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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Dive into Myopia

edited by

Chun-Fu Liu

submission deadline 19 Jun 2026 | 2 articles | Viewed by 1787 | Submission Open

Keywords: myopia; hyperopia; myopia control; axial length; axial length retardation; axial length elongation; myopia complications; refraction measurement; atropine; rebound effect; orthokeratology; missight; defocus incorporated multiple segments (DIMSs); highly aspherical lenslets (HALs); red light; repeated low-level red light (RLRL) therapy; enhance myopia control; customized myopia control; peripheral refraction; peripheral myopia; refractive surgery; PRK; LASIK; smile; contact lens; spectacles

(This special issue belongs to the Section Medical Research)

Advances in Knee Biomechanics—2nd Edition

edited by Jason Shearn

submission deadline 22 Jun 2026 | Viewed by 38 | Submission Open

Keywords: knee; tendon; ligament; injury; repair; healing; biomechanics; advanced techniques

(This special issue belongs to the Section Physiology and Pathology)

Reconstruction of Bone Defects

edited by

Jörg Eschweiler

and

Philipp Kobbe

submission deadline 23 Jun 2026 | 5 articles | Viewed by 7288 | Submission Open

Keywords: bone and fracture biomechanics; bone healing; critical size bone defects; fracture non-union; inflammation; joint arthroplasty and fracture osteosynthesis; implant designs; materials proprieties; patient selection; primary and revision settings

(This special issue belongs to the Section Medical Research)

Recent Advances in Vascular Biology and Chronic Kidney Disease (CKD)

edited by

Yongseek Park

submission deadline 26 Jun 2026 | 1 articles | Viewed by 5022 | Submission Open

Keywords: chronic kidney disease; vascular dysfunction; endothelial cells

(This special issue belongs to the Section Medical Research)

Feature Papers in Medical Research: 4th Edition

edited by

Christian Lehmann

submission deadline 26 Jun 2026 | Viewed by 244 | Submission Open

Keywords: dermatological research; cancer research; cardiovascular research; general medicine; gastroenterological research; hematological research; immunological research; infectious diseases research; metabolism and endocrinology; nervous system research; nursing; pediatrics; pulmonary research; psychiatric research; rehabilitation; renal and urinary research; reproductive research and women's health; rheumatological research; skeletal and muscular research; vision research

(This special issue belongs to the Section Medical Research)

Advanced Technologies and Clinical Practice of Cancer Radiotherapy

edited by

Marcin Balcerzyk

submission deadline 26 Jun 2026 | Viewed by 28 | Submission Open

Keywords: proton therapy; BNCT; in vivo dose verification in radiotherapy; accelerators for radiation therapy; simulation of radiotherapies

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Application of Mass Spectrometry-Based Multi-Omics in Biomedical Research

edited by

Young Ah Goo

submission deadline 26 Jun 2026 | Viewed by 15 | Submission Open

Keywords: mass spectrometry; multi-omics; proteomics; metabolomics; lipidomics; mass spectrometry imaging (MSI); biomarker discovery; translational research

(This special issue belongs to the Section Medical Research)

Innovations in Thoracic Medicine: Advancements and Challenges—2nd Edition

edited by Paolo Scanagatta

submission deadline 26 Jun 2026 | Viewed by 9 | Submission Open

Keywords: thoracic medicine; lung cancer; artificial intelligence (AI); minimally invasive intervention; thoracic anesthesia; clinical innovation; technological advances

(This special issue belongs to the Section Medical Research)

Recent Advances in Physiotherapy for Musculoskeletal

edited by

Miguel Ángel Rosety-Rodríguez

and

Jorge Góngora-Rodríguez

submission deadline 30 Jun 2026 | 6 articles | Viewed by 12033 | Submission Open

Keywords: musculoskeletal rehabilitation; emerging technologies; virtual reality; artificial intelligence; inflammatory genetics; physiotherapy; sports medicine; functional recovery

(This special issue belongs to the Section Physiology and Pathology)

