Acute Kidney Events in Intensive Care

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1549

Special Issue Editor


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Centre for Medical Sciences—CISMed, University of Trento, Via S. Maria Maddalena 1, 38122 Trento, Italy
Interests: acute brain injury; acute kidney injury; blood purification in sepsis; airway management; infectious disease; extracorporeal organ support; nutrition and metabolism in critical care
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Special Issue Information

Dear Colleagues,

The aim of this Issue is to report the most recent data on renal function and its possible deterioration in critically ill patients. The kidney is a central organ in the management of intensive care patients, and thus deserves a great deal of attention, with the sole aim of improving the prognosis of these patients.

In patients admitted to intensive care units (ICUs), adverse renal events frequently occur, significantly impacting mortality and morbidity. Acute kidney injury (AKI) is the most common adverse renal event. In fact, AKI occurs in almost 50% of these patients, leading not only to an increased risk of mortality, but also to deleterious systemic effects in survivors, predisposing them to cardiovascular disease and chronic kidney disease.

This Special Issue’s purpose is to explore the advances in acute kidney events in intensive care, focusing on perspectives of interest from both a clinical perspective and for the scientific community.

Dr. Silvia De Rosa
Guest Editor

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Keywords

  • acute kidney events
  • ICU
  • critically ill
  • RRT
  • outcome
  • acute kidney disease
  • chronic kidney disease
  • biomarkers

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Published Papers (1 paper)

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Research

16 pages, 1261 KiB  
Article
Acute Kidney Injury in Patients After Cardiac Arrest: Effects of Targeted Temperature Management
by Silvia De Rosa, Sergio Lassola, Federico Visconti, Massimo De Cal, Lucia Cattin, Veronica Rizzello, Antonella Lampariello, Marina Zannato, Vinicio Danzi and Stefano Marcante
Life 2025, 15(2), 265; https://doi.org/10.3390/life15020265 - 10 Feb 2025
Viewed by 824
Abstract
Background: Cardiac arrest (CA) is a leading cause of mortality and morbidity, with survivors often developing post-cardiac arrest syndrome (PCAS), characterized by systemic inflammation, ischemia–reperfusion injury (IRI), and multiorgan dysfunction. Acute kidney injury (AKI), a frequent complication, is associated with increased mortality and [...] Read more.
Background: Cardiac arrest (CA) is a leading cause of mortality and morbidity, with survivors often developing post-cardiac arrest syndrome (PCAS), characterized by systemic inflammation, ischemia–reperfusion injury (IRI), and multiorgan dysfunction. Acute kidney injury (AKI), a frequent complication, is associated with increased mortality and prolonged intensive care unit (ICU) stays. This study evaluates AKI incidence and progression in cardiac arrest patients managed with different temperature protocols and explores urinary biomarkers’ predictive value for AKI risk. Methods: A prospective, single-center observational study was conducted, including patients with Return of Spontaneous Circulation (ROSC) post-cardiac arrest. Patients were stratified into three groups: therapeutic hypothermia (TH) at 33 °C, Targeted Temperature Management (TTM) at 35 °C, and no temperature management (No TTM). AKI was defined using KDIGO criteria, with serum creatinine and urinary biomarkers (TIMP-2 and IGFBP7) measured at regular intervals during ICU stay. Results: AKI incidence at 72 h was 31%, varying across protocols. It was higher in the No TTM group at 24 h and in the TH and TTM groups during rewarming. Persistent serum creatinine elevation and fluid imbalance were notable in the TH group. Biomarkers indicated moderate tubular stress in the TTM and No TTM groups. Conclusions: AKI is a frequent complication post-cardiac arrest, with the rewarming phase identified as critical for renal vulnerability. Tailored renal monitoring, biomarker-guided risk assessment, and precise temperature protocols are essential to improve outcomes. Full article
(This article belongs to the Special Issue Acute Kidney Events in Intensive Care)
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