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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Primary Sclerosing Cholangitis: Pathogenesis, Diagnosis and Emerging Therapies

edited by Konstantinos H. Katsanos and

Fotios S. Fousekis

submission deadline 25 Apr 2026 | 2 articles | Viewed by 1474 | Submission Open

Keywords: cholangiocarcinoma; primary sclerosing cholangitis; cholestatic; inflammatory bowel disease; liver

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

New Advances in Procedures for the Diagnosis and Treatment of Cardiovascular Disease

edited by

Alexandru Burlacu

and

Adrian Covic

submission deadline 25 Apr 2026 | Viewed by 1375 | Submission Open

Keywords: cardiovascular disease; diagnostic procedures; therapeutic advancements; minimally invasive interventions; precision medicine; imaging technologies; catheter-based treatments; translational research; interventional cardiology; clinical innovations

(This special issue belongs to the Section Cardiovascular Medicine)

General Surgical Oncology: Evolving Paradigms and Contemporary Challenges

edited by

Federica Ferracci

and

Antonio Sommariva

submission deadline 25 Apr 2026 | 1 articles | Viewed by 1166 | Submission Open

Keywords: surgical oncology; minimally invasive surgery; robotic surgery; multidisciplinary cancer care; artificial intelligence in surgery; perioperative management; precision oncology; complex tumor resection; integrated surgical therapies; oncologic surgery innovation

(This special issue belongs to the Section Oncology)

Urologic Neoplasms: Recent Advances and Future Perspectives

edited by

Dorit E. Zilberman

submission deadline 25 Apr 2026 | 1 articles | Viewed by 828 | Submission Open

Keywords: robotic surgery; laparoscopic surgery; immunotherapy; chemotherapy; radiotherapy; prostate cancer; renal cancer; bladder cancer; upper urinary tract neoplasm; testicular cancer; penile cancer

(This special issue belongs to the Section Oncology)

Recent Advances in Pulmonary Embolism and Thrombosis: 2nd Edition

edited by

Andrea Boccatonda

and Elena Campello

submission deadline 25 Apr 2026 | 1 articles | Viewed by 612 | Submission Open

Keywords: pulmonary embolism; embolism and thrombosis; thrombus aspiration for pulmonary embolism; deep vein thrombosis; venous thromboembolism

(This special issue belongs to the Section Respiratory Medicine)

New Advances in Cleft Lip and Palate and Facial Plastic Surgery

edited by

Michael Schwaiger

, Wolfgang Zemann and Rainer Lutz

submission deadline 25 Apr 2026 | 1 articles | Viewed by 440 | Submission Open

Keywords: cleft lip repair; rhinoplasty; secondary rhinoplasty; cleft rhinoplasty; facial plastic surgery; nasolabial area; upper lid surgery

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Robot-Assisted Surgery: Current Trends and Future Directions

edited by

Michele Di Dio

, Claudio Bisegna and Michele Morelli

submission deadline 25 Apr 2026 | Viewed by 414 | Submission Open

Keywords: robotic surgery; minimally invasive surgery; urology; artificial intelligence; augmented reality; public health; innovation; laparoscopic surgery; surgical platforms; surgical outcomes

(This special issue belongs to the Section General Surgery)

Recent Developments in Reproductive Endocrinology

edited by Birute Žilaitiené and Jonas Čeponis

submission deadline 25 Apr 2026 | Viewed by 350 | Submission Open

Keywords: hypogonadism; infertility; sex hormone deficiency; reproductive endocrinology; sexual health; assisted reproduction

(This special issue belongs to the Section Endocrinology & Metabolism)

Sarcoma—Clinical Updates: 2nd Edition

edited by

Julia Visgauss

submission deadline 25 Apr 2026 | 1 articles | Viewed by 300 | Submission Open

Keywords: sarcoma; osteosarcoma; ewing’ s sarcoma; chondrosarcoma; soft-tissue sarcoma; undifferentiated pleo-morphic sarcoma; liposarcoma; leiomyosarcoma; rhabdomyosarcoma; metastatic sarcoma; targeted molecular therapy; immunotherapy; orthopedic oncology

(This special issue belongs to the Section Oncology)

Novel Diagnostic and Therapeutic Approaches to Urologic Oncology

edited by

Cosmin-Victor Ene

, Bogdan Florin Geavlete and

Cristian I. Surcel

submission deadline 25 Apr 2026 | Viewed by 217 | Submission Open

Keywords: diagnosis; therapy; up-to-date; uro-oncologic pathology

(This special issue belongs to the Section Oncology)

