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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Epilepsy and Cerebrovascular Disorders
edited by
submission deadline 25 May 2026 | Viewed by 63 | Submission Open
Keywords: epilepsy; cerebrovascular disorders; stroke; post-stroke epilepsy; neuroinflammation; neuroimaging; electroenceph-alography; biomarkers; antiepileptic treatment; translational neuroscience
(This special issue belongs to the Section Clinical Neurology)
Advances in Kidney Transplantation: 2nd Edition
edited by Pedro Ruiz-Esteban, Domingo Hernández and Veronica López
submission deadline 25 May 2026 | Viewed by 52 | Submission Open
Keywords: kidney transplant; acute rejection; biomarkers; artificial intelligence; post-transplant complications; graft survival
(This special issue belongs to the Section Nephrology & Urology)
Clinical Advances in Management of Urologic Diseases
edited by Francesco Pio Bizzarri and Calogero Casà
submission deadline 25 May 2026 | Viewed by 48 | Submission Open
Keywords: prostate cancer; bladder cancer; kidney cancer; uro-oncology; radiotherapy
(This special issue belongs to the Section Nephrology & Urology)
Advancements in Anterior Cruciate Ligament Injury: From Diagnosis to the Return-to-Sports: 2nd Edition
edited by Alexandre Hardy and Nicolas Bouguennec
submission deadline 28 May 2026 | 3 articles | Viewed by 2714 | Submission Open
Keywords: anterior cruciate ligament reconstruction (ACLR); timing of ACLR; ramp lesion; meniscal lesion; lateral extra-articular procedure
(This special issue belongs to the Section Sports Medicine)
Novel Treatments for Vestibular Migraine
edited by
submission deadline 28 May 2026 | Viewed by 280 | Submission Open
Keywords: neuromodulation therapy; sympathetic nerve stimulation; CGRP-targeted therapy; dietary interventions; elimination diets; ketogenic diet; low-glycemic index diet; nutritional supplements; pathophysiology of vestibular migraine; clinical adoption of VM therapies
(This special issue belongs to the Section Otolaryngology)
Innovations in Thoracic Surgery and Disease Management: Integrating Genomics, Technology, and Multidisciplinary Care submission deadline 28 May 2026 | Viewed by 275 | Submission Open
Keywords: thoracic surgery; thoracic disease; genomic medicine; artificial intelligence; advanced imaging; multidisciplinary care; minimally invasive surgery; robotic surgery; precision medicine
(This special issue belongs to the Section Respiratory Medicine)
Cerebrovascular Disease: Symptoms, Diagnosis and Current Treatment—Second Edition
edited by Alba Scerrati and Giorgio Mantovani
submission deadline 28 May 2026 | Viewed by 87 | Submission Open
Keywords: ischemic stroke; cerebral aneurysms; cerebral vascular malformation; cerebral venous disease; cerebral venous thrombosis
(This special issue belongs to the Section Clinical Neurology)
Spine Surgery Innovations: Treatments and Technologies
edited by and Tomoyuki Asada
submission deadline 29 May 2026 | Viewed by 427 | Submission Open
Keywords: AI; robotics; navigation; muscle preservation; minimally invasive surgery; motion preservation; alignment targets; implant materials; bone growth factors; custom-made implants
(This special issue belongs to the Section Orthopedics)
Pediatric Hearing Loss: Advances in Early Detection, Intervention and Family-Centered Care submission deadline 30 May 2026 | Viewed by 64 | Submission Open
Keywords: pediatric hearing loss; early intervention; early identification of language and communication disorders; develop-mental language disorders; predictors of outcomes; newborn hearing screening; pediatric audiology
(This special issue belongs to the Section Otolaryngology)
Understanding Syncope: Multidisciplinary Approaches to Diagnosis and Management
edited by and Sérgio Laranjo
submission deadline 31 May 2026 | 4 articles | Viewed by 4881 | Submission Open
