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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Promising Therapeutic Horizons for Regenerative Medicine in Animals

edited by

Hussein M. El-Husseiny

and

Sharun Khan

submission deadline 28 Jul 2026 | Viewed by 279 | Submission Open

Keywords: stem cells; induced pluripotent stem cells (iPSCs); soft tissue engineering; in vivo and in vitro investigations; extracellular vesicles; preclinical studies; clinical studies; platelet-rich plasma; platelet-rich fibrin; cell-based therapy; cell-free therapy; orthopedics; cardiology

(This special issue belongs to the Section Animal Science)

New Insights into Parkinson’s Disease: From Molecular Basis to Therapy—2nd Edition

edited by

Kallirhoe Kalinderi

submission deadline 28 Jul 2026 | Viewed by 41 | Submission Open

(This special issue belongs to the Section Medical Research)

Migraine and Headache: From Pathophysiological Aspects

edited by

Jacob Genizi

submission deadline 30 Jul 2026 | 3 articles | Viewed by 4190 | Submission Open

Keywords: migraine; headache; pathophysiology; treatment; medication

(This special issue belongs to the Section Physiology and Pathology)

Prostate Cancer: 4th Edition

edited by

Paula Oliveira

and

Ana Faustino

submission deadline 30 Jul 2026 | 2 articles | Viewed by 3271 | Submission Open

Keywords: incidence; mortality; diagnosis; histopathology; imaging; treatment; prognosis; case report; animals; humans; modeling

(This special issue belongs to the Section Medical Research)

Advances in Fetal Medicine: From Prenatal Diagnosis to Fetal and Neonatal Therapy

edited by Przemysław Kosinski

submission deadline 30 Jul 2026 | 2 articles | Viewed by 1589 | Submission Open

Keywords: fetal medicine; prenatal diagnosis; non-invasive prenatal testing (NIPT); fetal imaging; fetal therapy; fetal surgery; neonatal intensive care; genetic and genomic advances; perinatal outcomes; maternal-fetal health

(This special issue belongs to the Section Reproductive and Developmental Biology)

Therapeutic Effects of Natural Products on Human Diseases—3rd Edition

edited by

Seung Ho Lee

submission deadline 30 Jul 2026 | 1 articles | Viewed by 686 | Submission Open

Keywords: natural products; natural extracts; cancer; neurodegenerative diseases; immunological disorders; metabolic diseases; oriental medicine; microorganisms; algae; functional foods

(This special issue belongs to the Section Pharmaceutical Science)

Treatment and Prognosis of Thoracic Diseases

edited by

Alessandro Gonfiotti

and

Alice Ravasin

submission deadline 30 Jul 2026 | 1 articles | Viewed by 599 | Submission Open

Keywords: thoracic malignancies; lung cancer management ; targeted therapy ; immunotherapy ; molecular diagnostics ; multidisciplinary care ; personalized treatment

(This special issue belongs to the Section Medical Research)

Recent Advances in Bone Biology

edited by Barbara Peruzzi,

Martina Leopizzi

and Giulia Battafarano

submission deadline 30 Jul 2026 | 1 articles | Viewed by 560 | Submission Open

Keywords: bone tissue engineering; bone-targeted therapies; genetic bone diseases; bone mechanotransduction; bone cell pathophysiology; bone metabolism

(This special issue belongs to the Section Physiology and Pathology)

Migraine and Headache: From Clinical and Therapeutic Aspects

edited by

Jacob Genizi

submission deadline 30 Jul 2026 | Viewed by 250 | Submission Open

Keywords: migraine; headache; treatment; medication

(This special issue belongs to the Section Medical Research)

Microorganisms Engineering and Gene-Editing Methods

edited by

Jichao Wang

Guang Zhao

and Xia Zhao

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1539 | Submission Open

Keywords: microorganisms engineering; metabolic engineering; strain optimization; gene editing; CRISPR; recombination

(This special issue belongs to the Section Genetics and Genomics)

Sports Biomechanics, Injury, and Physiotherapy

edited by Manos Stefanakis

submission deadline 31 Jul 2026 | 2 articles | Viewed by 1272 | Submission Open

Keywords: sports injuries; epidemiology; data-driven rehabilitation; objective assessment; injury prevention; return to play

