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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Imaging and Molecular Biomarkers: The New Approach to Degenerative Retinal Diseases

edited by

Giulia Midena

and

Elisabetta Pilotto

submission deadline 28 Jun 2026 | 2 articles | Viewed by 1272 | Submission Open

Keywords: ophthalmology; degenerative retinal diseases; imaging biomarkers; multimodal imaging; OCT; OCT angiography; molecular biomarkers; precision medicine; translational ophthalmic research

(This special issue belongs to the Section Ophthalmology)

Youth Sports Injuries: From Prevalence to Prevention

edited by Swarup Mukherjee and

Gregory C. Bogdanis

submission deadline 30 Jun 2026 | 4 articles | Viewed by 12816 | Submission Open

Keywords: youth sports injuries; musculoskeletal injuries; injury prevention; sport safety; youth athletes

(This special issue belongs to the Section Sports Medicine)

The Atrial Fibrillation–Heart Failure Interconnection: Challenges and Innovations in Diagnosis and Treatment

edited by

Roberto De Ponti

and

Michele Golino

submission deadline 30 Jun 2026 | Viewed by 171 | Submission Open

Keywords: atrial fibrillation; catheter ablation; ventricular dysfunction; myocardial remodeling; diastolic dysfunction; biomarkers; anti-arrhythmia agents; risk assessment; artificial intelligence; telemedicine

(This special issue belongs to the Section Cardiovascular Medicine)

Ergonomics and Low Back Pain: Integrative Approaches to Prevention, Assessment and Management

edited by

Janan Abbas

and

Deborah Alperovitch

submission deadline 30 Jun 2026 | Viewed by 90 | Submission Open

Keywords: advanced in diagnostic methods; therapeutic innovations; multidisciplinary and personalized care models; prevention and rehabilitation; non-pharmacological strategies; ergonomics; biomechanics

(This special issue belongs to the Section Orthopedics)

New Clinical Insights into Acute Respiratory Failure

edited by

Christophe Guervilly

submission deadline 30 Jun 2026 | Viewed by 66 | Submission Open

Keywords: acute respiratory failure; pathophysiology; advances respiratory monitoring; respiratory support strategies; respiratory mechanics; mechanical ventilation; respiratory drive; patient-ventilator asynchrony

(This special issue belongs to the Section Intensive Care)

Integrating a One Health Approach into Antimicrobial Stewardship and Shared Care in Wound Management

edited by Joanna F. Blackburn

submission deadline 30 Jun 2026 | Viewed by 57 | Submission Open

Keywords: antimicrobial stewardship; antimicrobial resistance; one health; shared care; wound care; wound care management; chronic wound care; acute wound care; digital health; wound diagnostics; antimicrobials; antibiotics

(This special issue belongs to the Section Dermatology)

Clinical Advances in Aortic Disease and Revascularization: 2nd Edition

edited by Andrej Udelnow

submission deadline 30 Jun 2026 | Viewed by 49 | Submission Open

Keywords: aortic disease; aortic aneurysm; endovascular aortic repair; atherosclerosis; aortic dissections; overall survival; quality of life; intravascular ultrasound

(This special issue belongs to the Section Vascular Medicine)

Robotic-Assisted Hepato-Pancreato-Biliary (HPB) Surgery: Advances and Clinical Perspectives

edited by

Michele Tedeschi

and Riccardo Memeo

submission deadline 30 Jun 2026 | Viewed by 28 | Submission Open

Keywords: liver surgery; pancreatic surgery; HPB surgery; robotic surgery; robotic systems; advances in HPB surgery

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Advances in Anterior Cruciate Ligament Injury Treatment

edited by Goran Vrgoč

submission deadline 1 Jul 2026 | Viewed by 40 | Submission Open

Keywords: anterior cruciate ligament (ACL) injury; ACL reconstruction techniques; nonoperative ACL treatment; ACL graft; knee biomechanics; return-to-sport assessment; ACL rehabilitation; neuromuscular and proprioceptive training; athletic injuries; performance-enhancing substances; reinjury prevention; psychological readiness; ACL performance testing; osteoarthritis risk

(This special issue belongs to the Section Orthopedics)

