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Life
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Innovations in Nuclear Medicine and Molecular Imaging
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Innovations in Nuclear Medicine and Molecular Imaging

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Radiobiology and Nuclear Medicine".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 815

Special Issue Editors

Dr. Christian Kühnel

E-Mail Website
Guest Editor
Clinic of Nuclear Medicine, Jena University Hospital, D-07749 Jena, Germany
Interests: nuclear medicine; molecular imaging; PET; SPECT; radiopharmaceuticals; hybrid imaging; quantitative imaging; dosimetry; theranostics; radiation protection; medical physics; preclinical research
Prof. Dr. Yiannis Parpottas

E-Mail Website
Guest Editor
Department of Mechanical Engineering, Frederick University, Nicosia 1036, Cyprus
Interests: nuclear medicine imaging; PET; SPECT; hybrid imaging; quantitative imaging; dosimetry; radiation protection; medical physics

Special Issue Information

Dear Colleagues,

This Special Issue, titled "Innovations in Nuclear Medicine and Molecular Imaging", focuses on the latest advances, applications, and translational developments in the field of nuclear medicine. It aims to highlight novel diagnostic and therapeutic strategies that integrate molecular imaging techniques such as PET, SPECT, hybrid modalities (PET/CT, SPECT/CT, PET/MRI), and emerging radiopharmaceutical approaches.

I invite you for original research articles and comprehensive reviews addressing technological innovations, image quantification methods, artificial intelligence applications, radiopharmaceutical development, and clinical implementation studies. Contributions that explore theranostics, personalized dosimetry, or the translation of molecular imaging biomarkers from preclinical research to clinical practice.

The goal is to bring together cutting-edge research that advances the diagnostic and therapeutic impact of nuclear medicine. We particularly encourage interdisciplinary contributions that bridge the gap between physics, chemistry, and clinical application to improve precision medicine.

Dr. Christian Kühnel
Prof. Dr. Yiannis Parpottas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nuclear medicine
  • molecular imaging
  • PET
  • SPECT
  • radiopharmaceuticals
  • theranostics
  • quantitative imaging
  • artificial intelligence
  • dosimetry
  • precision medicine

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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12 pages, 1871 KB  
Article
Quantification of Isoflurane Uptake for Immobilization of Ostrich Embryos for Preclinical In Ovo Imaging
by Thomas Winkens, Wiebke Neuschulz, Hans-Wolfgang Hoppe, Olga Perkas, Philipp Seifert, Falk Gühne, Julia Greiser, Martin Freesmeyer and Christian Kühnel
Life 2026, 16(3), 525; https://doi.org/10.3390/life16030525 - 22 Mar 2026
Viewed by 429
Abstract
Preclinical imaging has recently been expanded through the use of ostrich embryos as an alternative in vivo model. In ovo experiments represent a promising substitute for conventional rodent-based animal testing. For artifact-free dynamic nuclear medicine imaging, reliable immobilization of embryos is essential. Although [...] Read more.
Preclinical imaging has recently been expanded through the use of ostrich embryos as an alternative in vivo model. In ovo experiments represent a promising substitute for conventional rodent-based animal testing. For artifact-free dynamic nuclear medicine imaging, reliable immobilization of embryos is essential. Although previous studies have demonstrated the feasibility of isoflurane anesthesia, the kinetics and uptake mechanisms of isoflurane in ostrich embryos remain insufficiently characterized. The aim of this study was to characterize gas exchange dynamics in ostrich eggs and to quantify isoflurane uptake using two complementary approaches: indirect consumption measurements in a closed system and direct quantification by serial blood sampling. Fourteen ostrich eggs, including seven fertilized and seven unfertilized specimens, were analyzed at developmental stages up to day 37 of incubation. Gas exchange was assessed in a sealed container using a clinical anesthesia gas monitoring system to measure oxygen consumption and carbon dioxide excretion. Isoflurane uptake was evaluated during exposure to concentrations of 2%, 4%, or 6%. In a separate experimental series, serial blood samples were collected during and after exposure to the same concentrations to determine systemic uptake. Fertilized embryos showed progressive increases in metabolic activity, with a maximal oxygen consumption and carbon dioxide excretion of 116 mL/h/kg and 93 mL/h/kg on day 37. Indirect measurements demonstrated isoflurane uptake rates of up to 1.1 mL/min at 6%, with proportionally lower values at 4% and 2%. Blood analyses confirmed systemic absorption, peak concentrations of 160 µg/mL, and detectable residual levels for up to 120 min after exposure. These findings refine in ovo imaging. Full article
(This article belongs to the Special Issue Innovations in Nuclear Medicine and Molecular Imaging)
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