The Emerging Role of Microbiota in Health and Diseases

edited by Edyta Juszczuk-Kubiak and Katarzyna Góralska

submission deadline 30 Jun 2026 | 6 articles | Viewed by 9180 | Submission Open

Keywords: microbiota; eubiosis; dysbiosis; microbiota– host interaction; microbiota– gut– brain axis; microbiome; bacteria– fungi interactions; microbiota modification; holobiont; cross-feeding; microbiota related diseases; microbiota functions

(This special issue belongs to the Section Microbiology)

Current Advances in Lung Cancer Diagnosis and Treatment

edited by

Hakyoung Kim

, Daesik Yang and

Zhiwei Hu

submission deadline 30 Jun 2026 | 4 articles | Viewed by 6933 | Submission Open

Keywords: lung cancer; underlying lung disease; radiotherapy; systemic therapy; survival outcomes; complication; biomarkers

(This special issue belongs to the Section Medical Research)

Update on Microalgae Metabolites

edited by

Eduardo Jacob-Lopes

and

Leila Queiroz Zepka

submission deadline 30 Jun 2026 | 2 articles | Viewed by 3123 | Submission Open

Keywords: biosynthesis; culture conditions; bioactive compounds; biological activity; biorefinery; proteins; peptides; antifreeze proteins; enzymes; carbohydrates; exocellular polysaccharides; carbohydrate-binding proteins; lipids; fatty acids; chlorophylls; carotenoids; phycobiliproteins; vitamins; minerals; trace elements; sterols; secondary metabolites; downstream processing; purification; safety; regulatory issues; clinical tests

(This special issue belongs to the Section Microbiology)

Latest Updates on Clinical Microbiology and Antimicrobial Resistant Infection

edited by Jun Sung Hong

submission deadline 30 Jun 2026 | 2 articles | Viewed by 2557 | Submission Open

Keywords: enterobacteriaceae; antimicrobial resistance; infection; health

(This special issue belongs to the Section Microbiology)

Microalgae and Their Biotechnological Potential

edited by

Fantao Kong

, Yi Xin and Yuanxue Liang

submission deadline 30 Jun 2026 | 1 articles | Viewed by 2512 | Submission Open

Keywords: microalgae; biofuels; bioproducts; lipid metabolism; synthetic biology; system engineering

(This special issue belongs to the Section Microbiology)

Musculoskeletal Imaging: Innovations in Diagnostics and Interventional Therapies

edited by

Paolo Spinnato

submission deadline 30 Jun 2026 | 2 articles | Viewed by 2488 | Submission Open

Keywords: magnetic resonance imaging; bone and bones; computed tomography; sarcoma; interventional radiology

(This special issue belongs to the Section Medical Research)

Pathological and Clinical Updates on Eye Diseases

edited by Pier Luigi Surico and

Rohan Bir Singh

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1812 | Submission Open

Keywords: ophthalmology; eye diseases; gene therapy; ocular surface; ocular immunology; cornea

(This special issue belongs to the Section Medical Research)

Advances in Livestock Breeding, Nutrition and Metabolism

edited by

Imran Khan

submission deadline 30 Jun 2026 | 2 articles | Viewed by 1680 | Submission Open

Keywords: genetic selection; livestock breeding; genome editing; animal nutrition; precision feeding; nutritional additives; feed conversion; metabolism; animal health; sustainability

(This special issue belongs to the Section Animal Science)

Research on Gastrointestinal Cancer and Nutritional Health

edited by

Irene Lidoriki

, Adam Mylonakis and Dimitrios Tsapralis

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1233 | Submission Open

Keywords: dietary patterns; gastrointestinal cancer; clinical nutrition; nutritional status; nutritional assessment; metabolism; gastric cancer; esophageal cancer; pancreatic cancer; colorectal cancer

(This special issue belongs to the Section Medical Research)

Channel Proteins and Transporters in Human Health and Disease

edited by

Giorgia Scarpellino

Giorgia Chinigò

and

Roberta De Zio

submission deadline 30 Jun 2026 | Viewed by 1047 | Submission Open

Keywords: channel proteins; transporters; ion channel

(This special issue belongs to the Section Proteins and Proteomics)

