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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances and Updates in Migraine
edited by and Carl H. Göbel
submission deadline 25 Feb 2027 | 6 articles | Viewed by 5747 | Submission Open
Keywords: migraine; chronic migraine; headache disorders; CGRP antibodies; gepants; ditans; triptans; precision medicine; neuromodulation; comorbidities; disability burden; pediatric migraine; ICHD-3 classification; neurotransmitters; preventive therapy; translational headache research
(This special issue belongs to the Section Clinical Neurology)
New Insights in Cognitive Aging and Mild Cognitive Impairment submission deadline 25 Feb 2027 | 5 articles | Viewed by 5368 | Submission Open
Keywords: cognitive aging; mild cognitive impairment; normative aging; neuropsychological assessment; diagnosis; gerontology; prevention; intervention; multidisciplinary approach; measurement
(This special issue belongs to the Section Geriatric Medicine)
Headache Disorders: New Advances in Management and Treatment Strategies: 2nd Edition submission deadline 25 Feb 2027 | 3 articles | Viewed by 5311 | Submission Open
Keywords: headache; migraine; cluster headache; tension-type headache; post-traumatic headache; calcitonin gene-related peptide; monoclonal antibodies; preventive therapy; acute treatment; pathophysiology; neuromodulation; pain management; drug development; gepants; ditan
(This special issue belongs to the Section Clinical Neurology)
Clinical Diagnosis and Surgical Strategies Update on Ear Disorders: 2nd Edition submission deadline 25 Feb 2027 | 5 articles | Viewed by 5198 | Submission Open
Keywords: middle ear; inner ear; endoscopic ear surgery; cholesteatoma; Menière’s disease; hearing loss; robotic surgery; oto-sclerosis
(This special issue belongs to the Section Otolaryngology)
Innovative Aspects in Dental Implantology and Related Clinical Research (Second Edition) submission deadline 25 Feb 2027 | 3 articles | Viewed by 4940 | Submission Open
Keywords: dental implants; implantology; bone regeneration; implant-supported prosthesis; zygomatic implants; reconstructive surgery; pre-implant surgery; short implants
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Advanced Hepato-Pancreato-Biliary Surgery: Clinical Innovations and Improved Outcomes
edited by Ahmad Mahamid and Riad Haddad
submission deadline 25 Feb 2027 | 3 articles | Viewed by 4516 | Submission Open
Keywords: liver surgery; pancreas surgery; biliary surgery; robotic HPB surgery; single incision surgery; prognostic biomarkers; perioperative clinical care; postoperative complications
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advances in Cardiovascular Rehabilitation: The Central Role of Exercise in Prevention and Care
edited by Massimo Pistono
submission deadline 25 Feb 2027 | 4 articles | Viewed by 4066 | Submission Open
Keywords: cardiac rehabilitation; secondary prevention; physical exercise; cardiovascular health; aerobic exercise; cardio-oncology rehabilitation
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Updates in Cardiovascular Computed Tomography (CT)
edited by
submission deadline 25 Feb 2027 | 2 articles | Viewed by 3986 | Submission Open
Keywords: cardiovascular CT; coronary CTA; plaque imaging; artificial intelligence; low-dose imaging; structural heart disease; cardiac imaging; high-risk plaque; atherosclerosis; coronary artery disease; valve calcification; thrombus detection
(This special issue belongs to the Section Cardiovascular Medicine)
Hospital-Acquired Infections: Evolving Threats and Epidemiological Insights
edited by
submission deadline 25 Feb 2027 | 4 articles | Viewed by 3727 | Submission Open
Keywords: hospital-acquired infections; healthcare-associated infections; antimicrobial resistance; multidrug-resistant organisms (MDRO); infection prevention and control; outbreak investigation; patient safety; healthcare epidemiology
(This special issue belongs to the Section Infectious Diseases)
Geriatric Cardiology: Clinical Advances and Comprehensive Management
edited by
submission deadline 25 Feb 2027 | 2 articles | Viewed by 3007 | Submission Open
