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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Etiology, Prediction and Prognosis of Ischemic Stroke

edited by

Vida Abedi

Ramin Zand

and Jiang Li

submission deadline 31 Jan 2026 | 3 articles | Viewed by 9041 | Submission Open

Keywords: ischemic stroke; recurrent stroke; etiology; machine learning; artificial intelligence; subtyping; prediction; prognosis; genetic risk factors; lifestyle factors; environmental factors; biomarkers; cerebrovascular diseases; prevention; treatment strategies

(This special issue belongs to the Section Physiology and Pathology)

Common and Novel Markers of Inflammation and Tissue Damage in Various Pathological Conditions—2nd Edition

edited by

Marzena Tylicka

Joanna Kamińska

and

Olga Koper-Lenkiewicz

submission deadline 31 Jan 2026 | 4 articles | Viewed by 5261 | Submission Open

Keywords: body fluids; cytokines; damage-associated molecular patterns (DAMPs); inflammatory response; injury; markers of inflammation and tissue damage; metalloproteinases; novel markers; pathological conditions; proteasome; tissue damage; tissue repair processes; various diseases

(This special issue belongs to the Section Physiology and Pathology)

Microbiome–Gut–Brain Connections: New Windows into Health and Disease

edited by

Yating Wan

and Qi Su

submission deadline 31 Jan 2026 | 3 articles | Viewed by 4853 | Submission Open

Keywords: gut microbes; gut– brain axis; neuroscience

(This special issue belongs to the Section Microbiology)

Prevention, Diagnosis, and Treatment of Gestational Diseases

edited by

Andrea Suranyi

submission deadline 31 Jan 2026 | 4 articles | Viewed by 3899 | Submission Open

Keywords: gestational diseases; gestational diabetes; preeclampsia; pregnancy complications

(This special issue belongs to the Section Medical Research)

Natural Products and Modern Drug Discovery: Emerging Strategies Targeting Cancer- and Disease-Related Molecular Mechanisms

edited by

Chia-Jui Weng

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2729 | Submission Open

Keywords: natural products; phytochemicals; drug discovery; bioactivity profiling; pharmacophore modeling; synthetic biology; cancer therapy; microbial metabolites

(This special issue belongs to the Section Medical Research)

Recent Advances in Valve Therapy: Clinical and Molecular Perspectives

edited by

Panayotis Vlachakis

, Konstantinos Toutouzas and Constantina Aggeli

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2695 | Submission Open

Keywords: transcatheter aortic valve implantation (TAVI); valve-in-valve; long-term outcomes; aortic stenosis; molecular mechanisms in valve disease; structural heart disease

(This special issue belongs to the Section Medical Research)

Exploring the Mechanisms of the Effects of Microplastics and Nanomaterials on Biological Physiological Functions

edited by

Yung-Li Wang

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2428 | Submission Open

Keywords: microplastics; nanomaterials; environmental toxicology; oxidative stress; physiological function

(This special issue belongs to the Section Physiology and Pathology)

Advances in the Rehabilitation of Stroke

edited by

Chia Huei Lin

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2318 | Submission Open

Keywords: stroke; acute stroke; chronic stroke; post-acute stroke; functional recovery; rehabilitation

(This special issue belongs to the Section Medical Research)

Advances in Cardiac Arrest: Prognostic Performance and Management

edited by

Kei Hayashida

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1662 | Submission Open

Keywords: cardiac arrest; resuscitation; emergency medicine; critical care medicine

(This special issue belongs to the Section Medical Research)

Pig Microbiota Metabolism and Intestinal Health

edited by

Qi-Ye Wang

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1331 | Submission Open

Keywords: pig microbiota; metabolism; intestinal health; gut microbiome; functional genomics; microbiome-host interactions; animal nutrition; disease resistance; gut barrier function; omics technologies; immune function; antibiotic reduction; feed efficiency; pathogen control; gastrointestinal health

(This special issue belongs to the Section Animal Science)

Intracerebral Hemorrhage: Advances and Perspectives

edited by Ane Claudia Fernandes Nunes

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1239 | Submission Open

Keywords: intracerebral hemorrhage; microangiopathic disease; cerebral microhemorrhages blood– brain barrier; small vessel disease