(This special issue belongs to the Section Physiology and Pathology)

Vetinformatics-Driven Approaches to Animal Health and Disease

edited by

Jun-Mo Kim

and

Rajesh Kumar Pathak

submission deadline 31 Jul 2026 | 1 articles | Viewed by 710 | Submission Open

Keywords: animal health; livestock disease; vetinformatics; computational genomics; RNAseq; multi-omics; drug discovery; molecular docking; molecular dynamics simulation; vaccine design; one health

(This special issue belongs to the Section Animal Science)

Innovation in Fish Nutrition, Production Technology, and Welfare

edited by

Marian Burducea

, Liviu-Dan Miron and

Cristian-Alin Barbacariu

submission deadline 31 Jul 2026 | Viewed by 543 | Submission Open

Keywords: aquaculture; fish nutrition; fish welfare; water quality; fish disease; feed additives; rearing systems; modern feeding technologies; waste management

Skin Care and Innovation from the Perspective of Molecular Dermatology

edited by

Ewa Markiewicz

Olusola Idowu

and

Jacek C. Szepietowski

submission deadline 31 Jul 2026 | Viewed by 452 | Submission Open

Keywords: molecular dermatology; personalised skincare; ageing; natural ingredients

(This special issue belongs to the Section Physiology and Pathology)

Multimodal AI for Genomic-Clinicopathologic Integration: From Preventive Screening to Precision Diagnosis

edited by Yen-Lin Chen

submission deadline 31 Jul 2026 | Viewed by 111 | Submission Open

Keywords: multimodal data integration; artificial intelligence in medicine; genomic and health data analysis; digital pathology and image analysis; predictive modeling and risk stratification; explainable machine learning (XAI)

(This special issue belongs to the Section Biochemistry, Biophysics and Computational Biology)

Anti-Inflammatory and Natural Products

edited by

Chi-Su Yoon

submission deadline 31 Jul 2026 | Viewed by 97 | Submission Open

Keywords: anti-inflammation; macrophage; mechanism study; in vivo/in vitro model; natural products; natural products-derived compound

(This special issue belongs to the Section Pharmaceutical Science)

Genetic Regulation Mechanisms of Crop Salt–Alkali Tolerance

edited by

Zhenyuan Pan

submission deadline 31 Jul 2026 | Viewed by 60 | Submission Open

Keywords: crops; salt tolerance; genome; transcriptome; yield traits; genetic regulation mechanisms

(This special issue belongs to the Section Plant Science)

Molecular Mechanisms and Immune Regulation in Animal Diseases

edited by

Dagmara Winiarczyk

submission deadline 31 Jul 2026 | Viewed by 54 | Submission Open

Keywords: proteomics; animal diseases; mucosal immunity; biomarkers; host– pathogen interactions; immunoregulation; mass spectrometry; comparative medicine; veterinary proteomics; systems biology

(This special issue belongs to the Section Animal Science)

Precision Oncology Through Diagnostic Imaging and Theranostics

edited by

Wensi Tao

, Luyuan Li and Yu-Ping Yang

submission deadline 31 Jul 2026 | Viewed by 53 | Submission Open

Keywords: cancer imaging; molecular imaging; theranostics; nanomedicine; imaging biomarkers; precision oncology

(This special issue belongs to the Section Medical Research)

Mechanisms and Treatment of Eye and Vision Conditions

edited by Jeong-Min Hwang

submission deadline 31 Jul 2026 | Viewed by 45 | Submission Open

Keywords: mechanism; treatment; eye; vision

(This special issue belongs to the Section Medical Research)

Compulsive Disorder: Understanding of the Pathophysiology and Therapeutic Implications

edited by

Donatella Marazziti

submission deadline 31 Jul 2026 | Viewed by 45 | Submission Open

Keywords: obsessive– compulsive disorder; compulsivity; cortico-striato-thalamo cortical circuits; cognitive inflexibility; glutamatergic modulation; neuroimmune mechanisms; neuromodulation; deep brain stimulation; precision psychiatry

(This special issue belongs to the Section Physiology and Pathology)

