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Understanding Dermatitis: Symptoms and Effective Treatment Options

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dermatology".

Deadline for manuscript submissions: 15 July 2026 | Viewed by 3183

Special Issue Editors

Department of Dermatology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
Interests: dermatology; skin; dermatitis; pruritus; atopic dermatitis; inflammatory skin disease; biologics; JAK-ihibitors

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Guest Editor
Department of Dermatology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
Interests: dermatology; dermatitis; pruritus; atopic dermatitis; inflammatory skin disease

Special Issue Information

Dear Colleagues,

Dermatitis refers to a broad group of inflammatory skin diseases with diverse etiologies and immunological characteristics, including atopic dermatitis, psoriasis, contact dermatitis, seborrheic dermatitis, and prurigo. Recent advances in molecular dermatology have elucidated complex networks involving IL-4, IL-13, IL-17, IL-23, JAK-STAT, and the Aryl Hydrocarbon Receptor (AhR) pathways, which are now major therapeutic targets for biologics and small molecule inhibitors. While these groundbreaking advances have significantly improved clinical outcomes, the reasons why specific agents demonstrate varying efficacy across disease subtypes and patient populations remain unclear. This Special Issue, “Understanding Dermatitis: Symptoms and Effective Treatment Options,” aims to provide an integrated understanding of disease mechanisms, clinical phenotypes, and treatment responsiveness across various forms of dermatitis. We welcome submissions on biomarkers, comorbidities, and real-world data to advance precision medicine and improve patient care in inflammatory skin diseases. Contributions may include original articles and reviews.

Dr. Emi Sato
Prof. Dr. Shinichi Imafuku
Guest Editors

Manuscript Submission Information

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Keywords

  • dermatitis
  • atopic dermatitis
  • psoriasis
  • prurigo
  • JAK inhibitors
  • real world data

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Published Papers (1 paper)

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Research

14 pages, 1288 KB  
Article
Older Patients with Atopic Dermatitis Show More Pronounced Early Clinical Improvement with Tralokinumab: A Single-Center Retrospective Real-World Study
by Emi Sato, Naoko Obonai, Monji Koga, Yoshitsugu Sibayama and Shinichi Imafuku
J. Clin. Med. 2026, 15(3), 1117; https://doi.org/10.3390/jcm15031117 - 30 Jan 2026
Cited by 1 | Viewed by 720
Abstract
Background/Objective: Tralokinumab, a monoclonal antibody targeting interleukin-13, is an effective treatment for atopic dermatitis (AD). However, real-world data on age-related differences in clinical responses, particularly among older patients, remain limited. We compared early improvements in pruritus and skin lesions, as well as [...] Read more.
Background/Objective: Tralokinumab, a monoclonal antibody targeting interleukin-13, is an effective treatment for atopic dermatitis (AD). However, real-world data on age-related differences in clinical responses, particularly among older patients, remain limited. We compared early improvements in pruritus and skin lesions, as well as effectiveness, safety, and treatment persistence of tralokinumab, between older patients aged ≥ 70 and <70 years in real-world clinical practice. Methods: This single-center retrospective study included 43 patients with AD who initiated tralokinumab. Patients who discontinued treatment within 3 months, lacked a 3-month evaluation, or had a baseline Eczema Area and Severity Index (EASI) score < 16 were excluded, leaving 33 patients for effectiveness analyses. Patients were stratified by age (≥70 vs. <70 years). Outcomes at 3 months included pruritus severity assessed by the Peak Pruritus Numerical Rating Scale (PP-NRS), eczema severity assessed by the EASI, and response rates (PP-NRS4 and EASI75). Adverse events and reasons for treatment discontinuation were evaluated in all patients. Results: At 3 months, both age groups showed improvement in pruritus and skin lesions. Patients aged ≥ 70 years demonstrated more pronounced early improvement, with a median PP-NRS of 1 (interquartile range, 0–3), a PP-NRS4 response rate of 89.5%, and an EASI75 response rate of 84.2%. Treatment continuation rates did not differ significantly between age groups, indicating comparable tolerability. Conclusions: Tralokinumab was effective and well tolerated in both age groups, with older patients experiencing earlier and more pronounced clinical improvement. These findings suggest that tralokinumab may be effective in elderly patients with atopic dermatitis. These results may suggest tralokinumab as an effective therapy for elderly patients with atopic dermatitis. Validation using larger prospective studies is needed. Full article
(This article belongs to the Special Issue Understanding Dermatitis: Symptoms and Effective Treatment Options)
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