Neuroimaging and Integrative Analyses in Psychiatry and Addictive Disorders

edited by Arkadiusz Komorowski

submission deadline 30 Jun 2026 | Viewed by 338 | Submission Open

Keywords: psychiatry; neuroimaging; forensic psychiatry; fMRI; PET; EEG; addiction; substance use disorders (SUD); psychotherapy; treatment-resistant depression (TRD); attention deficit hyperactivity disorder (ADHD)

(This special issue belongs to the Section Physiology and Pathology)

New Advances in the Treatment and Assessment of Temporomandibular Joint Disorders

edited by

Łukasz Rafał Pałka

submission deadline 30 Jun 2026 | Viewed by 292 | Submission Open

Keywords: orofacial dysfunction; multifactorial etiology; advanced diagnostic technologies; biomechanical modeling of TMJ; novel imaging techniques; inflammatory and degenerative changes; interdisciplinary management; conservative therapy approaches; occlusal concepts; splint therapy design; physical therapy regimens; long-term implant treatment outcomes; personalized treatment strategies

(This special issue belongs to the Section Medical Research)

Autoimmune Disorders: From Pathophysiology to Therapeutics

edited by

Giulia Lanzolla

and Chiara Mura

submission deadline 30 Jun 2026 | Viewed by 258 | Submission Open

Keywords: autoimmunity; autoimmune diseases; polyglandular autoimmune syndromes; thyroid autoimmune disease; type 1 diabetes

(This special issue belongs to the Section Physiology and Pathology)

Advances in Bioorganic and Medicinal Chemistry

edited by Sahar Kandil

submission deadline 30 Jun 2026 | Viewed by 136 | Submission Open

Keywords: medicinal chemistry; drug discovery; biological chemistry; therapeutic targets; therapeutic agents; treatment of diseases; new therapeutic strategies

Perspectives on Nutrition and Livestock Health

edited by Liuting Wu, Yan Wang and

Felix Kwame Amevor

submission deadline 30 Jun 2026 | 1 articles | Viewed by 133 | Submission Open

Keywords: nutrition; animal health; animal reproductive; animal welfare; gut microbiome

(This special issue belongs to the Section Animal Science)

Post-Concussion Syndrome and Functional Neurological Disorder

edited by

Ioannis Asterios Mavroudis

submission deadline 30 Jun 2026 | Viewed by 131 | Submission Open

Keywords: post-concussion syndrome; functional neurological disorder; mild traumatic brain injury; cognitive dysfunction ; neuroimaging; biomarkers; neurorehabilitation

(This special issue belongs to the Section Medical Research)

Applications of Dermatoscopy in Skin Diseases: 2nd Edition

edited by

Paweł Pietkiewicz

Enzo Errichetti

and

Cristian Navarrete

submission deadline 30 Jun 2026 | Viewed by 110 | Submission Open

Keywords: melanoma; skin cancer; inflammoscopy; trichoscopy; ultraviolet reflectance dermatoscopy; skin of color; basal cell carcinoma; squamous cell carcinoma; nevus; digital dermoscopy

(This special issue belongs to the Section Medical Research)

Transplant Medicine: Updates and Current Challenges

edited by Phillipe Abreu

submission deadline 30 Jun 2026 | Viewed by 88 | Submission Open

Keywords: robotic transplantation; organ transplants; transplant oncology

(This special issue belongs to the Section Medical Research)

Sleep-Disordered Breathing: Key Pathophysiological Mechanisms and Their Clinical Implications

edited by

Jinkwan Kim

submission deadline 30 Jun 2026 | Viewed by 84 | Submission Open

Keywords: sleep-disordered breathing; sleep fragmentation; inflammation; cardiovascular disease; insulin resistance

(This special issue belongs to the Section Physiology and Pathology)

Vector-Borne Diseases and One Health

edited by

Jeronimo Alencar

, Shayenne Silva and

Michail Kotsyfakis

submission deadline 30 Jun 2026 | Viewed by 60 | Submission Open

Keywords: vector-borne diseases; One Health; malaria; dengue; Zika; chikungunya; yellow fever; West Nile virus; Lyme disease; leishmaniasis; Chagas

(This special issue belongs to the Section Animal Science)