Modern Challenges in Pediatric Endocrinology: From Growth Disorders to Metabolic Dysregulation

edited by Katarzyna A. Majewska and Piotr Fichna

submission deadline 2 Jul 2026 | Viewed by 94 | Submission Open

Keywords: growth hormone deficiency; growth hormone therapy; short stature; obesity; obesity complications; obesity treatment; insulin resistance; prediabetes; type 1 diabetes; type 2 diabetes; hypothyroidism; hyperthyroidism; autoimmune thyroiditis; puberty disorders

(This special issue belongs to the Section Clinical Pediatrics)

Clinical Management for Coronary Artery Disease and Revascularization

edited by Mohammad Reza Movahed

submission deadline 10 Jul 2026 | 3 articles | Viewed by 4864 | Submission Open

Keywords: coronary artery disease; coronary syndrome; stenting; revascularization; cardiovascular

(This special issue belongs to the Section Cardiovascular Medicine)

New Insights into Skin Tumors: From Pathogenesis to Therapy

edited by Loredana Ungureanu and Simona C. Şenilǎ

submission deadline 10 Jul 2026 | 3 articles | Viewed by 3067 | Submission Open

Keywords: skin tumors; pathogenesis; diagnosis; personalized medicine; therapeutic strategies; dermato-oncology

(This special issue belongs to the Section Dermatology)

Visualizing Cardiac Function: Advances in Modern Imaging Diagnostics

edited by Dafni Charisopoulou and

Michael Henein

submission deadline 10 Jul 2026 | 1 articles | Viewed by 327 | Submission Open

Keywords: cardiac imaging; echocardiography; coronary artery disease; valve disease; heart failure

(This special issue belongs to the Section Cardiology)

Gynecologic Cancers: Integrating Established Standards and Innovative Approaches

edited by Radu Vladareanu and Liviu Bilteanu

submission deadline 10 Jul 2026 | Viewed by 71 | Submission Open

Keywords: gynecological cancers; cervical cancer; ovarian cancer; endometrial cancer; vulvar and vaginal tumors; uterine sarcoma; fertility preservation; robotic surgery; image-guided radiotherapy (IGRT); brachytherapy; proton and FLASH radiotherapy; immunotherapy; radiomics; artificial intelligence; digital twin; multimodal treatment; survivorship and quality of life

(This special issue belongs to the Section Oncology)

Endoscopic Therapy in Gastroesophageal Reflux Disease (GERD): Current Evidence, Techniques, and Future Perspectives

edited by Pier Alberto Testoni

submission deadline 10 Jul 2026 | Viewed by 58 | Submission Open

Keywords: gastroenterology; gastroesophageal reflux disease; GERD; esophageal diseases; endoscopic therapy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Emerging Biomarkers and Novel Diagnostic Tools in Respiratory Diseases: From Bench to Bedside

edited by

Silvano Dragonieri

and

Andras Bikov

submission deadline 10 Jul 2026 | Viewed by 56 | Submission Open

Keywords: respiratory diseases; biomarkers; non-invasive approaches; novel diagnostic tests; precision medicine; personalized therapy; disease phenotyping; diagnostic tools; functional biomarkers; imaging biomarkers; molecular biomarkers

(This special issue belongs to the Section Respiratory Medicine)

Open, Hybrid and Endovascular Repair of Visceral Artery Aneurysms: State of the Art and Clinical Perspectives

edited by

Andrea Xodo

, Francesco Squizzato and Vincenzo Vento

submission deadline 10 Jul 2026 | Viewed by 35 | Submission Open

Keywords: visceral artery aneurysms; endovascular treatment; open surgical repair; hybrid approach; covered stents; end-organ ischemia; long-term durability; patient selection

(This special issue belongs to the Section Vascular Medicine)

Personalized Medicine: Future Perspectives on Personalized Oral and Maxillofacial Surgery

edited by

Cosmin Ioan Faur

, Rareș Calin Roman and Mihaela Carmen Hedeşiu

submission deadline 15 Jul 2026 | 1 articles | Viewed by 887 | Submission Open

Keywords: head and neck surgery; head and neck oncology; head and neck reconstructions; personalized medicine; artificial intelligence; head and neck trauma; integrative medicine

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Updates on Epilepsy Researches

edited by

Guillermo Estivill-Torrús

submission deadline 15 Jul 2026 | Viewed by 151 | Submission Open

Keywords: epilepsy; autoimmune epilepsy; neural autoantibodies; seizure disorders; experimental epilepsy models; animal studies; neuronal excitability; immunotherapy; predictive scoring systems; epilepsy biomarkers

