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Life
Special Issues
Chronic Kidney Diseases: Epidemiology, Diagnosis, and Treatment
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Chronic Kidney Diseases: Epidemiology, Diagnosis, and Treatment

A Special Issue of Life (ISSN 2075-1729) belonging to the section "Medical Research".

Deadline for manuscript submissions: 31 May 2027 | Viewed by 1242

Editor

Dr. Stefanos Roumeliotis

E-Mail Website
Guest Editor
2nd Department of Nephrology, Medical School, AHEPA Hospital, Aristotle University, 54636 Thessaloniki, Greece
Interests: CKD; hemodialysis; oxidative stress; vitamin K; diabetic nephropathy; vascular calcification; CVD; matrix GLA protein
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, it has become evident that oxidative stress is interrelated with vascular calcification and inflammation in chronic kidney disease patients and predisposes such individuals to cardiovascular disease and deterioration of kidney function. In this Special Issue, we aim to attract both reviews and original studies, investigating the possible roles of oxidative stress and/or vascular calcification in chronic kidney disease and end stage kidney disease patients.

Dr. Stefanos Roumeliotis
Guest Editor

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Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chronic kidney disease
  • end stage kidney disease
  • hemodialysis
  • peritoneal dialysis
  • mitochondria
  • oxidative stress
  • vascular calcification

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Published Papers (2 papers)

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Research

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13 pages, 545 KB  
Article
Exploratory Analysis of Pruritus and Sleep Outcomes After LCR35 Supplementation in Maintenance Hemodialysis: A Randomized, Open-Label Controlled Study
by Kuo-Chin Hung, Min-Tser Liao, Cai-Mei Zheng, Shih-Feng Chen, Li-Ting Lu, Chia-Ter Chao and Kuo-Cheng Lu
Life 2026, 16(8), 1291; https://doi.org/10.3390/life16081291 - 5 Aug 2026
Viewed by 354
Abstract
Background/Objectives: Uremic pruritus and sleep disturbance commonly coexist in patients receiving maintenance hemodialysis. This analysis examined whether supplementation with Lactobacillus casei var. rhamnosus LCR35 was associated with changes in pruritus and sleep outcomes. Methods: This 12-week randomized, open-label, controlled study included 78 patients [...] Read more.
Background/Objectives: Uremic pruritus and sleep disturbance commonly coexist in patients receiving maintenance hemodialysis. This analysis examined whether supplementation with Lactobacillus casei var. rhamnosus LCR35 was associated with changes in pruritus and sleep outcomes. Methods: This 12-week randomized, open-label, controlled study included 78 patients receiving maintenance hemodialysis who were assigned to LCR35 supplementation (n = 38; three sachets daily) or usual care without probiotic supplementation (n = 40). No placebo was used. Outcomes were Pittsburgh Sleep Quality Index (PSQI) and 5-D Itch Scale results. We used analysis of covariance (ANCOVA) for between-group analyses, with the week-12 score as the dependent variable and the corresponding baseline score as a covariate. Results: In the LCR35 group, descriptive improvements were observed in the 5-D Itch Scale and selected PSQI outcomes. However, none of the baseline-adjusted between-group differences was statistically significant: for 5-D Itch Scale, −1.48 (95% confidence interval (CI), −3.64 to 0.68; p = 0.176); for global PSQI, −0.80 (95% CI, −2.09 to 0.50; p = 0.225); for PSQI sleep disturbance, −0.07 (95% CI, −0.27 to 0.13; p = 0.482); and use of sleep medications, −0.28 (95% CI, −0.67 to 0.12; p = 0.163). In the LCR35 group, the exploratory association between changes in pruritus and the PSQI sleep-disturbances component was significant before, but not after, false-discovery-rate (FDR) correction (p = 0.007; FDR q = 0.055). Conclusions: Our preliminary findings raised the possibility that LCR35 might modestly influence pruritus and specific sleep disturbances. However, our results do not firmly establish a treatment effect, nor a patient phenotype most likely to benefit. Full article
(This article belongs to the Special Issue Chronic Kidney Diseases: Epidemiology, Diagnosis, and Treatment)
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Other

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19 pages, 4834 KB  
Systematic Review
Dose–Response Effects of Different Exercise Modalities on Blood Pressure Control in Patients with Chronic Kidney Disease: A Systematic Review and Network Meta-Analysis
by Dongze Li, Kaiming Chen, Shibo Kong, Zhengyu Gou, Xinmiao Feng and Jiezhong Wu
Life 2026, 16(8), 1243; https://doi.org/10.3390/life16081243 - 27 Jul 2026
Viewed by 428
Abstract
Background: Uncertainty persists regarding the dose–response association between exercise exposure and blood pressure (BP) control in chronic kidney disease (CKD). This dose–response network meta-analysis examined whether different exercise modalities and model-estimated metabolic-equivalent exposure levels were associated with changes in systolic BP (SBP) and [...] Read more.
Background: Uncertainty persists regarding the dose–response association between exercise exposure and blood pressure (BP) control in chronic kidney disease (CKD). This dose–response network meta-analysis examined whether different exercise modalities and model-estimated metabolic-equivalent exposure levels were associated with changes in systolic BP (SBP) and diastolic BP (DBP). Methods: Exercise dose was estimated as metabolic equivalents of task minutes per week (MET-min/week) from reported session duration, frequency, and intensity. Primary outcomes were changes in SBP and DBP, with exploratory subgroup analyses by dialysis status, baseline BP, and intervention duration. Results: The analysis included 26 randomized controlled trials (1218 participants). Aerobic exercise was associated with lower SBP, with the greatest model-estimated reduction at 880 MET-min/week (MD, −7.73 mm Hg). Resistance and mind–body exercise also showed model-estimated reductions, whereas combined aerobic-resistance training was not statistically significant. Dose–response estimates differed by dialysis status and intervention length, but several subgroup estimates were based on sparse data and wide uncertainty. Evidence certainty ranged from very low to high (CINeMA). Conclusions: Exercise interventions may be associated with BP reduction in CKD, but the identified MET-min/week ranges should be interpreted as exploratory, model-derived estimates rather than validated therapeutic thresholds. Better reported randomized trials are needed to confirm dose ranges, safety, adherence, and tolerability in dialysis and non-dialysis CKD populations. Full article
(This article belongs to the Special Issue Chronic Kidney Diseases: Epidemiology, Diagnosis, and Treatment)
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