Black Holes in Atrial Fibrillation Therapy

edited by Roberto Cemin

submission deadline 31 Jul 2026 | Viewed by 41 | Submission Open

Keywords: atrial fibrillation; clinical guidelines; stroke prevention; oral anticoagulation; CHA2DS2-Va Score; catheter ablation; left atrial appendage closure; personalized medicine

(This special issue belongs to the Section Medical Research)

Building the Future of Veterinary Medicine: Foundational Data in Physiology and Pathology

edited by Bokyeong Ryu

submission deadline 31 Jul 2026 | Viewed by 33 | Submission Open

Keywords: veterinary physiology; veterinary pathology; veterinary database; multimodal evidence

(This special issue belongs to the Section Animal Science)

Prevention and Control of Post-Radiotherapy Complications in Head and Neck Cancer

edited by Sung-Chan Shin

submission deadline 31 Jul 2026 | Viewed by 30 | Submission Open

Keywords: head and neck cancer; radiotherapy complications; post-radiation toxicity; radiation-induced injury; prevention and management; oral and pharyngeal toxicity; salivary gland dysfunction; osteoradionecrosis; functional rehabilitation; biomarkers and prediction models

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Skin Models and 3D Tissue: Fungal Infections and Antifungals

edited by Marisa Meloni,

Salvatore Prete

and Antonio Del Prete

submission deadline 5 Aug 2026 | Viewed by 32 | Submission Open

Keywords: mycosis; 3D tissue in vitro models; clinical and non clinical models; antifungal therapy

(This special issue belongs to the Section Microbiology)

Challenges and Innovations in Biomaterials for Tissue Engineering

edited by

Fei Fan

, Donny Hanjaya-Putra and Loan Bui

submission deadline 20 Aug 2026 | Viewed by 111 | Submission Open

Keywords: hydrogels; nanoparticles; extracellular matrix; microfluidics; bio-responsive; tissue engineering; regenerative medicine

(This special issue belongs to the Section Cell Biology and Tissue Engineering)

Recent Advances in Head and Neck Disorders

edited by

Cosmin Ioan Faur

and Maximilian Dindelegan

submission deadline 20 Aug 2026 | Viewed by 80 | Submission Open

Keywords: molecular pathology; biomedical technology; systems biology

(This special issue belongs to the Section Medical Research)

Spotlight on Cardiovascular Physiology and Related Diseases: Impact of Sex Differences

edited by

Helena Lenasi

submission deadline 21 Aug 2026 | Viewed by 31 | Submission Open

Keywords: cardiovascular physiology; microcirculation; endothelium; oxidative stress; sex differences; mathematical algorithms for biological signal analysis; metabolic diseases; hyperglycemia

(This special issue belongs to the Section Medical Research)

Oral Health and Systemic Conditions: From Biological Insights to Multidimensional Interventions

edited by

Gerson Aparecido Foratori-Junior

Carla Andreotti Damante

and

Nao Taniguchi (Nao Suzuki)

submission deadline 27 Aug 2026 | Viewed by 237 | Submission Open

Keywords: oral health ; periodontitis ; dental care ; tooth loss ; oral cancer ; facial esthetics ; salivary biomarkers ; systemic– oral health interactions ; non-invasive therapies ; clinical and epidemiological research

(This special issue belongs to the Section Medical Research)

Molecular Muscle Adaptations Across the Lifespan

edited by S. Kyle Traivs and

Sime Versic

submission deadline 30 Aug 2026 | 1 articles | Viewed by 4295 | Submission Open

Keywords: muscle tissue; muscle physiology; molecular pathways; therapeutics

(This special issue belongs to the Section Physiology and Pathology)

Skin Diseases and Dermatologic Comorbidities

edited by Alessia Paganelli,

Emanuele Scala

and

Flavia Persechino

submission deadline 30 Aug 2026 | 3 articles | Viewed by 4097 | Submission Open

Keywords: skin diseases; dermatologic comorbidities; metabolic impairment; autoimmunity; cytokines; serum markers

(This special issue belongs to the Section Physiology and Pathology)