(This special issue belongs to the Section Clinical Neurology)

Total Hip Arthroplasty Today: Trends, Challenges, and Future Directions

edited by

Seung-Jae Lim

submission deadline 15 Jul 2026 | Viewed by 116 | Submission Open

Keywords: complex hip arthroplasty; surgical technique; innovative implant; new technology; robotic surgery; navigation surgery; artificial intelligence; complications; periprosthetic joint infection; periprosthetic fracture; dislocation

(This special issue belongs to the Section Orthopedics)

Aortic Dissection: Current Trends, Complexities, and Future Directions

edited by Aung Ye Oo

submission deadline 15 Jul 2026 | Viewed by 90 | Submission Open

Keywords: aortic dissection; aortic surgery; hybrid and endovascular repair; diagnostic delay; systems of care; patient safety; biomarkers and imaging; postoperative outcomes; multidisciplinary collaboration in aortic disease management

(This special issue belongs to the Section Cardiovascular Medicine)

Approaches to Prevention and Management of Postoperative Complications in Minimally Invasive Surgery

edited by Shingo Tsujinaka

submission deadline 15 Jul 2026 | Viewed by 78 | Submission Open

Keywords: minimally invasive surgery; postoperative complications; preventive measures; risk assessment; surgical techniques; patient optimization; complication management; surgical outcomes; patient satisfaction; patient-reported outcomes

(This special issue belongs to the Section General Surgery)

Fertility Challenges: Modern Management Strategies and Assisted Reproductive Technologies

edited by

Luigi Carbone

submission deadline 15 Jul 2026 | Viewed by 70 | Submission Open

Keywords: infertility; assisted reproductive technologies (ARTs); ovarian reserve; antral follicle count (AFC); anti-mullerian hormone (AMH); fertility preservation; IVF pregnancy; ovarian stimulation; embryo selection

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Measuring Recovery After Arthroplasty: Optimal Tools and Timing of Outcome Assessment

edited by

Nicholas David Clement

submission deadline 15 Jul 2026 | Viewed by 60 | Submission Open

Keywords: arthroplasty; hip; knee; recovery; outcomes; assessment

(This special issue belongs to the Section Orthopedics)

Neurosurgery Advancements: Techniques and Patient Outcomes

edited by Vianney Gilard

submission deadline 15 Jul 2026 | Viewed by 60 | Submission Open

Keywords: neurosurgery; minimally invasive surgery; endoscopic spine surgery; intraoperative imaging; neuro-oncology; functional neurosurgery; neurovascular surgery; patient outcomes

(This special issue belongs to the Section Clinical Neurology)

Glaucoma: Advances in Diagnosis, Management, and Vision Preservation

edited by

Masaki Tanito

and

Takuhei Shoji

submission deadline 15 Jul 2026 | Viewed by 57 | Submission Open

Keywords: glaucoma diagnosis; OCT and OCT angiography; laser therapies (SLT; micropulse; cyclophotocoagulation; etc.); minimally invasive glaucoma surgery (MIGS); long-tube devices; artificial intelligence and imaging; pharmacological therapy; visual field and retinal ganglion cell function

(This special issue belongs to the Section Ophthalmology)

Understanding Dermatitis: Symptoms and Effective Treatment Options

edited by

Emi Sato

and Shinichi Imafuku

submission deadline 15 Jul 2026 | Viewed by 55 | Submission Open

Keywords: dermatitis; atopic dermatitis; psoriasis; prurigo; JAK inhibitors; real world data

(This special issue belongs to the Section Dermatology)

Multiple Sclerosis: Current Diagnosis, Treatment, and Future Options

edited by Przemysław Puz,

Nikolaos Grigoriadis

and

Eduardo Agüera-Morales

submission deadline 15 Jul 2026 | Viewed by 51 | Submission Open

Keywords: multiple sclerosis; magnetic resonance imaging (MRI); remyelination; biomarkers; neuroprotection

(This special issue belongs to the Section Clinical Neurology)

Current Challenges and Advancements in Stroke Prevention and Cerebrovascular Disorders

edited by

Ewelina Bak

and Sylwia Krzemińska

submission deadline 15 Jul 2026 | Viewed by 49 | Submission Open

Keywords: risk factors; secondary prevention; health education; health behaviors

(This special issue belongs to the Section Clinical Rehabilitation)