(This special issue belongs to the Section Physiology and Pathology)

Plant–Soil Interactions Under Global Change

edited by

Tao Zhang

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1235 | Submission Open

Keywords: plant– soil interactions; biodiversity; ecosystem; agroecosystem; natural ecosystem; sustainable development

(This special issue belongs to the Section Plant Science)

Liver Disease: Pathogenesis, Diagnosis, and Treatments

edited by Hsien-Hui Chung

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1141 | Submission Open

Keywords: alcoholic hepatitis; artificial intelligence; biomarkers; clinical trials; gut– liver axis; liver cancer; metabolic dysfunction-associated steatohepatitis; molecular targets; pharmacotherapeutic mechanisms; therapeutic strategies

(This special issue belongs to the Section Medical Research)

New Insights into Pneumonia Pathophysiology—from Lung Fibrosis to Coagulation Disorders

edited by Mihai Lazar

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1072 | Submission Open

Keywords: pneumonia pathophysiology; lung fibrosis; coagulation disorders; thromboinflammation; immune dysregulation; diagnostic biomarkers; translational medicine

(This special issue belongs to the Section Physiology and Pathology)

Brain Health for All Ages: Leave No One Behind

edited by

Tissa Wijeratne

and Dilani Wijeratne

submission deadline 31 Jan 2026 | 1 articles | Viewed by 703 | Submission Open

Keywords: brain health; neurology; neurological syndromes

(This special issue belongs to the Section Medical Research)

The Biological Impacts of Fetal Alcohol Exposure

edited by Kelly J. Huffman

submission deadline 31 Jan 2026 | 1 articles | Viewed by 661 | Submission Open

Keywords: fetal alcohol spectrum disorders; fetal alcohol syndrome; brain development; behavioral development; prenatal exposure

(This special issue belongs to the Section Reproductive and Developmental Biology)

Advances in Emergency and Critical Care Medicine

edited by

Yu-Jang Su

submission deadline 31 Jan 2026 | Viewed by 653 | Submission Open

Keywords: emergency medicine; critical care; trauma; infectious diseases; elderly

(This special issue belongs to the Section Medical Research)

Parasite Detection, Control Strategies and Risk Factors Related to Reproductive Health in Livestock

edited by

Ioannis Tsakmakidis

and

Ioannis Giantsis

submission deadline 31 Jan 2026 | Viewed by 533 | Submission Open

Keywords: livestock; parasite control; reproductive health; management

(This special issue belongs to the Section Animal Science)

Current Updates on Equidae Breeding and Genetics

edited by

María Dolores Gómez Ortiz

and

Isabel Cervantes

submission deadline 31 Jan 2026 | 1 articles | Viewed by 477 | Submission Open

Keywords: complex trait; selection; animal welfare; genomic inbreeding; horse; donkey; mule

(This special issue belongs to the Section Animal Science)

Cell Asymmetry and Polarity: Guiding Cellular Behavior and Development: Second Edition

edited by

Tadahiro Nagaoka

submission deadline 31 Jan 2026 | Viewed by 309 | Submission Open

Keywords: cell asymmetry; cell polarity; tissue morphogenesis; planar cell polarity (PCP) pathway; Wnt pathway; therapeutic implications

(This special issue belongs to the Section Cell Biology and Tissue Engineering)

Microbial Biotechnology and Biomanufacturing

edited by

Sheng Tong

Dexin Wang

and

Guirong Tang

submission deadline 31 Jan 2026 | Viewed by 177 | Submission Open

Keywords: synthetic biology tools; microbial biomanufacturing; future foods; bulk chemicals; plant natural products

(This special issue belongs to the Section Synthetic Biology and Systems Biology)

The Role of Mitochondrial Function in Cancer and Diseases and Therapeutic Explorations

edited by

Amer Ahmed

and

Barbara Illi

submission deadline 31 Jan 2026 | Viewed by 177 | Submission Open

Keywords: cancer metabolism; mitochondrial DNA (mtDNA) mutations; oxidative stress; mitophagy and autophagy; mitochondria-targeted therapy; metabolic reprograming; mitochondrial dynamics (fusion and fission); redox biology

