Arbovirus: Infection, Immunity and Antiviral Research

Dear Colleagues,

We recently assembled a Special Issue, which consists of a series of papers that focuses on various aspects of the arthropod-borne virus (arbovirus) infections. Arboviruses are a diverse group of viruses. Arboviruses from the genera flavivirus and alphavirus are the most important human arboviruses among the major causes of emerging infectious diseases. This Special Issue, edited by Dr. Yongfen Xu and Dr. Mingzhe Guo, will delve into the host environment adaptation and modulation, immunity response and antiviral strategy revolving around the arbovirus. Arbovirus has evolved complex mechanisms to antagonize innate immunity response, the dissection of the underlying mechanisms could pave the way for the development of a new antiviral-regimen that can underdo the suppression on innate immunity. The cross activity of arbovirus of the flaviviridae family (genus Flavivirus) antigen complicates the design and assessment of arbovirus vaccine, new insights in antibody-dependent enhancement (ADE) phenomenon is crucial for the arbovirus vaccine development. With the rapid development of artificial intelligence-guided design and screening of anti-viral compounds, the field will witness the advent of a variety of novel small anti-arbovirus compounds. The integration of these forefronts in arbovirus has the potential to move the arbovirus research to the next chapter.

Dr. Yongfen Xu
Dr. Mingzhe Guo
Guest Editors

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