Novel Therapeutic Strategies in Rheumatoid Arthritis

edited by Mislav Radić

submission deadline 15 Jul 2026 | Viewed by 46 | Submission Open

Keywords: rheumatoid arthritis; targeted therapies; biological agents; small molecule inhibitors; biomarkers; personalized medicine; treatment response

(This special issue belongs to the Section Immunology & Rheumatology)

Cardiac Arrhythmias: Current Status and Future Directions

edited by

Jackson J. Liang

submission deadline 20 Jul 2026 | 1 articles | Viewed by 6570 | Submission Open

Keywords: ventricular tachycardia; atrial fibrillation; catheter ablation; novel therapies; complex arrhythmias

(This special issue belongs to the Section Cardiology)

Sarcopenia, Musculoskeletal, and Neuromuscular Disorders: Physical Therapy and Rehabilitation Perspectives

edited by

Do-youn Lee

and

Myoung-Kwon Kim

submission deadline 20 Jul 2026 | 1 articles | Viewed by 864 | Submission Open

Keywords: sarcopenia; musculoskeletal diseases; neuromuscular disorders; muscle mass; low back pain; neck pain; gait and balance; physical therapy; rehabilitation medicine

(This special issue belongs to the Section Clinical Rehabilitation)

Clinical Updates in Fractures: Orthopedics, Trauma Surgery, and Rehabilitation

edited by

Rahul Vaidya

submission deadline 20 Jul 2026 | 1 articles | Viewed by 776 | Submission Open

Keywords: orthopedic surgery; global orthopedic health; surgical techniques; outreach; inreach; artificial intelligence; robotics; outcome measures

(This special issue belongs to the Section Orthopedics)

Paradigms, Advances and Future Directions in Oral Medicine

edited by

Pia Lopez-Jornet

submission deadline 20 Jul 2026 | 1 articles | Viewed by 609 | Submission Open

Keywords: oral medicine; oral potentially malignant disorders; leukoplakia; oral lichen planus; orofacial pain; biopsy and liquid biopsy; biomarkers

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Integrating Artificial Intelligence into Plastic, Reconstructive, and Aesthetic Surgery: Innovations, Challenges, and Clinical Application

edited by

Roberto Cuomo

and

Gianluca Marcaccini

submission deadline 20 Jul 2026 | 1 articles | Viewed by 454 | Submission Open

Keywords: plastic; reconstructive; aesthetic surgery; artificial intelligence; AI in plastic surgery

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

State of the Art in Spinal Cord Injuries: Clinical Rehabilitation and Management

edited by

Valerio Pisani

submission deadline 20 Jul 2026 | 1 articles | Viewed by 443 | Submission Open

Keywords: neurorehabilitation; assistive technologies; neuroplasticity; neuromodulation; spinal cord injury

(This special issue belongs to the Section Clinical Rehabilitation)

Minimally Invasive Spine Surgery: Evidence, Advances and Controversies

edited by

Miltiadis Georgiopoulos

, Constantine Constantoyannis,

Mark A. MacLean

and Oliver Lasry

submission deadline 20 Jul 2026 | Viewed by 246 | Submission Open

Keywords: spine surgery; minimally invasive; MIS; MISS; endoscopic; tubular; fusion; laminectomy; discectomy; decompression; percutaneous; robotic; robotic-assisted; navigation; augmented-reality

(This special issue belongs to the Section Clinical Neurology)

Spine Surgery: Clinical Advances and Practice Updates

edited by

Junho Song

submission deadline 20 Jul 2026 | 1 articles | Viewed by 229 | Submission Open

Keywords: spine surgery; minimally invasive spine surgery; endoscopic spine surgery; robotics; artificial intelligence; spinal deformity; scoliosis; spinal trauma

(This special issue belongs to the Section Orthopedics)

Advances in Clinical Management of Temporomandibular Joint Diseases

edited by

João Luiz Monteiro

submission deadline 20 Jul 2026 | Viewed by 185 | Submission Open

Keywords: minimally invasive surgical procedure; artificial intelligence; temporomandibular joint disorders; temporomandibular disorders; temporomandibular joint

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

New Insights in Trauma and Emergency Surgery

edited by Kai Oliver Jensen and Valentin Neuhaus

submission deadline 20 Jul 2026 | Viewed by 176 | Submission Open

Keywords: trauma and emergency surgery; multiple trauma; orthopedic trauma; surgery; concepts in trauma