(This special issue belongs to the Section Physiology and Pathology)

Advances in Imaging for Female Patients: Breast and Gynecological Diagnostics

edited by Silvia Gigli, Emanuele David and Giacomo Bonito

submission deadline 31 Jan 2026 | Viewed by 174 | Submission Open

Keywords: breast cancer; breast screening; gynecological cancer; mammography; CEM; ultrasound; MRI; PET/TC; radiomics; artificial intelligence

(This special issue belongs to the Section Medical Research)

Transformative Technologies in Liver Transplantation

edited by

Davide Ghinolfi

and

Lorenzo Petagna

submission deadline 31 Jan 2026 | Viewed by 169 | Submission Open

Keywords: liver; transplant; liver surgery; machine perfusion; radiomics; nanotechnology; 3D printing; gene editing

Chemical Evolutionary Pathways to Origins of Life

edited by

Claudia Huber

and Christian Seitz

submission deadline 31 Jan 2026 | Viewed by 156 | Submission Open

Keywords: origin of life; metabolism-first; early Earth; iron– sulfur world; chemical evolution ; cellularization; surface catalysis; pioneer organism

(This special issue belongs to the Section Origin of Life)

Advanced Machine Learning for Bio-Signal Processing and Health Monitoring

edited by

Amin Hekmatmanesh

submission deadline 31 Jan 2026 | Viewed by 115 | Submission Open

Keywords: brain– computer interface (BCI); electroencephalogram (EEG); machine learning; biomedical signal processing; brain computer interface; health monitoring

(This special issue belongs to the Section Medical Research)

Cancer Genetics and Genomics: From Structure to Therapy

edited by Luca Járomi and Gellért Gerencsér

submission deadline 31 Jan 2026 | Viewed by 110 | Submission Open

Keywords: epigenetics; cancer therapy; multidrug resistance (MDR); accumulation; biomarkers

(This special issue belongs to the Section Genetics and Genomics)

Mechanisms and Ecology of Migration and Homing

edited by Hynek Burda

submission deadline 1 Feb 2026 | Viewed by 125 | Submission Open

Keywords: migration; homing; navigation; spatial orientation; magnetoreception; cognitive maps; seasonality; spatial memory

(This special issue belongs to the Section Diversity and Ecology)

Advances in Endoscopic, Surgical, and Interventional Radiological Management of Gastrointestinal Diseases

edited by

Beata Jabłońska

submission deadline 6 Feb 2026 | 3 articles | Viewed by 7868 | Submission Open

Keywords: gastrointestinal disease; endoscopic cystogastrostomy; endoscopic biliary prosthesis; endoscopic pancreatic prosthesis; endoscopic necrosectomy; esophagectomy; gastrectomy; bowel resection; colectomy; pancreatectomy; hepatectomy; liver transplantation; gastroenterology; surgery; interventional radiology

(This special issue belongs to the Section Medical Research)

Genetics, Breeding and Reproduction of Honeybees: Second Edition

edited by

Xiao Chen

submission deadline 9 Feb 2026 | 2 articles | Viewed by 4306 | Submission Open

Keywords: phenomics; genetics; genomics; functional genomics; metabolomics; functional genes identification; genetics editing; genome selection; genetic evaluation; hybrid breeding; egg-laying; honey production; queen breeding; varroa resistance

(This special issue belongs to the Section Animal Science)

Regulation of Cerebrovascular Resistance in Health and Disease: From Molecules to Humans

edited by

Akos Koller

submission deadline 13 Feb 2026 | 7 articles | Viewed by 7375 | Submission Open

Keywords: cerebral blood flow; hemodynamic forces; cerebrovascular resistance; endothelium; smooth muscle; arachidonic acid metabolites; reactive oxygen species; molecular mediators; protein and mRNA expressions; brain disease conditions; transcranial Doppler measurement; EEG; lifestyle

(This special issue belongs to the Section Physiology and Pathology)

Pain Epidemiology

edited by

Gergely Fehér

submission deadline 14 Feb 2026 | Viewed by 163 | Submission Open

Keywords: pain epidemiology; chronic pain; neuropathic pain; nociplastic pain; headache; migraine; orofacial pain; low back pain