Metabolic Eye Diseases: From Tomography to Clinical Prediction

edited by

Akio Oishi

and

Nilufer Yesilirmak

submission deadline 30 Aug 2026 | Viewed by 301 | Submission Open

Keywords: metabolic eye diseases; ophthalmic tomography and imaging biomarkers; diabetic retinopathy and systemic metabolic disorders; mitochondrial dysfunction and optic neuropathies; corneal metabolic diseases and ocular surface disorders; artificial intelligence in clinical prediction of eye diseases; metabolic pathways and retinal degeneration; translational research in metabolic ophthalmology

(This special issue belongs to the Section Physiology and Pathology)

Global Burden of Chronic Pain: Advances and Challenges in Pain Management and Clinical Practice

edited by Saba Javed and Billy Huh

submission deadline 30 Aug 2026 | Viewed by 101 | Submission Open

Keywords: chronic pain syndrome; cancer pain syndrome; neuromodulation; intrathecal pump; opioids; nerve blocks; joint injections

(This special issue belongs to the Section Medical Research)

Molecular Mechanisms and Therapeutic Effects of Drugs in Cancer—2nd Edition

edited by

Elżbieta Janina Płuciennik

Żaneta Kałuzińska-Kołat

and

Damian Kołat

submission deadline 31 Aug 2026 | 4 articles | Viewed by 8876 | Submission Open

Keywords: cancer; therapy; cancer drug; molecular mechanism; signaling pathways; targeted therapy; in silico drug response studies; innovative cancer treatment

(This special issue belongs to the Section Medical Research)

Advances in Biomedical Frontier Technologies and Disease Diagnosis

edited by

Alexey Yaremenko

submission deadline 31 Aug 2026 | 1 articles | Viewed by 3228 | Submission Open

Keywords: nanomedicine ; biomaterials ; gene therapy ; drug delivery ; bacteriotherapy ; nanobiotechnology ; hereditary diseases ; bioinformatics ; personalized medicine ; smart biomaterials

(This special issue belongs to the Section Medical Research)

Effects of Environmental Factors on Challenges of Plant Breeding: 2nd Edition

edited by

Katalin Magyar-Tábori

and

Nóra Mendler-Drienyovszki

submission deadline 31 Aug 2026 | Viewed by 330 | Submission Open

Keywords: plant breeding; winter hardiness; sowing time; adaptation to cold/frost; physiology of cold/frost tolerance; snow cover

(This special issue belongs to the Section Plant Science)

Innovations in Nuclear Medicine and Molecular Imaging

edited by

Christian Kühnel

and

Yiannis Parpottas

submission deadline 31 Aug 2026 | Viewed by 98 | Submission Open

Keywords: nuclear medicine; molecular imaging; PET; SPECT; radiopharmaceuticals; theranostics; quantitative imaging; artificial intelligence; dosimetry; precision medicine

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Progress in Rehabilitation Interventions for Heart Failure

edited by

João Morais

, Jhonatan Betancourt-Peña, Iago Portela and Mauricio Hernández-Carrillo

submission deadline 31 Aug 2026 | Viewed by 90 | Submission Open

Keywords: heart failure; rehabilitation; exercise; interdisciplinary; telerehabilitation

(This special issue belongs to the Section Medical Research)

Molecular Pathways Shaping Head and Neck Cancer Care

edited by

Albert Yoon-Kyu Han

submission deadline 31 Aug 2026 | Viewed by 74 | Submission Open

Keywords: head and neck cancer; molecular pathways; tumor microenvironment; precision oncology; translational research

(This special issue belongs to the Section Medical Research)

Research Advances in Wetland Ecology

edited by

Yuxiang Yuan

and

Yunlong Yao

submission deadline 31 Aug 2026 | Viewed by 42 | Submission Open

Keywords: wetland; restoration; function; plant; algae; lake eutrophication; interspecific relationship; biogeochemical cycling; climate change

(This special issue belongs to the Section Diversity and Ecology)

The Biochemistry of Venoms: Exploring Molecular Diversity, Structural Mechanisms, and Their Biotechnological Uses

edited by

Malson Neilson Lucena

and Ludovico Migliolo

submission deadline 31 Aug 2026 | Viewed by 39 | Submission Open

Keywords: biochemistry of venoms; venomics; diversity of toxins; mechanism of action; bioprospecting