Keywords: geriatric assessment; management of cardiovascular disease; cardiovascular health; geriatric cardiology; frailty evaluation and management
(This special issue belongs to the Section Geriatric Medicine)
Endoscopic Therapy in Gastroesophageal Reflux Disease (GERD): Current Evidence, Techniques, and Future Perspectives
edited by Pier Alberto Testoni
submission deadline 25 Feb 2027 | 1 articles | Viewed by 2888 | Submission Open
Keywords: gastroenterology; gastroesophageal reflux disease; GERD; esophageal diseases; endoscopic therapy
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Recent Clinical Advances in Cardiac Rehabilitation: 2nd Edition
edited by
submission deadline 25 Feb 2027 | 2 articles | Viewed by 2480 | Submission Open
Keywords: cardiac rehabilitation; kinesiotherapy; psychological support; lifestyle modifications; myocardial infarction; heart failure
(This special issue belongs to the Section Cardiology)
Advancing Neonatal Seizures and Epilepsy: New Perspectives and Interventions
edited by and Gaetano Cantalupo
submission deadline 25 Feb 2027 | 1 articles | Viewed by 2215 | Submission Open
Keywords: neonatal seizures; neonatal epilepsy; neonatal EEG; automated EEG analysis; neonatal brain monitoring; genetic; precision medicine; genetic epilepsies; genome; exome
(This special issue belongs to the Section Clinical Pediatrics)
Cardiometabolic Disease and Atherosclerosis: Epidemiology, Prevention, Diagnosis, and Clinical Treatment—2nd Edition
edited by and Konstantinos Mourouzis
submission deadline 25 Feb 2027 | 2 articles | Viewed by 2003 | Submission Open
Keywords: atherosclerosis; obesity; cardiometabolic disease; prevention; diabetes mellitus; endothelium; arteriosclerosis; coronary artery disease
(This special issue belongs to the Section Cardiology)
Optimizing Radiotherapy in Clinical Practice: Innovation and Outcomes
edited by , and Joseph Moore
submission deadline 25 Feb 2027 | 2 articles | Viewed by 1655 | Submission Open
Keywords: AI-assisted automated contouring and planning; AI-assisted quality assurance; AI-assisted safety and quality improvement; radiotherapy automation; radiomics; radiotherapy error detection; personalized radiopharmaceutical therapy; theranostics; online adaptive radiotherapy; real-time treatment adaptation; image-guided radiotherapy (IGRT); AI-assisted online adaptation; personalized radiotherapy; cone-beam CT adaptation
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Clinical Updates and Current Challenges in Obstetrical Anesthesia
edited by Michael Froelich
submission deadline 25 Feb 2027 | 1 articles | Viewed by 1636 | Submission Open
Keywords: obstetrical anesthesia; clinical innovation; practice guidelines; neuraxial techniques; enhanced recovery; risk stratification; maternal safety; multimodal analgesia; health systems innovation; global and low-resource care
(This special issue belongs to the Section Obstetrics & Gynecology)
Emerging Trends and Therapeutic Innovations in Corneal and Ocular Surface Disorders
edited by and Špela Štunf Pukl
submission deadline 25 Feb 2027 | 2 articles | Viewed by 1415 | Submission Open
Keywords: corneal diseases; ocular surface disorders; regenerative medicine; stem cell therapy; gene therapy; nanomedicine and targeted drug delivery
(This special issue belongs to the Section Ophthalmology)
Advances in Clinical Practice and Personalized Approaches in Cardiovascular Disease—2nd Edition
edited by Joseph B. Selvanayagam and
submission deadline 25 Feb 2027 | 2 articles | Viewed by 1271 | Submission Open
Keywords: personalized medicine; cardiovascular innovations; cardiac imaging; risk assessment; multimodal imaging; therapeutic strategies; data-driven decision making; clinical outcomes; translational research
(This special issue belongs to the Section Cardiovascular Medicine)
Pediatric Sleep Health: From Pathophysiology to Quality of Life submission deadline 25 Feb 2027 | 1 articles | Viewed by 934 | Submission Open
Keywords: pediatric sleep; sleep disorders; child development; cognition; quality of life; neurodevelopment; pathophysiology; sleep health interventions; academic; sleep-disordered breathing; MRI; neuroscience
(This special issue belongs to the Section Clinical Pediatrics)