(This special issue belongs to the Section Emergency Medicine)

Current Challenges in Adult Congenital Heart Diseases

edited by

Agata Bielecka-Dabrowa

submission deadline 20 Jul 2026 | Viewed by 175 | Submission Open

Keywords: adult congenital heart disease; quality of life; pregnancy in congenital heart disease; heart failure; arrhythmia; septal defect; congenital valve stenosis; coarctation of the Aorta; Fontan circulation; Tetralogy of Fallot

(This special issue belongs to the Section Cardiology)

Pre-Hospital and In-Hospital Emergency Care Research

edited by

Marcus Eng Hock Ong

Fahad Javaid Siddiqui

and Yohei Okada

submission deadline 20 Jul 2026 | Viewed by 148 | Submission Open

Keywords: pre-hospital; in-hospital; emergency care; emergency medical services; acute care

(This special issue belongs to the Section Emergency Medicine)

Current Concepts in Melanoma: Innovations in Early Detection, Prognosis and Management

edited by Babar Khan Rao

submission deadline 20 Jul 2026 | Viewed by 131 | Submission Open

Keywords: melanoma; early detection; non-invasive diagnostic innovations; artificial intelligence-assisted diagnosis; melanoma management

(This special issue belongs to the Section Dermatology)

Exercise for Healthy Aging: Clinical Physiology, Functional Outcomes, and Implications for Clinical Practice

edited by

Jerónimo Aragón-Vela

and

Rafael A. Casuso

submission deadline 20 Jul 2026 | Viewed by 128 | Submission Open

Keywords: exercise; healthy aging; functional independence; mitochondrial adaptations; physical activity interventions; neuromuscular function; cardiorespiratory fitness; metabolic health; biomarkers of aging

(This special issue belongs to the Section Sports Medicine)

Pneumonia: From Diagnosis to Treatment

edited by

Marie Carmen Valenza

Laura López-López

and

María Granados Santiago

submission deadline 20 Jul 2026 | Viewed by 98 | Submission Open

Keywords: pneumonia; diagnosis; treatment; multidisciplinary care; pulmonary rehabilitation

(This special issue belongs to the Section Respiratory Medicine)

Clinical Application of Digital Transformation in Ophthalmology

edited by

Eisuke Shimizu

submission deadline 20 Jul 2026 | Viewed by 98 | Submission Open

Keywords: clinical application; ocular diseases; artificial intelligence (AI); machine learning/ deep learning; smart ophthalmology

(This special issue belongs to the Section Ophthalmology)

Cataract and Refractive Surgery, and Intraocular Lens (IOL) Implantation: Advancing Diagnosis and Management

edited by Olga Reitblat

submission deadline 20 Jul 2026 | Viewed by 92 | Submission Open

Keywords: cataract surgery; premium intraocular lenses (IOLs); IOL power calculation; visual outcomes; refractive cataract surgery; multifocal IOL; extended depth of focus (EDOF) IOL; toric IOL; full range; vision IOL; biometry

(This special issue belongs to the Section Ophthalmology)

Novel Research in Cardiovascular Imaging

edited by Stanciu Silviu and

Lucia Agoston-Coldea

submission deadline 20 Jul 2026 | Viewed by 90 | Submission Open

Keywords: echocardiography; cardiac CT; CMR; nuclear medicine; artificial intelligence

(This special issue belongs to the Section Cardiovascular Medicine)

Thoracic Surgery Today: Innovations, Challenges, and Future Perspectives

edited by Jeffrey B. Velotta and

Ory Wiesel

submission deadline 20 Jul 2026 | Viewed by 88 | Submission Open

Keywords: thoracic surgery; minimally invasive thoracic surgery; innovation; esophageal surgery; robotic-assisted thoracic surgery; lung cancer; advanced techniques; thoracic surgical oncology; mediastinal surgery; mesothelioma surgery

(This special issue belongs to the Section General Surgery)

Orthodontic Treatment in Clinical Practice: Strategies for Achieving Optimal Outcomes

edited by Adith Venugopal

submission deadline 20 Jul 2026 | Viewed by 86 | Submission Open

Keywords: orthodontics; biomechanics; tooth movement; bone remodeling; malocclusions; smile

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Displaying special issue 1301-1350 on page 27 of 31.

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