(This special issue belongs to the Section Epidemiology)

Prebiotic Chemistry: The Molecular Origins of Life

edited by

Nigel Mason

submission deadline 15 Feb 2026 | Viewed by 566 | Submission Open

Keywords: astrobiology; astrochemistry; biochemistry; computational modelling; geochemistry; metabolic pathways; lipid formation; peptide synthesis; photochemistry; radiation chemistry; RNA world; self-assembly; systems chemistry

(This special issue belongs to the Section Origin of Life)

Microbiome Dynamics: Advancing Therapeutic Development in Health and Disease

edited by

Hoonhee Seo

, Sukyung Kim and

Md Abdur Rahim

submission deadline 16 Feb 2026 | Viewed by 157 | Submission Open

Keywords: next-generation probiotics (NGPs); microbiome-based therapeutics; metagenomics and multi-omics integration; microbial biomarkers; short-chain fatty acids (SCFAs); artificial human microbiome simulators; GMP-scale production; clinical translation

(This special issue belongs to the Section Microbiology)

Omics Approaches in Antipsychotic Pharmacology

edited by

Kyle Burghardt

submission deadline 18 Feb 2026 | Viewed by 84 | Submission Open

Keywords: antipsychotics; genomics; epigenomics; transcriptomics; lipidomics; metabolomics; proteomics; human; animal

(This special issue belongs to the Section Pharmaceutical Science)

Current Challenges in Human Space Flight

edited by

Larry D. Sanford

and

Richard A. Britten

submission deadline 20 Feb 2026 | 4 articles | Viewed by 13680 | Submission Open

Keywords: cognition; microgravity; sleep; stress; Martian and lunar dust; neural stem cells and progenitors

(This special issue belongs to the Section Astrobiology)

Musculoskeletal Function and Exercise Physiology: Integrative Approaches and Emerging Insights

edited by

Robert Smith

Tyler Neltner

Dimitrije Cabarkapa

and Luke Chowning

submission deadline 20 Feb 2026 | Viewed by 194 | Submission Open

Keywords: resistance exercise; aerobic exercise; sport performance; neuromuscular; electromyography; muscle function; kinematics; kinetics; biomechanics; motion analysis; imaging techniques; muscle biopsy

(This special issue belongs to the Section Medical Research)

Mucopolysaccharidosis-Plus: From Molecular Defects to Therapeutic Strategies

edited by Zuzanna Cyske

submission deadline 20 Feb 2026 | Viewed by 71 | Submission Open

Keywords: mucopolysaccharidosis; mucopolysaccharidosis-plus syndrome; MPSPS; VPS33A; therapy; patomechanism; diagnostic; patients’ care

(This special issue belongs to the Section Medical Research)

Diagnosis, Treatment and Prognosis of Prostate Cancer

edited by

Juan Gómez Rivas

and Jesús Moreno Sierra

submission deadline 25 Feb 2026 | 1 articles | Viewed by 1566 | Submission Open

Keywords: active surveillance; hormonal treatment; personalized medicine; prostate cancer; robotic surgery; targeted therapy

(This special issue belongs to the Section Medical Research)

Nutrition, Exercise and Stress

edited by Maleah Holland-Winkler

submission deadline 25 Feb 2026 | Viewed by 504 | Submission Open

Keywords: nutrition; exercise; stress

(This special issue belongs to the Section Physiology and Pathology)

Gynecology Update: Modern Diagnostic Approaches and Innovative Therapies

edited by Szabolcs Várbíró,

Keszthelyi Márton

, Richárd Tóth and Balázs Lintner

submission deadline 26 Feb 2026 | 3 articles | Viewed by 2606 | Submission Open

Keywords: gynecologic oncology; endocrinology; reproductive medicine; fertility preservation; prevention; women’ s health innovation; quality of life; personalized therapy

(This special issue belongs to the Section Medical Research)

Conservative Management of Chronic Disease—2nd Edition

edited by

Jonathan Sinclair

submission deadline 26 Feb 2026 | 1 articles | Viewed by 706 | Submission Open

Keywords: chronic disease; conservative management; trial protocol; clinical research; interventions