Clinical Advancements in Laparoscopic Surgery for Gastrointestinal Diseases
edited by
submission deadline 25 Feb 2027 | 1 articles | Viewed by 703 | Submission Open
Keywords: laparoscopic surgery; minimally invasive surgery; gastrointestinal diseases; colorectal cancer; gastric cancer; robotic surgery; fluorescence imaging; endoscopic-laparoscopic hybrid surgery; surgical oncology; future perspectives
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
The Interplay of Trauma Symptoms and Cognitive Functioning: Clinical Implications
edited by and
submission deadline 25 Feb 2027 | Viewed by 396 | Submission Open
Keywords: trauma; stress; cognitive dysfunction; clinical syndromes; clinical implications
(This special issue belongs to the Section Mental Health)
Surgical Innovations in Pediatric Orthopedics
edited by
submission deadline 25 Feb 2027 | Viewed by 386 | Submission Open
Keywords: pediatric orthopedics; surgical innovation; growth modulation; absorbable implant; 3D printing
(This special issue belongs to the Section Orthopedics)
Advances in Minimally Invasive and Endoscopic Neurosurgery
edited by Shunsuke Shibao
submission deadline 25 Feb 2027 | Viewed by 372 | Submission Open
Keywords: minimally invasive; endoscopic; keyhole; endonasal; transorbital; skull base; complications; surgical outcomes; technical innovations; robotic neurosurgery
(This special issue belongs to the Section Clinical Neurology)
Exercise, Rehabilitation, and Women’s Health: Clinical Perspectives in Sports Medicine
edited by and
submission deadline 25 Feb 2027 | Viewed by 310 | Submission Open
Keywords: women’s health; exercise intervention; rehabilitation; exercise physiology; musculoskeletal health; healthy aging; resistance training; nutrition
(This special issue belongs to the Section Clinical Rehabilitation)
Cancer Prevention and Early Detection: Epidemiological Approaches and Public Health Strategies submission deadline 25 Feb 2027 | Viewed by 303 | Submission Open
Keywords: cancer prevention; cancer screening; risk factors; cancer treatment; health information systems; cancer registry; cancer inequalities
(This special issue belongs to the Section Epidemiology & Public Health)
Pelvic Floor Disorders: Emerging Perspectives on Therapeutic Approaches submission deadline 25 Feb 2027 | Viewed by 166 | Submission Open
Keywords: pelvic floor surgery; laparoscopic approach; quality of life; pelvic organ prolapse surgery; urinary and fecal incontinence; pelvic floor disorders
(This special issue belongs to the Section Obstetrics & Gynecology)
Colorectal Surgery: New Clinical Advances, Challenges and Future Directions
edited by
submission deadline 25 Feb 2027 | Viewed by 100 | Submission Open
Keywords: colon surgery; colorectal surgery; colorectal cancer; IBD surgery; proctology; diverticular disease; diverticulitis; surgical outcomes
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advances in Immunohematology: From Pathophysiology to Tailored Treatments submission deadline 28 Feb 2027 | 1 articles | Viewed by 4496 | Submission Open
Keywords: autoimmune cytopenia; hemophagocytic lymphohistiocytosis; inborn errors of immunity; lymphoproliferative diseases; malignancy; monoclonal antibodies; secondary immunodeficiency; vaccination
(This special issue belongs to the Section Immunology & Rheumatology)
Tumor Microenvironment—Current Status and Therapeutic Targets
edited by
submission deadline 28 Feb 2027 | 2 articles | Viewed by 4077 | Submission Open
Keywords: tumor microenvironment (TME); cancer immunology; immune checkpoint inhibitors; cancer biology; targeted therapies
(This special issue belongs to the Section Oncology)
Emerging Therapies: Clinical Trials and Insights in Psoriasis
edited by and Elżbieta Krajewska-Kułak
submission deadline 28 Feb 2027 | 3 articles | Viewed by 2818 | Submission Open
Keywords: psoriasis; clinical trials; biomarkers; psychodermatology; treatment; modern therapy; individualized therapy
(This special issue belongs to the Section Dermatology)
Clinical Rehabilitation Strategies and Exercise for Stroke Recovery submission deadline 28 Feb 2027 | 4 articles | Viewed by 2732 | Submission Open