New Concepts in Minimally Invasive Spine Surgery

edited by

Yi Lu

and Michael Y. Wang

submission deadline 25 Apr 2026 | Viewed by 191 | Submission Open

Keywords: minimally invasive spine surgery; image navigation; tubular retractor; endoscopic spine surgery; virtual and aug-mented reality; lateral spine surgery

(This special issue belongs to the Section Clinical Neurology)

Liver Failure: Current Status and Future Opportunities

edited by

Stephen Riordan

submission deadline 25 Apr 2026 | Viewed by 107 | Submission Open

Keywords: acute liver failure; acute-on-chronic liver failure; portal hypertension; hepatic encephalopathy; pathogenesis; management

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

New Clinical Advances in Orthopedic Oncology

edited by

Julia Visgauss

submission deadline 25 Apr 2026 | Viewed by 93 | Submission Open

Keywords: orthopedic oncology; sarcoma; soft-tissue sarcoma; osteosarcoma; chondrosarcoma; Ewings sarcoma; giant cell tumor; limb salvage; mega-prosthetic reconstruction; targeted molecular therapy; immunotherapy

(This special issue belongs to the Section Orthopedics)

Emerging Surgical Techniques in the Management of Urological Diseases

edited by

Riccardo Lombardo

submission deadline 25 Apr 2026 | Viewed by 90 | Submission Open

Keywords: minimally invasive; robotics; partial nephrectomy; radical prostatectomy; focal therapy; benign prostatic hyperplasia; prostate cancer; bladder cancer

(This special issue belongs to the Section Nephrology & Urology)

Diagnosis, Treatment and Prognosis of Coronary Heart Disease: 2nd Edition

edited by

Simona Giubilato

submission deadline 25 Apr 2026 | Viewed by 89 | Submission Open

Keywords: coronary heart disease; acute coronary syndrome; chronic coronary syndrome; ischemia with no obstructive coronary arteries (INOCA); guideline-directed optimal medical therapy; precision medicine; artificial intelligence; interventional cardiology; percutaneous coronary intervention (PCI)

(This special issue belongs to the Section Cardiology)

Advances in Reconstructive and Aesthetic Plastic Surgery

edited by

Rafael Loucas

submission deadline 25 Apr 2026 | Viewed by 87 | Submission Open

Keywords: reconstructive plastic surgery; aesthetic innovation; fat grafting; microsurgery; regenerative medicine; cell-enriched lipotransfer; 3D imaging; minimally invasive techniques; hybrid injectables

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Complex Scenarios in Reverse Shoulder Arthroplasty: Bone Loss, Revisions, and Surgical Solutions

edited by Francesco Franceschi, Angelo Baldari and Antonio Caldaria

submission deadline 25 Apr 2026 | Viewed by 71 | Submission Open

Keywords: shoulder arthroplasty; revision shoulder arthroplasty; humeral fracture; failed shoulder prosthesis; bone loss management; implant failure

(This special issue belongs to the Section Orthopedics)

Personalized Therapy and Clinical Outcome for Retinal Diseases

edited by

Takeshi Iwase

submission deadline 25 Apr 2026 | Viewed by 64 | Submission Open

Keywords: retinal diseases; retinal imaging; clinical outcomes; artificial intelligence; biomarkers; optical coherence tomography (OCT); vitrectomy

(This special issue belongs to the Section Ophthalmology)

Sex- and Age-Related Differences in Exercise Response: Clinical Implications for Health and Disease

edited by

Rafael A. Casuso

submission deadline 26 Apr 2026 | 2 articles | Viewed by 1279 | Submission Open

Keywords: exercise intervention; clinical exercise physiology; sex differences; age-related response; metabolic disorders; personalized medicine; physical activity; chronic disease management

(This special issue belongs to the Section Sports Medicine)

Recent Advances in the Diagnosis and Treatment of Gastrointestinal Diseases

edited by

Ahamed Khalyfa

submission deadline 27 Apr 2026 | 5 articles | Viewed by 5154 | Submission Open

Keywords: advanced endoscopy; innovation in GI; pathophysiology of GI disorders; artificial intelligence in GI; gastrointestinal diseases