(This special issue belongs to the Section Medical Research)

Biomechanics of Aging

edited by

Márcio Fagundes Goethel

and

Filipa Sousa

submission deadline 26 Feb 2026 | Viewed by 175 | Submission Open

Keywords: aging; biomechanics; musculoskeletal; gait; balance; falls; exercise; assistive devices

(This special issue belongs to the Section Physiology and Pathology)

Skin Aging and Dermatosis

edited by Edwin Lephart and Zoe D. Draelos

submission deadline 26 Feb 2026 | Viewed by 165 | Submission Open

Keywords: skin aging; chronological dermal aging; photo-aging; hormone therapy; menopause; estrogen-deficient skin; dermatosis; skin conditions

(This special issue belongs to the Section Medical Research)

The Link Between Food Safety and Microbiology

edited by

Babak Pakbin

submission deadline 26 Feb 2026 | Viewed by 161 | Submission Open

Keywords: food safety; food microbiology; beneficial microbes; food preservation; food safety enhancement

(This special issue belongs to the Section Microbiology)

Oral Health: Microbial Dynamics and Antibiotic Stewardship

edited by Kristina Peroš

submission deadline 26 Feb 2026 | Viewed by 102 | Submission Open

Keywords: oral health; oral microbiota; microbial dynamics; antibiotic stewardship

(This special issue belongs to the Section Microbiology)

Pharmacological Advances in Anticancer, Antiparasitic, and Immunomodulatory Therapies

edited by Cássio Santana Meira and Vinicius Pinto Costa Rocha

submission deadline 26 Feb 2026 | Viewed by 82 | Submission Open

Keywords: anticancer drugs; antiparasitic agents; immunomodulatory therapy; drug development

(This special issue belongs to the Section Pharmaceutical Science)

Acute Kidney Events in Intensive Care

edited by

Silvia De Rosa

submission deadline 27 Feb 2026 | 3 articles | Viewed by 6837 | Submission Open

Keywords: acute kidney events; ICU; critically ill; RRT; outcome; acute kidney disease; chronic kidney disease; biomarkers

(This special issue belongs to the Section Medical Research)

Novel Therapies for Chronic Inflammatory Diseases and Autoimmune Diseases

edited by

Emina Karahmet Sher

submission deadline 27 Feb 2026 | 3 articles | Viewed by 6547 | Submission Open

Keywords: chronic inflammatory diseases; autoimmune diseases; biomarker identification; innovative biologics; small-molecule inhibitors; gene editing technologies; cell-based therapeutics

(This special issue belongs to the Section Medical Research)

Feature Papers in Synthetic Biology and Systems Biology 2025

edited by

Pasquale Stano

submission deadline 27 Feb 2026 | 2 articles | Viewed by 3330 | Submission Open

Keywords: design and construction of synthetic biological systems; innovations in the creation of synthetic organisms; genetic circuits; and biomolecular devices; bottom-up synthetic biology; cell-free synthetic biology; tissue engineering and organoids; bioorthogonal parts; devices; systems; microcompartmentalized systems with soft or hard interfaces; theoretical considerations about synthetic biology; synthetic biology intersection with systems chemistry and bioorganic chemistry; computational modeling and simulation of biological processes; advances in computational tools and models that enhance our understanding of biological processes and systems; metabolic engineering and synthetic pathways; development of novel approaches for the production of biofuels; pharmaceuticals; and other valuable compounds; synthetic biology for approaching evolutionary problems; artificial evolution and in vitro evolution; optogenetics and related techniques; gene editing technologies; applications; and developments; education in synthetic and systems biology; cutting-edge techniques and applications of CRISPR and other gene editing tools; systems biology approaches to understanding complex biological networks; mathematical aspects of systems biology approaches; artificial photosynthesis; applications of synthetic biology in medicine; agriculture; and industry; practical applications of synthetic and systems biology in various sectors; including healthcare; agriculture; and industrial biotechnology; ethical; legal; and social implications of synthetic and systems biology; exploration of the broader implications of advancements in synthetic and systems biology; including ethical considerations and regulatory challenges and social implications

(This special issue belongs to the Section Synthetic Biology and Systems Biology)

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