Keywords: stroke; stroke rehabilitation; exercise; biomarkers; rehabilitation outcomes
(This special issue belongs to the Section Clinical Rehabilitation)
Allergic and Eosinophilic Diseases: Diagnosis, Treatment and Management (Second Edition)
edited by Aikaterini Detoraki
submission deadline 28 Feb 2027 | 1 articles | Viewed by 2054 | Submission Open
Keywords: allergy; eosinophilic diseases; immunology; clinical immunology; asthma; diagnosis; treatment; management
(This special issue belongs to the Section Immunology & Rheumatology)
Ergonomics and Low Back Pain: Integrative Approaches to Prevention, Assessment and Management submission deadline 28 Feb 2027 | 1 articles | Viewed by 1998 | Submission Open
Keywords: advanced in diagnostic methods; therapeutic innovations; multidisciplinary and personalized care models; prevention and rehabilitation; non-pharmacological strategies; ergonomics; biomechanics
(This special issue belongs to the Section Orthopedics)
Clinical and Epidemiological Aspects of Frailty in Acute Kidney Injury: A Spotlight on Risk Factors, Prevention and Management submission deadline 28 Feb 2027 | 1 articles | Viewed by 414 | Submission Open
Keywords: sarcopenia; AKI; frailty; amyloidosis; nutrition; epidemiology
(This special issue belongs to the Section Nephrology & Urology)
Modern Challenges in Pediatric Endocrinology: From Growth Disorders to Metabolic Dysregulation
edited by Katarzyna A. Majewska and Piotr Fichna
submission deadline 2 Mar 2027 | 2 articles | Viewed by 2501 | Submission Open
Keywords: growth hormone deficiency; growth hormone therapy; short stature; obesity; obesity complications; obesity treatment; insulin resistance; prediabetes; type 1 diabetes; type 2 diabetes; hypothyroidism; hyperthyroidism; autoimmune thyroiditis; puberty disorders
(This special issue belongs to the Section Clinical Pediatrics)
Cerebrovascular Disease: Symptoms, Diagnosis and Current Treatment—Second Edition
edited by Alba Scerrati and Giorgio Mantovani
submission deadline 5 Mar 2027 | 3 articles | Viewed by 3649 | Submission Open
Keywords: ischemic stroke; cerebral aneurysms; cerebral vascular malformation; cerebral venous disease; cerebral venous thrombosis
(This special issue belongs to the Section Clinical Neurology)
Integrating Artificial Intelligence into Plastic, Reconstructive, and Aesthetic Surgery: Innovations, Challenges, and Clinical Application submission deadline 5 Mar 2027 | 2 articles | Viewed by 3387 | Submission Open
Keywords: plastic; reconstructive; aesthetic surgery; artificial intelligence; AI in plastic surgery
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
The Atrial Fibrillation–Heart Failure Interconnection: Challenges and Innovations in Diagnosis and Treatment submission deadline 5 Mar 2027 | 1 articles | Viewed by 2017 | Submission Open
Keywords: atrial fibrillation; catheter ablation; ventricular dysfunction; myocardial remodeling; diastolic dysfunction; biomarkers; anti-arrhythmia agents; risk assessment; artificial intelligence; telemedicine
(This special issue belongs to the Section Cardiovascular Medicine)
Emerging Biomarkers and Novel Diagnostic Tools in Respiratory Diseases: From Bench to Bedside submission deadline 10 Mar 2027 | 4 articles | Viewed by 3033 | Submission Open
Keywords: respiratory diseases; biomarkers; non-invasive approaches; novel diagnostic tests; precision medicine; personalized therapy; disease phenotyping; diagnostic tools; functional biomarkers; imaging biomarkers; molecular biomarkers
(This special issue belongs to the Section Respiratory Medicine)
Gynecologic Cancers: Integrating Established Standards and Innovative Approaches
edited by Radu Vladareanu and Liviu Bilteanu
submission deadline 10 Mar 2027 | 2 articles | Viewed by 2851 | Submission Open
Keywords: gynecological cancers; cervical cancer; ovarian cancer; endometrial cancer; vulvar and vaginal tumors; uterine sarcoma; fertility preservation; robotic surgery; image-guided radiotherapy (IGRT); brachytherapy; proton and FLASH radiotherapy; immunotherapy; radiomics; artificial intelligence; digital twin; multimodal treatment; survivorship and quality of life
(This special issue belongs to the Section Oncology)