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Advancing Minimally Invasive Spine Surgery: A Special Edition on Endoscopic Spine Surgery

edited by

Adham M. Khalafallah

and Gregory W. Basil

submission deadline 28 Apr 2026 | 4 articles | Viewed by 6924 | Submission Open

Keywords: minimally invasive spine surgery (MIS); endoscopic spine surgery (ESS); spine surgery; percutaneous spine surgery; full-endoscopic spine surgery; biportal endoscopic spine surgery (BESS); unilateral biportal endoscopy (UBE); percutaneous endoscopic lumbar discectomy (PELD); endoscopic decompression; transforaminal endoscopic lumbar discectomy (TELD); interlaminar endoscopic lumbar discectomy (IELD); endoscopic lumbar fusion; endoscopic transforaminal lumbar interbody fusion (Endo-TLIF)

(This special issue belongs to the Section Clinical Neurology)

Recent Advances and Clinical Outcomes of Hip and Knee Arthroplasty

edited by

Andrea Volpin

submission deadline 28 Apr 2026 | 3 articles | Viewed by 2758 | Submission Open

Keywords: hip arthroplasty; knee arthroplasty; joint replacement; clinical outcomes; surgical innovation; patient recovery; prosthetics; perioperative care

(This special issue belongs to the Section Orthopedics)

Selected Papers from the 3rd International Online Conference on Clinical Medicine

edited by

Kent Doi

and

Francisco Guillen-Grima

submission deadline 28 Apr 2026 | 1 articles | Viewed by 1608 | Submission Open

Keywords: cardiology; cardiovascular medicine; nephrology; urology; emergency medicine; nuclear medicine & radiology; general surgery; clinical rehabilitation; respiratory medicine; anesthesiology

Current Trends in Hand Surgery

edited by

Alexandre Kaempfen

and Florian Frueh

submission deadline 28 Apr 2026 | 1 articles | Viewed by 1208 | Submission Open

Keywords: microsurgery; minimally invasive; arthroscopy; sonography; nerve surgery; joint replacement

(This special issue belongs to the Section Orthopedics)

Symptoms and Treatment of Cardiac Amyloidosis

edited by Syed Bukhari

submission deadline 28 Apr 2026 | Viewed by 275 | Submission Open

Keywords: cardiac amyloidosis; transthyretin amyloidosis; light chain amyloidosis; cardiac magnetic resonance; echocardiography; nuclear scintigraphy; endomyocardial biopsy; gene silencers; transthyretin stabilizers; immunotherapy

(This special issue belongs to the Section Cardiology)

Periodontal and Other Associated Oral Diseases: Diagnosis and Management in the Context of Systemic Pathology, 2nd Edition

edited by

Silvia Martu

Liliana-Georgeta Foia

and

Maria Alexandra Mârțu

submission deadline 30 Apr 2026 | 4 articles | Viewed by 7916 | Submission Open

Keywords: periodontitis; oral diseases; periimplantitis; biomarkers; cytokines; oxidative stress markers; PCR test; point-of-care test; CBCT; periodontal treatment; immunomodulatory therapy; local drug delivery

(This special issue belongs to the Section Otolaryngology)

Sequelae of COVID-19: Clinical to Prognostic Follow-Up

edited by

Mariana Tudoran

and

Cristina Tudoran

submission deadline 30 Apr 2026 | 6 articles | Viewed by 5362 | Submission Open

Keywords: COVID-19; post-COVID-19 syndromes; sequelae of COVID-19; pathophysiological pathways; multiorgan sequelae; long-term management of post-COVID-19 syndromes; quality of life; long-term prognosis of COVID-19

(This special issue belongs to the Section Vascular Medicine)

Rehabilitation Strategies for Neurological Disorders: Advances and Insights

edited by Delia Cinteză and Mihai Berteanu

submission deadline 30 Apr 2026 | 4 articles | Viewed by 3582 | Submission Open

Keywords: neurorehabilitation; physical medicine; virtual reality; AI in rehabilitation medicine; robotic rehabilitation; telerehabilitation; advanced technologies; upper neuromotor lesions; peripheral neuropathies; wearable sensor devices; assessment; goal-setting; individual rehabilitation plan

(This special issue belongs to the Section Clinical Rehabilitation)

Interstitial Lung Diseases: New Treatments and Future Directions

edited by Justyna Fijołek

submission deadline 30 Apr 2026 | 1 articles | Viewed by 3580 | Submission Open

Keywords: Interstitial Lung Disease (ILD); pulmonary fibrosis; orphan lung disease; AAV-ILD; occupational ILD; rheumatic lung disease; treatment strategies; emerging therapies; precision medicine; future directions