Keywords: syncope; diagnostic strategies; prognostication; treatment options; quality of life; wearable devices; artificial intelligence; autonomic dysfunction; orthostatic hypotension; POTS (postural orthostatic tachycardia syndrome)
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Updates on Prosthodontics
edited by and Carla Fons-Badal
submission deadline 31 May 2026 | 3 articles | Viewed by 2782 | Submission Open
Keywords: dental prosthesis; dental implants; gingival aesthetics; gingival treatment; dental aesthetics; dental ceramics; BOPT; surgical periodontal treatment
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Advances in Male Infertility: Diagnosis, Management and ART Integration
edited by Despoina Mavrogianni and Sofoklis Stavros
submission deadline 31 May 2026 | Viewed by 1217 | Submission Open
Keywords: male infertility; assisted reproductive technologies (ART); intracytoplasmic sperm injection (ICSI); genetic testing; hormonal profiling; seminal biomarkers; sperm retrieval techniques; sperm selection; stem cell therapy; gene editing; reproductive endo-crinology; early pregnancy; implantation failure; recurrent miscarriage
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Early Prevention and Diagnosis of Atherosclerosis: From Clinical Progression to Patient Management submission deadline 31 May 2026 | 1 articles | Viewed by 372 | Submission Open
Keywords: atherosclerosis; atherothrombotic molecular pathways; cardiovascular risk; monitoring of goals; pharmacological and non-pharmacological prevention; carotid and peripheral interventions
(This special issue belongs to the Section Cardiovascular Medicine)
Personalized Management of Abdominal Surgery and Complications
edited by Ioannis Mantzoros and
submission deadline 31 May 2026 | Viewed by 105 | Submission Open
Keywords: personalized medicine; abdominal surgery; complications; emergency; innovative surgery
(This special issue belongs to the Section General Surgery)
Clinical Advances and Contemporary Applications of Echocardiography
edited by
submission deadline 31 May 2026 | Viewed by 77 | Submission Open
Keywords: echocardiography; speckle-tracking; three-dimensional; Doppler; cardiac; valve; vasculature
(This special issue belongs to the Section Cardiovascular Medicine)
Current Advances and Future Challenges in Heart Transplantation
edited by
submission deadline 31 May 2026 | Viewed by 71 | Submission Open
Keywords: heart transplantation; indication; surgical techniques; preoperative care; immunosuppressive regimens; mechanical circulatory support; donor assessment and management; cardiac donation after circulatory death; ex vivo machine perfusion; normothermic regional perfusion; cardiac xenotransplantation
(This special issue belongs to the Section Cardiology)
Advance in the Management of Cancer Pain
edited by Wojciech Leppert
submission deadline 31 May 2026 | Viewed by 41 | Submission Open
Keywords: analgesia; analgesics; cancer patients; chronic pain; pain in cancer patients; pain assessment; non-opioids; opioid analgesics; adjuvant analgesics; non-pharmacology methods of pain management
(This special issue belongs to the Section Epidemiology & Public Health)
Applications of Artificial Intelligence (AI) in Surgery submission deadline 31 May 2026 | Viewed by 39 | Submission Open
Keywords: artificial intelligence; machine learning; surgical robotics; computer vision; predictive analytics; surgical decision support; perioperative care; surgical outcomes; digital surgery
(This special issue belongs to the Section General Surgery)
Diagnosis and Treatment of Pediatric Endocrine Disorders—Focus on Rare Conditions
edited by Sophia Sakka
submission deadline 1 Jun 2026 | Viewed by 1116 | Submission Open
Keywords: pediatric endocrinology; diabetes mellitus in children; bone metabolism disorders; clinical diagnosis; therapeutic strategies; skeletal dysplasias; rare endocrine conditions; pediatric type 1 diabetes; rickets management; genetic conditions; pediatric hormone therapy; achondroplasia
(This special issue belongs to the Section Endocrinology & Metabolism)
