Vascular Disease: Etiologic, Diagnostic, Prognostic and Therapeutic Research—3rd Edition

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 691

Special Issue Editors


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Guest Editor
Medical Clinic Number 1, Internal Medicine Department, Iuliu Hatieganu University of Medicine and Pharmacy, 400000 Cluj-Napoca, Romania
Interests: intracoronary imaging; mainly OCT; acute coronary syndromes; primary PCI
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Internal Medicine, Metabolic Diseases and Angiology, Medical University of Silesia, Ziolowa St. 45/47, 40-635 Katowice, Poland
Interests: physical medicine; thermal imaging; cryotherapy; cryogenic temperatures; vascular medicine; oxidative stress; rehabilitation; internal medicine
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Special Issue Information

Dear Colleagues,

The Guest Editors are grateful to the many researchers who contributed to the success of the previous volumes of this Special Issue:

Volume 1: https://www.mdpi.com/journal/life/special_issues/vascular_etiology_diagnosis_threapy_prognosis
Volume 2: https://www.mdpi.com/journal/life/special_issues/0F2FI8OOW5

We are very pleased to now announce the third volume of our Special Issue.

Vascular diseases have an increasing morbidity and mortality impact, as they are related to population aging, socio-economic factors or increasing prevalence of risk factors, such as diabetes. The ongoing COVID-19 pandemic has led to vascular complications, both at the arterial and venous sites. Vascular medicine is not just a field of intense medical research, having also become a distinct medical specialty or subspecialty in many countries. Vascular diseases involve peripheral arteries and veins, aorta and visceral abdominal vessels and cervical vessels, such as the carotid and vertebral arteries. Cardiac and cerebral complications are often related to vascular diseases. Coronary, carotid and peripheral arteries have common atherothrombotic etiology and share many clinical diagnostic, prognostic and therapeutic relationships. Microcirculation is a field of increasing fundamental and clinical research interest, both for arterial and venous diseases. The research field in vascular diseases and medicine is broad and open to contributions from fundamental (genetics, hemostasis, biochemistry, etc.) and clinical medicine. Diagnosis and therapy of vascular diseases are performed by medical, surgical and interventional procedures and specialists. The scope of this Special Issue covers specific arterial and venous diseases, their specific impact on organ diseases and the relationships between vascular diseases at multiple sites. New drugs are developed to control risk factors (dyslipidemia, hypertension, diabetes, etc.) or for antiplatelet and anticoagulant therapy, with a significantly beneficial prognostic impact. Surgical revascularization at different arterial sites improves morbidity and mortality. Interventional procedures gain ground on both arterial and venous sites and have been proven safe and effective. The aim of this Special Issue is to offer an overview of the richness of vascular fundamental and clinical medicine, covering all aspects of etiologic, diagnostic, prognostic and therapeutic research.

Dr. Dan Mircea Olinic
Prof. Dr. Agata Stanek
Guest Editors

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Keywords

  • vascular diseases
  • etiology
  • diagnosis
  • prognosis
  • therapy

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Published Papers (1 paper)

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Research

17 pages, 1256 KB  
Article
Clinical Efficacy and Biomechanical Behavior of Different Compression Systems in Venous Ulcers: Pressure, Stiffness and Healing
by Juan Francisco Jiménez García, Maria Piedad García Ruiz, Francisco González Jiménez, Maria Gutierrez García, Jose Luis Jiménez Laínez, Mercedes Muñoz Condez, Ana Belen Fernández Ramirez and Francisco Pedro García Fernández
Life 2026, 16(4), 585; https://doi.org/10.3390/life16040585 - 1 Apr 2026
Viewed by 445
Abstract
Introduction: Venous leg ulcers are the most severe manifestation of chronic venous insufficiency, and their treatment is based on compression therapy, whose effectiveness depends on the magnitude of the pressure and the biomechanical properties of the system. Doubts persist about the actual correlation [...] Read more.
Introduction: Venous leg ulcers are the most severe manifestation of chronic venous insufficiency, and their treatment is based on compression therapy, whose effectiveness depends on the magnitude of the pressure and the biomechanical properties of the system. Doubts persist about the actual correlation between interface pressure, bandage stiffness and clinical outcomes in real-world practice. Objective: To compare the clinical efficacy and biomechanical behavior of different multicomponent compression systems in venous leg ulcers, analyzing the relationship between interface pressure, static stiffness, edema reduction and variation in the wound area. Methodology: This is a prospective, observational and multicenter study in six districts/health areas of Andalusia, in adults with active venous ulcers attended by Advanced Practice Nurses in Complex Chronic Wounds. Several multi-component compression systems were applied, and interface pressure was monitored using Tight Alright® at three points on the leg for 96 h, recording final pressure, static stiffness, perimeters and ulcer area. Results: All systems achieved a reduction in leg circumference, more marked at the proximal points, evidencing an overall decongestant effect. The correlation between final pressure and edema reduction was weak, and relevant differences were observed in the reduction in ulcer area, with Urgo K2 and CPK Compress 2 standing out with decreases of more than 50% compared to medium or low yields of other systems with comparable pressures. The static stiffness analysis showed specific patterns according to system and leg size, as well as a heterogeneous longitudinal distribution of pressure. Conclusions: The efficacy of compression in venous ulcers depends on both the interface pressure and the design and biomechanical behavior of the system, with clinically relevant differences between multicomponent dressings. Multipoint pressure and stiffness monitoring provides useful information to optimize system selection and support decisions based on biomechanical parameters and standardized clinical outcomes. Full article
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