(This special issue belongs to the Section Respiratory Medicine)

Advances in Gastroenterological Surgery

edited by Alan Biloslavo and Antonio La Greca

submission deadline 30 Apr 2026 | 3 articles | Viewed by 3109 | Submission Open

Keywords: mini-invasive surgery; technology; artificial intelligence; negative pressure; indocyanine green; ultrasound; GE surgery; emergency surgery; precision surgery

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Diabetic Retinopathy Screening: Current Advances and Future Options

edited by

Alauddin Bhuiyan

and

Roland Theodore Smith

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1353 | Submission Open

Keywords: diabetic retinopathy; diabetic retinopathy screening; retinal imaging; age-related macular degeneration; artificial intelli-gence; image analysis; color fundus photography; optical coherence tomography imaging; telemedicine

(This special issue belongs to the Section Ophthalmology)

New Advances in the Management of Voice Disorders: 2nd Edition

edited by

Ben Barsties v. Latoszek

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1317 | Submission Open

Keywords: voice disorders; laryngology; laryngoscope; acoustic analysis; dysphonia; voice surgery; diagnosis; treatment; rehabilitation; vocal folds; voice assessment/measures

(This special issue belongs to the Section Otolaryngology)

Clinical Challenges and Innovations in Cochlear Implantation and Hearing Rehabilitation

edited by

Meredith Holcomb

submission deadline 30 Apr 2026 | 1 articles | Viewed by 359 | Submission Open

Keywords: cochlear implant outcomes; clinical efficiency; barriers to care; cochlear implant surgery; cochlear implant referral; cochlear implant evaluation; cochlear implant candidacy; rehabilitation; rehabilitation strategies; quality of life

(This special issue belongs to the Section Otolaryngology)

Skin Cancers: Update on Clinical Treatment and Management

edited by Nazzaro Gianluca

submission deadline 30 Apr 2026 | Viewed by 203 | Submission Open

Keywords: basal cell carcinoma; squamous cell carcinoma; melanoma; skin cancers; dermoscopy; ultrasonography; immunotherapy; biomarker; prevention; diagnosis; treatment; innovative treatments; prognosis

(This special issue belongs to the Section Dermatology)

New Clinical Advances in Depressive Disorders and Treatment-Resistant Depression

edited by Giacomo d'Andrea and Miriam Olivola

submission deadline 30 Apr 2026 | Viewed by 135 | Submission Open

Keywords: treatment-resistant depression; MDD; ketamine; esketamine; rTMS; psylocibin; bipolar depression; clinical pheno-typing; precision psychiatry; biomarkers

(This special issue belongs to the Section Mental Health)

New Clinical Advances in Psoriasis and Psoriatic Arthritis: 2nd Edition

edited by

Diego Orsini

and Alessandra Narcisi

submission deadline 30 Apr 2026 | Viewed by 125 | Submission Open

Keywords: psoriasis; psoriatic arthritis; inflammatory skin disease; inflammatory autoimmune disease; immunotherapy; autoimmunity; comorbidities; therapeutic; diagnosis; treatment; management; biologics

(This special issue belongs to the Section Dermatology)

Advances in Clinical Craniofacial Reconstructive Surgery

edited by Rami S. Kantar

submission deadline 30 Apr 2026 | Viewed by 116 | Submission Open

Keywords: craniofacial; craniofacial conditions; craniofacial surgery; cleft; cleft lip; cleft palate; reconstructive surgery; craniofacial anomalies

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Orthopedic Approaches to Acute Trauma: Insights and Strategies in Trauma Care

edited by

Gianfilippo Caggiari

submission deadline 30 Apr 2026 | Viewed by 115 | Submission Open

Keywords: acute trauma; orthopedic surgery; fractures and dislocations; ligament injuries; cartilage lesions; post-traumatic degeneration; emergency trauma care; surgical and non-surgical management; rehabilitation strategies; musculo-skeletal injury outcomes

(This special issue belongs to the Section Orthopedics)

Insight into Infectious Disease Epidemiology and Public Health

edited by

Francesco Rosiello

and Filomena Pietrantonio

submission deadline 30 Apr 2026 | Viewed by 92 | Submission Open

Keywords: gender medicine; health management; public health; infectious disease; sindemics

(This special issue belongs to the Section Infectious Diseases)