(This special issue belongs to the Section Pharmaceutical Science)

Cellular and Molecular Biology Behind Human Cognition

edited by Simone Battaglia and Masaru Tanaka

submission deadline 31 Aug 2026 | Viewed by 34 | Submission Open

Keywords: cognitive biology; synaptic and cellular plasticity; non-invasive brain stimulation techniques; synaptic and circuit plasticity; cognitive resilience; biomarkers of cognitive function; neuroinflammation and neurodegeneration; translational neuroscience; neuroplasticity; precision medicine: biomarkers; neurochemical

(This special issue belongs to the Section Physiology and Pathology)

Diagnosis, Treatment and Prognosis of Head and Neck Disorders

edited by

Geng-He Chang

submission deadline 31 Aug 2026 | Viewed by 29 | Submission Open

Keywords: head and neck disorders ; head and neck cancer ; otolaryngology ; diagnostic imaging and endoscopy ; targeted therapy and immunotherapy ; biomarkers and molecular pathology ; precision medicine ; prognostic models and outcomes ; translational research

(This special issue belongs to the Section Medical Research)

Intensive Care Medicine: Current Concepts and Future Perspectives

edited by Shinichi Watanabe

submission deadline 31 Aug 2026 | Viewed by 21 | Submission Open

Keywords: intensive care; early mobilization; sepsis; mechanical ventilation; rehabilitation; artificial intelligence; PICS; multidisciplinary collaboration

(This special issue belongs to the Section Medical Research)

Chronic Kidney Diseases: Epidemiology, Diagnosis, and Treatment

edited by Stefanos K. Roumeliotis

submission deadline 31 Aug 2026 | Viewed by 20 | Submission Open

Keywords: chronic kidney disease; end stage kidney disease; hemodialysis; peritoneal dialysis; mitochondria; oxidative stress; vascular calcification

(This special issue belongs to the Section Medical Research)

Vascular Disease: Etiologic, Diagnostic, Prognostic and Therapeutic Research—3rd Edition

edited by

Dan Mircea Olinic

and

Agata Stanek

submission deadline 31 Aug 2026 | Viewed by 17 | Submission Open

Keywords: vascular diseases; etiology; diagnosis; prognosis; therapy

(This special issue belongs to the Section Medical Research)

A Paradigm Shift in Airway and Pain Management—3rd Edition

edited by

Jui An Lin

submission deadline 31 Aug 2026 | Viewed by 1 | Submission Open

Keywords: airway management; difficult airway; video intubating stylet; pain management; ultrasonography; motor-sparing strategies; nerve block; regenerative medicine; transarterial embolization for pain management; joint denervation for pain management; rTMS (repetitive transcranial magnetic stimulation); central post-stroke pain; neuromodulation

(This special issue belongs to the Section Medical Research)

Novel Insights into Stress and Nutritional Regulation in Animals

edited by Hao-Yang Sun,

Qi-Ye Wang

, Zhan-Wei Teng and Xiao Liu

submission deadline 1 Sep 2026 | Viewed by 9 | Submission Open

Keywords: stress; nutrition; resilience; gut– X axis; microbiome; precision nutrition; multi-omics

(This special issue belongs to the Section Animal Science)

Plants: Emerging Bio-Manufacturing Chassis for Bioactive Molecules

edited by

Jianfeng Xu

submission deadline 15 Sep 2026 | Viewed by 38 | Submission Open

Keywords: plant biotechnology; metabolic engineering; secondary metabolite; recombinant proteins; synthetic biology; biopharmaceuticals; plant cell culture; molecular farming

(This special issue belongs to the Section Plant Science)

Translational Neuro-Oncology: Molecular Insights, Bioinformatics, and Technological Innovations

edited by Felix Mircea Brehar

submission deadline 20 Sep 2026 | Viewed by 79 | Submission Open

Keywords: translational neuro-oncology; central nervous system tumors; molecular and cellular mechanisms; multi-omics and biomarkers; bioinformatics and systems biology; artificial intelligence in medicine; radiomics and radiogenomics; precision neurosurgery; experimental and clinical research; therapeutic innovation in neuro-oncology

(This special issue belongs to the Section Physiology and Pathology)

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