Echocardiography in Clinical Cardiac Imaging: Advances and Emerging Applications
edited by
submission deadline 10 Mar 2027 | 2 articles | Viewed by 2752 | Submission Open
Keywords: echocardiography; cardiac Imaging; speckle-tracking echocardiography; artificial intelligence; myocardial function; valvular heart disease; precision cardiology
(This special issue belongs to the Section Cardiology)
Radiation Therapy: Recent Trends and Future Perspectives
edited by , and Jae-won Park
submission deadline 10 Mar 2027 | 1 articles | Viewed by 905 | Submission Open
Keywords: breast reconstruction & PMRT; SBRT in oligometastatic cancer; metastasis-directed therapy; trends in modern radiotherapy techniques; palliative radiotherapy optimization; quality of life (QoL) in oncology; precision radiation oncology; artificial intelligence in radiotherapy
(This special issue belongs to the Section Oncology)
Acute Myocardial Infarction: Diagnosis and Novel Treatment Opportunities
edited by and Flavio Giuseppe Biccirè
submission deadline 10 Mar 2027 | 1 articles | Viewed by 803 | Submission Open
Keywords: acute myocardial infarction; atherosclerosis; percutaneous coronary intervention; atherothrombosis; inflammation; dyslipidemia; lipid-lowering therapy
(This special issue belongs to the Section Cardiology)
Shoulder and Elbow Diseases: Advances in Diagnosis, Treatment and Rehabilitation
edited by , and Joseph A. Abboud
submission deadline 10 Mar 2027 | 1 articles | Viewed by 493 | Submission Open
Keywords: shoulder; elbow; rotator cuff; arthritis; shoulder instability; arthroscopy; arthroplasty; tendinopathy; orthobiologics; rehabilitation; imaging
(This special issue belongs to the Section Orthopedics)
Open, Hybrid and Endovascular Repair of Visceral Artery Aneurysms: State of the Art and Clinical Perspectives
edited by , Francesco Squizzato and Vincenzo Vento
submission deadline 10 Mar 2027 | Viewed by 326 | Submission Open
Keywords: visceral artery aneurysms; endovascular treatment; open surgical repair; hybrid approach; covered stents; end-organ ischemia; long-term durability; patient selection
(This special issue belongs to the Section Vascular Medicine)
Contemporary Clinical Treatment and Rehabilitation of Scoliosis
edited by and Zbigniew Śliwiński
submission deadline 10 Mar 2027 | Viewed by 162 | Submission Open
Keywords: scoliosis; adolescent idiopathic scoliosis; spinal deformity; conservative treatment; physiotherapy; rehabilitation; physi-otherapeutic scoliosis-specific exercises (PSSE); postural control; spinal alignment; biomechanics; neuromuscular reha-bilitation; surface topography; raster stereography; gait analysis; musculoskeletal disorders
(This special issue belongs to the Section Orthopedics)
Artificial Intelligence and Eye Disease: 2nd Edition submission deadline 10 Mar 2027 | Viewed by 150 | Submission Open
Keywords: artificial intelligence; machine learning; deep learning; ophthalmology; eye disease; eye disorders
(This special issue belongs to the Section Ophthalmology)
Clinical Diagnosis and Management of Attention-Deficit/Hyperactivity Disorder (ADHD) submission deadline 10 Mar 2027 | Viewed by 115 | Submission Open
Keywords: ADHD; randomized controlled trials; clinical research; neurodevelopmental disorders; cognitive function; prefrontal cortex; diagnostic methods; therapeutic interventions; evidence-based medicine
(This special issue belongs to the Section Mental Health)
Robotic Surgery in Urologic Diseases: Multidisciplinary Research and Clinical Practice
edited by Donato Cannoletta
submission deadline 10 Mar 2027 | Viewed by 114 | Submission Open
Keywords: robotic surgery; urological surgery; robotic platforms
(This special issue belongs to the Section Nephrology & Urology)
Recent Clinical Advances in Percutaneous Coronary Intervention
edited by and Luke Pickup
submission deadline 15 Mar 2027 | 2 articles | Viewed by 7064 | Submission Open
Keywords: complex PCI; calcium modification; left main stem; stent; coronary artery disease; atherectomy; mechanical circula-tory support device; Impella; DCB; intra-coronary imaging; IVUS; OCT
(This special issue belongs to the Section Cardiology)
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