Diagnosis, Treatment and Prognosis of Head and Neck Disorders

Dear Colleagues,

Disorders of the head and neck region represent a highly diverse and clinically complex group of diseases, encompassing inflammatory conditions, benign and malignant tumors, functional disorders, and traumatic or iatrogenic injuries. The head and neck region plays essential roles in respiration, phonation, mastication, swallowing, olfaction, and aesthetics; thus, diseases affecting this anatomical area may have profound impacts on patients' quality of life, psychological well-being, and long-term prognosis.

Recent advances in diagnostic technology—including high-resolution endoscopy, radiologic imaging, molecular pathology, and artificial intelligence-based analysis—have significantly improved early detection and diagnostic accuracy. Meanwhile, therapeutic strategies have rapidly evolved, incorporating precision radiotherapy, targeted therapy, immunotherapy, and novel pharmacological interventions. Despite these advances, challenges remain in optimizing individualized treatment strategies, predicting disease progression, and improving long-term functional and oncological outcomes.

This Special Issue aims to provide an up-to-date overview of research on the diagnosis, treatment, and prognosis of head and neck disorders by integrating clinical, translational, and technological perspectives. We welcome original research articles, reviews, and case-based studies that explore innovative diagnostic tools, emerging therapeutic modalities, prognostic biomarkers, rehabilitation strategies, and long-term outcome analyses.

Topics of interest include, but are not limited to, the following:

• Advanced diagnostic approaches and imaging technologies;
• Molecular and immunological mechanisms underlying head and neck disorders;
• Medical and radiation-based therapies, including targeted and immunotherapies;
• Prognostic factors and predictive models;
• Functional outcomes, quality of life, and rehabilitation;
• Artificial intelligence and digital health applications in head and neck care;
• Prevention, early detection, and screening strategies.

By bringing together multidisciplinary insights from clinicians, researchers, and biomedical engineers, this Special Issue aims to foster academic exchange and inspire future research directions in the rapidly evolving field of head and neck medicine. Ultimately, our goal is to improve diagnostic accuracy, optimize treatment outcomes, and enhance patient-centered care.

Dr. Geng-He Chang
Guest Editor

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