Surgical Insights into Foot and Ankle Diseases

edited by Konstantinos Tsikopoulos

submission deadline 30 Apr 2026 | Viewed by 81 | Submission Open

Keywords: lower limb surgery; infection research; foot and ankle

(This special issue belongs to the Section Orthopedics)

Clinical Updates and New Perspectives of Chronic Pain

edited by Yohannes W. Woldeamanuel

submission deadline 30 Apr 2026 | Viewed by 80 | Submission Open

Keywords: circadian rhythms; chronic pain; clock genes; neuroinflammation; chronotherapy; migraine; cancer survivors; sex differences; racial disparities; personalized medicine

(This special issue belongs to the Section Clinical Neurology)

Advances in Cardiovascular Computed Tomography (CT)

edited by

David C. Rotzinger

submission deadline 30 Apr 2026 | Viewed by 74 | Submission Open

Keywords: computed tomography angiography; cardiovascular imaging; contrast media; spectral computed tomography; quantitative imaging; coronary artery disease; aortic disease; pulmonary embolism; structural heart disease

(This special issue belongs to the Section Cardiovascular Medicine)

Head and Neck Cancer: Clinical Diagnostics and Treatments

edited by Matti Anniko

submission deadline 30 Apr 2026 | Viewed by 67 | Submission Open

Keywords: head and neck cancer; treatment; surgery; chemotherapy; immunotherapy; diagnostics

(This special issue belongs to the Section Otolaryngology)

Antithrombotic Therapy in Special and Overlooked Populations with Cardiovascular Diseases

edited by

Leonardo De Luca

submission deadline 30 Apr 2026 | Viewed by 55 | Submission Open

Keywords: antithrombotic therapy; high-risk patients; PCI; bleeding risk; atrial fibrillation; individualized treatment; real-world evidence; complex cardiovascular disease

(This special issue belongs to the Section Cardiovascular Medicine)

Congenital Heart Disease in Adults (ACHD): Diagnosis, Therapy, and Clinical Management

edited by Mirosław Kowalski

submission deadline 30 Apr 2026 | Viewed by 23 | Submission Open

Keywords: congenital cardiac defect in adults; right ventricular failure; strain echocardiography; ventricular mechanics; cardiac resynchronizing therapy (CRT); Fontan operation; protein-losing enteropathy (PLE)

(This special issue belongs to the Section Cardiology)

Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) and Concomitant Illnesses: Diagnostic and Therapeutic Implications

edited by Kamran Qureshi and Lewis Frey

submission deadline 30 Apr 2026 | Viewed by 22 | Submission Open

Keywords: metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic dysfunction-associated steatohepatitis (MASH); chronic liver diseases; metabolic syndrome; viral hepatitis; autoimmune liver diseases

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

The Role of Cardiac Rehabilitation After Myocardial Infarction, Coronary Artery Bypass Surgery, and in Other Cardiac Diseases

edited by

Aneta Aleksova

submission deadline 1 May 2026 | 3 articles | Viewed by 5621 | Submission Open

Keywords: cardiac rehabilitation; coronary artery disease; myocardial infarction; coronary artery bypass surgery; heart failure; ventricular assist device; heart transplantation; cardiomyopathies; cardiac remodeling; illness perception; treatment adherence; gender difference; biomarkers; endothelial function

(This special issue belongs to the Section Cardiology)

Recent Advancements in Periodontal and Peri-Implant Disease Management

edited by

João Martins de Mello-Neto

and Leticia Helena Theodoro

submission deadline 5 May 2026 | Viewed by 241 | Submission Open

Keywords: periodontal disease; peri-implantitis; periodontal medicine; complications and management

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Advancements and Challenges in Reconstructive Urology and Urethral Surgery

edited by

Francesco Chierigo

submission deadline 10 May 2026 | 3 articles | Viewed by 3303 | Submission Open

Keywords: reconstructive urology; urethral surgery; urethroplasty; minimally invasive surgery; robotic-assisted surgery; urinary tract reconstruction; surgical innovation; patient-reported outcomes

(This special issue belongs to the Section Nephrology & Urology)

Advances in Chronic Pain and Related Management

edited by

Sabine Sator

submission deadline 10 May 2026 | Viewed by 132 | Submission Open

Keywords: chronic pain; musculoskeletal pain; neuropathic pain; fibromyalgia syndrome; somatoform disorder; post-COVID syndrome; small fiber disease; invasive pain therapy; vagus stimulation

(This special issue belongs to the Section Anesthesiology)

Displaying special issue 1151-1200 on page 24 of 31.

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