Advances and Challenges in Urothelial and Prostate Cancer: Toward Precision Urologic Oncology

edited by Sashi S. Kommu

submission deadline 30 Jun 2026 | Viewed by 58 | Submission Open

Keywords: urothelial carcinoma; prostate cancer; immunotherapy; genomics and biomarkers; precision imaging (PSMA PET; mpMRI); targeted therapies (PARP; FGFR; DDR); focal therapy and theranostics; tumour microenvironment; quality of life and survivorship; health disparities in cancer care; artificial intelligence

(This special issue belongs to the Section Medical Research)

“Out-of-the-Organics-Box” Reflections On and Scenarios for Life’s Emergence

edited by

Wolfgang Nitschke

submission deadline 30 Jun 2026 | Viewed by 49 | Submission Open

Keywords: emergence of life; thermodynamics; bioenergetics; information theory; early metabolism; metal ions in biochemistry

(This special issue belongs to the Section Origin of Life)

Mechanisms and Modulation of Pain: From Ion Channels to Translational Therapeutics

edited by Álvaro Yogi

submission deadline 30 Jun 2026 | Viewed by 48 | Submission Open

Keywords: pain; mechanisms; signaling pathways; ion channels; therapeutic targets; neuropathic pain; inflammatory pain; pre-clinical models

(This special issue belongs to the Section Pharmaceutical Science)

Neural Mechanisms of Brain–Computer Interfaces

edited by

Miguel Pais-Vieira

submission deadline 30 Jun 2026 | Viewed by 48 | Submission Open

Keywords: brain– machine interfaces; neurophysiology; somatosensory cortex; motor cortex

(This special issue belongs to the Section Physiology and Pathology)

Physical Rehabilitation for Musculoskeletal Disorders: 2nd Edition

edited by

You Gyoung Yi

submission deadline 30 Jun 2026 | Viewed by 45 | Submission Open

Keywords: physical rehabilitation; musculoskeletal disorders; pain management; range of motion; muscle strengthening; mobility enhancement; physical therapy; manual therapy; AI in rehabilitation

(This special issue belongs to the Section Medical Research)

Cranial Base Tumors: Pathogenesis, Diagnosis, and Treatment

edited by

Andrew J. Fishman

and Marcin Szymański

submission deadline 30 Jun 2026 | Viewed by 40 | Submission Open

Keywords: skull base tumors; neuro-oncology; endoscopic surgery; cranial nerve preservation; AI-assisted diagnostics; multidisciplinary management

(This special issue belongs to the Section Medical Research)

Comprehensive Treatment and Precision Medicine Strategies for Heart Disease

edited by Serge Sicouri

submission deadline 30 Jun 2026 | Viewed by 28 | Submission Open

Keywords: precision medicine; artificial intelligence; risk stratification; machine learning; translational research; cardiovascular outcomes

(This special issue belongs to the Section Medical Research)

Extracellular Vesicles: Biology, Mechanisms, and Therapies for Cerebrovascular Disorders

edited by Jinju Wang

submission deadline 30 Jun 2026 | Viewed by 20 | Submission Open

Keywords: extracellular vesicles; cerebrovascular disorders; dementia; extracellular vesicle-based therapy

(This special issue belongs to the Section Physiology and Pathology)

Rewiring Bacterial Communication: Extracellular Vesicles and Microbial Signals Across Host Interfaces

edited by Sara Carloni

submission deadline 30 Jun 2026 | Viewed by 19 | Submission Open

Keywords: bacterial extracellular vesicles (bEVs); host– microbe communication; microbiota dynamics; immune modulation; translational applications

(This special issue belongs to the Section Microbiology)

Drug Safety and Outcomes in Respiratory and Critical Care Medicine

edited by Josef Yayan

submission deadline 30 Jun 2026 | Viewed by 15 | Submission Open

Keywords: drug safety; adverse drug reactions; pharmacovigilance; critical care medicine; respiratory diseases; clinical outcomes; intensive care pharmacotherapy; drug– drug interactions

(This special issue belongs to the Section Pharmaceutical Science)

New Insights into Diagnosis and Therapeutic Strategies for Chronic Liver Diseases

edited by

Cristina Marginean

submission deadline 20 Jul 2026 | 4 articles | Viewed by 7259 | Submission Open

Keywords: chronic liver disease; metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic dysfunction-associated steatohepatitis (MASH); drug-induced liver injury (DILI); hepatocellular carcinoma; biomarkers of liver fibrosis; imaging of liver fibrosis; CEUS; novel therapeutic strategies for CLDs

