Intensive Care Medicine: Current Concepts and Future Perspectives

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 2881

Special Issue Editor


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Guest Editor
Department of Physical Therapy, Faculty of Rehabilitation, Gifu University of Health Science, 2-92 Hi-gashiuzura, Gifu 500-8281, Japan
Interests: critically ill patients; sepsis; sarcopenia; physical therapy; early mobilization; early rehabilitation

Special Issue Information

Dear Colleagues,

This Special Issue, titled “Intensive Care Medicine: Current Concepts and Future Perspectives”, aims to explore contemporary advances and future directions in the multidisciplinary field of intensive care medicine. Critically ill patients often face complex physiological, metabolic, and functional challenges that require integrated and evidence-based approaches for optimal outcomes. This issue seeks to highlight novel strategies, technologies, and clinical frameworks that improve survival, recovery, and long-term quality of life after critical illness.

Recent progress in early rehabilitation, mechanical ventilation management, sepsis care, extracorporeal therapies, and artificial intelligence-driven monitoring has transformed the landscape of critical care. Moreover, the COVID-19 pandemic accelerated innovation in tele-intensive care, interprofessional collaboration, and data-driven decision-making. By bringing together international perspectives from clinicians, researchers, and educators, this Special Issue aims to clarify best practices and illuminate pathways for personalized and sustainable critical care delivery.

We welcome original research, reviews, clinical trials, and case-based studies focusing on intensive care physiology, treatment protocols, rehabilitation, and outcome prediction.

Topics of interest include (but are not limited to) the following:

  • Early mobilization and rehabilitation in the ICU;
  • Sepsis and organ dysfunction management;
  • Mechanical ventilation and weaning strategies;
  • Nutritional and metabolic support in critical illness;
  • Long-term outcomes and post-intensive care syndrome (PICS);
  • Technological innovations: AI, machine learning, and digital health in ICU.

By integrating current concepts with emerging evidence, this Special Issue aims to contribute to the evolution of intensive care medicine and inspire the next generation of clinical and research innovations.

Dr. Shinichi Watanabe
Guest Editor

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • intensive care
  • early mobilization
  • sepsis
  • mechanical ventilation
  • rehabilitation
  • artificial intelligence
  • PICS
  • multidisciplinary collaboration

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Published Papers (2 papers)

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Research

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10 pages, 540 KB  
Article
Association Between Time to First Mobilization and Recovery of Oral Intake Function in Patients with Pneumonia: A Two-Center Retrospective Cohort Study
by Shinichi Watanabe, Takaaki Sakurai, Takahiro Kanaya, Takumi Iwasaki, Hyosuke Oshima, Tetsuya Furukawa, Tomohiro Yoshikawa, Seichi Nakahashi and Yasunari Morita
Life 2026, 16(4), 691; https://doi.org/10.3390/life16040691 - 20 Apr 2026
Viewed by 380
Abstract
Delayed recovery of oral intake is common in hospitalized patients with pneumonia, particularly among older adults with reduced physical activity. Despite the recent emphasis on early mobilization, the relationship between the timing of first mobilization and recovery of oral intake function remains unclear. [...] Read more.
Delayed recovery of oral intake is common in hospitalized patients with pneumonia, particularly among older adults with reduced physical activity. Despite the recent emphasis on early mobilization, the relationship between the timing of first mobilization and recovery of oral intake function remains unclear. Thus, this retrospective cohort study investigated the association between time to first mobilization and recovery of oral intake in patients hospitalized with pneumonia. We analyzed 431 admitted patients with pneumonia, including aspiration pneumonia and coronavirus disease 2019 pneumonia, at two institutions. The Functional Oral Intake Scale ≥ 4 (partial oral intake recovery) was designated as the primary outcome. The main exposure was the number of days from admission to first mobilization. Multivariable Cox proportional hazards models were used after appropriate adjustments. The median time to first mobilization was 4 days (IQR: 2–14 days). Longer time to first mobilization was significantly associated with delayed recovery of oral intake (HR: 0.96, 95% CI: 0.94–0.98, p < 0.001). Thus, early mobilization may promote the recovery of oral intake in patients with pneumonia. These findings suggest that avoiding excessive delays in mobilization may support the recovery of oral intake and swallowing function in hospitalized patients with pneumonia. Full article
(This article belongs to the Special Issue Intensive Care Medicine: Current Concepts and Future Perspectives)
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Review

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22 pages, 3191 KB  
Review
Airway Management in the ICU and Emergency Department in Resource-Limited Settings
by Sahil Kataria, Deven Juneja, Ravi Jain, Tonny Veenith and Prashant Nasa
Life 2026, 16(2), 195; https://doi.org/10.3390/life16020195 - 23 Jan 2026
Cited by 1 | Viewed by 2202
Abstract
Airway management is central to the care of critically ill patients, yet it remains one of the most challenging interventions in emergency departments and intensive care units. Patients often present with severe physiological instability, limited cardiopulmonary reserve, and high acuity, while clinicians often [...] Read more.
Airway management is central to the care of critically ill patients, yet it remains one of the most challenging interventions in emergency departments and intensive care units. Patients often present with severe physiological instability, limited cardiopulmonary reserve, and high acuity, while clinicians often work under constraints related to time for preparation, equipment availability, trained workforce, monitoring, and access to advanced rescue techniques. These challenges are particularly pronounced in low- and middle-income countries and other resource-limited or austere environments, where the margin for error is narrow and delays or repeated attempts in airway management may rapidly precipitate hypoxemia, hemodynamic collapse, or cardiac arrest. Although contemporary airway guidelines emphasize structured preparation and rescue pathways, many assume resources that are not consistently available in such settings. This narrative review discusses pragmatic, context-adapted strategies for airway management in constrained environments, with emphasis on physiology-first preparation, appropriate oxygenation and induction techniques, simplified rapid-sequence intubation, and the judicious use of basic airway adjuncts, supraglottic devices, and video laryngoscopy, where available. Adapted difficult airway algorithms, front-of-neck access in the absence of surgical backup, human factors, team training, and ethical considerations are also addressed. This review aims to support safer and effective airway management for critically ill patients in resource-limited emergency and intensive care settings. Full article
(This article belongs to the Special Issue Intensive Care Medicine: Current Concepts and Future Perspectives)
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