by 119 | Submission Open
Keywords: chronic pain syndrome; cancer pain syndrome; neuromodulation; intrathecal pump; opioids; nerve blocks; joint injections
(This special issue belongs to the Section Medical Research)
Molecular Mechanisms and Therapeutic Effects of Drugs in Cancer—2nd Edition submission deadline 31 Aug 2026 | 4 articles | Viewed by 8941 | Submission Open
Keywords: cancer; therapy; cancer drug; molecular mechanism; signaling pathways; targeted therapy; in silico drug response studies; innovative cancer treatment
(This special issue belongs to the Section Medical Research)
Advances in Biomedical Frontier Technologies and Disease Diagnosis
edited by
submission deadline 31 Aug 2026 | 1 articles | Viewed by 3349 | Submission Open
Keywords: nanomedicine  ; biomaterials  ; gene therapy  ; drug delivery  ; bacteriotherapy  ; nanobiotechnology  ; hereditary diseases  ; bioinformatics  ; personalized medicine  ; smart biomaterials
(This special issue belongs to the Section Medical Research)
Postharvest Softening, Flavor and Quality of Fruits: Molecular Mechanisms and Regulatory Approaches
edited by Qinggang Zhu and Yaxiu Xu
submission deadline 31 Aug 2026 | 1 articles | Viewed by 1093 | Submission Open
Keywords: fruit softening; fruit quality; fruit flavor; molecular mechanisms; regulatory approaches
(This special issue belongs to the Section Plant Science)
Effects of Environmental Factors on Challenges of Plant Breeding: 2nd Edition submission deadline 31 Aug 2026 | 1 articles | Viewed by 566 | Submission Open
Keywords: plant breeding; winter hardiness; sowing time; adaptation to cold/frost; physiology of cold/frost tolerance; snow cover
(This special issue belongs to the Section Plant Science)
Innovations in Nuclear Medicine and Molecular Imaging submission deadline 31 Aug 2026 | Viewed by 102 | Submission Open
Keywords: nuclear medicine; molecular imaging; PET; SPECT; radiopharmaceuticals; theranostics; quantitative imaging; artificial intelligence; dosimetry; precision medicine
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Progress in Rehabilitation Interventions for Heart Failure
edited by , Jhonatan Betancourt-Peña, Iago Portela and Mauricio Hernández-Carrillo
submission deadline 31 Aug 2026 | Viewed by 90 | Submission Open
Keywords: heart failure; rehabilitation; exercise; interdisciplinary; telerehabilitation
(This special issue belongs to the Section Medical Research)
Molecular Pathways Shaping Head and Neck Cancer Care submission deadline 31 Aug 2026 | Viewed by 74 | Submission Open
Keywords: head and neck cancer; molecular pathways; tumor microenvironment; precision oncology; translational research
(This special issue belongs to the Section Medical Research)
The Biochemistry of Venoms: Exploring Molecular Diversity, Structural Mechanisms, and Their Biotechnological Uses
edited by and Ludovico Migliolo
submission deadline 31 Aug 2026 | Viewed by 46 | Submission Open
Keywords: biochemistry of venoms; venomics; diversity of toxins; mechanism of action; bioprospecting
(This special issue belongs to the Section Pharmaceutical Science)
Research Advances in Wetland Ecology
edited by and
submission deadline 31 Aug 2026 | Viewed by 46 | Submission Open
Keywords: wetland; restoration; function; plant; algae; lake eutrophication; interspecific relationship; biogeochemical cycling; climate change
(This special issue belongs to the Section Diversity and Ecology)
Cellular and Molecular Biology Behind Human Cognition
edited by Simone Battaglia and Masaru Tanaka
submission deadline 31 Aug 2026 | Viewed by 38 | Submission Open
Keywords: cognitive biology; synaptic and cellular plasticity; non-invasive brain stimulation techniques; synaptic and circuit plasticity; cognitive resilience; biomarkers of cognitive function; neuroinflammation and neurodegeneration; translational neuroscience; neuroplasticity; precision medicine: biomarkers; neurochemical
(This special issue belongs to the Section Physiology and Pathology)
Diagnosis, Treatment and Prognosis of Head and Neck Disorders
edited by
submission deadline 31 Aug 2026 | Viewed by 35 | Submission Open
Keywords: head and neck disorders  ; head and neck cancer  ; otolaryngology  ; diagnostic imaging and endoscopy  ; targeted therapy and immunotherapy  ; biomarkers and molecular pathology  ; precision medicine  ; prognostic models and outcomes  ; translational research
(This special issue belongs to the Section Medical Research)
Intensive Care Medicine: Current Concepts and Future Perspectives
edited by Shinichi Watanabe
submission deadline 31 Aug 2026 | Viewed by 29 | Submission Open
Keywords: intensive care; early mobilization; sepsis; mechanical ventilation; rehabilitation; artificial intelligence; PICS; multidisciplinary collaboration
(This special issue belongs to the Section Medical Research)
Chronic Kidney Diseases: Epidemiology, Diagnosis, and Treatment
edited by Stefanos K. Roumeliotis
submission deadline 31 Aug 2026 | Viewed by 28 | Submission Open
Keywords: chronic kidney disease; end stage kidney disease; hemodialysis; peritoneal dialysis; mitochondria; oxidative stress; vascular calcification
(This special issue belongs to the Section Medical Research)
Vascular Disease: Etiologic, Diagnostic, Prognostic and Therapeutic Research—3rd Edition submission deadline 31 Aug 2026 | Viewed by 23 | Submission Open
Keywords: vascular diseases; etiology; diagnosis; prognosis; therapy
(This special issue belongs to the Section Medical Research)
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