(This special issue belongs to the Section Medical Research)

Herbal Extracts in Skin Health and Disease

edited by

Josipa Bukić

submission deadline 20 Jul 2026 | Viewed by 113 | Submission Open

Keywords: herbal extracts; natural products; skin disorders; skin care

(This special issue belongs to the Section Pharmaceutical Science)

Emerging Knowledge on Human Immunodeficiency Virus

edited by

Giota Lourida

and

Dimitrios Paraskevis

submission deadline 22 Jul 2026 | 2 articles | Viewed by 17528 | Submission Open

Keywords: HIV; antiretroviral treatment; long-acting ART; pre-exposure prophylaxis; HIV surveillance; antiretroviral resistance; primary resistance; HIV epidemiology; special populations; cascade of care; HIV diagnosis

(This special issue belongs to the Section Medical Research)

Contemporary Therapeutic Strategies for Solid Tumors

edited by Chohao Lee

submission deadline 26 Jul 2026 | Viewed by 36 | Submission Open

Keywords: therapeutic strategies; survival analysis; solid tumors; cancer treatment; targeted therapy; immunotherapy; precision medicine; clinical outcomes; prognostic factors

(This special issue belongs to the Section Medical Research)

Promising Therapeutic Horizons for Regenerative Medicine in Animals

edited by

Hussein M. El-Husseiny

and

Sharun Khan

submission deadline 28 Jul 2026 | Viewed by 225 | Submission Open

Keywords: stem cells; induced pluripotent stem cells (iPSCs); soft tissue engineering; in vivo and in vitro investigations; extracellular vesicles; preclinical studies; clinical studies; platelet-rich plasma; platelet-rich fibrin; cell-based therapy; cell-free therapy; orthopedics; cardiology

(This special issue belongs to the Section Animal Science)

Advances in Fetal Medicine: From Prenatal Diagnosis to Fetal and Neonatal Therapy

edited by Przemysław Kosinski

submission deadline 30 Jul 2026 | Viewed by 912 | Submission Open

Keywords: fetal medicine; prenatal diagnosis; non-invasive prenatal testing (NIPT); fetal imaging; fetal therapy; fetal surgery; neonatal intensive care; genetic and genomic advances; perinatal outcomes; maternal-fetal health

(This special issue belongs to the Section Reproductive and Developmental Biology)

Therapeutic Effects of Natural Products on Human Diseases—3rd Edition

edited by

Seung Ho Lee

submission deadline 30 Jul 2026 | Viewed by 26 | Submission Open

Keywords: natural products; natural extracts; cancer; neurodegenerative diseases; immunological disorders; metabolic diseases; oriental medicine; microorganisms; algae; functional foods

(This special issue belongs to the Section Pharmaceutical Science)

Treatment and Prognosis of Thoracic Diseases

edited by

Alessandro Gonfiotti

and

Alice Ravasin

submission deadline 30 Jul 2026 | Viewed by 14 | Submission Open

Keywords: thoracic malignancies; lung cancer management ; targeted therapy ; immunotherapy ; molecular diagnostics ; multidisciplinary care ; personalized treatment

(This special issue belongs to the Section Medical Research)

Microorganisms Engineering and Gene-Editing Methods

edited by

Jichao Wang

Guang Zhao

and Xia Zhao

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1281 | Submission Open

Keywords: microorganisms engineering; metabolic engineering; strain optimization; gene editing; CRISPR; recombination

(This special issue belongs to the Section Genetics and Genomics)

Innovation in Fish Nutrition, Production Technology, and Welfare

edited by

Marian Burducea

, Liviu-Dan Miron and

Cristian-Alin Barbacariu

submission deadline 31 Jul 2026 | Viewed by 430 | Submission Open

Keywords: aquaculture; fish nutrition; fish welfare; water quality; fish disease; feed additives; rearing systems; modern feeding technologies; waste management

Skin Care and Innovation from the Perspective of Molecular Dermatology

edited by