Orthodontics: State of the Art and Prospects
edited by Beatriz Tarazona-Álvarez and
submission deadline 5 Jun 2026 | 1 articles | Viewed by 1654 | Submission Open
Keywords: digital orthodontics; clear aligners; 3D printing; accelerated orthodontics; digital treatment plan; nanotechnology
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Latest Research on Male Infertility submission deadline 5 Jun 2026 | Viewed by 555 | Submission Open
Keywords: testis; sperm; seminal plasma; spermatogenesis; fertilization; omics; proteomics; oxidative stress; sperm DNA fragmentation; varicocele; male infertility; testicular cancer; infertility management; ART
(This special issue belongs to the Section Reproductive Medicine & Andrology)
New Insights on Pharmacologic and Non-Pharmacologic Therapy of Advanced Heart Failure
edited by
submission deadline 5 Jun 2026 | Viewed by 56 | Submission Open
Keywords: advanced heart failure (AHF); mechanical circulatory support systems; heart transplantation (HTx); immunosuppression; cardiac allograft rejections
(This special issue belongs to the Section Cardiology)
Sjogren’s Syndrome: Clinical Advances and Insights
edited by David A. Isenberg
submission deadline 7 Jun 2026 | Viewed by 60 | Submission Open
Keywords: xerostomia; xerophthalmia; non-Hodgkins lymphoma; autoimmune rheumatic diseases; Sjogren’ s syndrome
(This special issue belongs to the Section Immunology & Rheumatology)
Clinical Research and Personalized Medicine in Inflammatory Bowel Disease
edited by and Loris Riccardo Lopetuso
submission deadline 10 Jun 2026 | 4 articles | Viewed by 4803 | Submission Open
Keywords: inflammatory bowel disease (IBD); personalized medicine; precision medicine; Crohn’ s disease; ulcerative colitis; targeted therapy; artificial intelligence
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Cardiovascular Health: Advances in Prevention, Treatment and Innovative Therapies
edited by
submission deadline 10 Jun 2026 | Viewed by 1165 | Submission Open
Keywords: atherosclerosis; dyslipidemia; cardiac risk factors; premature ASCVD; left atrium function; atrial fibrillation; coronary imaging
(This special issue belongs to the Section Cardiovascular Medicine)
Surgical Management of Maxillofacial Fractures and Reconstruction of Facial Deformities
edited by , and Francesco Arcuri
submission deadline 10 Jun 2026 | 2 articles | Viewed by 770 | Submission Open
Keywords: head and neck reconstruction; facial fractures; minimally invasive treatments; facial reconstruction; bioengineering in head and neck disorders; CAD/CAM in maxillo facial trauma and deformities
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Diabetes Mellitus and Emerging Health Challenges: A Multidisciplinary Perspective
edited by Katarzyna A. Majewska and
submission deadline 10 Jun 2026 | 1 articles | Viewed by 344 | Submission Open
Keywords: diabetes mellitus; type 1 diabetes; type 2 diabetes; diabetic complications; prediabetes; diabetes treatment; autoimmune diabetes
(This special issue belongs to the Section Endocrinology & Metabolism)
Clinical Outcomes Improvement and Perioperative Management of Surgical Patients: 3rd Edition submission deadline 10 Jun 2026 | Viewed by 58 | Submission Open
Keywords: clinical outcomes; surgery; quality; quality of life; quality improvement; postoperative; morbidity; postoperative care
(This special issue belongs to the Section General Surgery)
Clinical and Diagnostic Strategies for Glioma Treatment
edited by Aleksandrs Krigers and Egils Valeinis
submission deadline 10 Jun 2026 | Viewed by 56 | Submission Open
Keywords: glioma; glioblastoma; astrocytoma; oligodendroglioma; IDH; neuro-oncology; neurosurgery; radiotherapy; neuropathology; diagnostics; treatment
(This special issue belongs to the Section Clinical Neurology)
Cardiac Arrest and Postcardiac Arrest Care: State of the Art and Future Directions
edited by and Soheil Saadat
submission deadline 10 Jun 2026 | Viewed by 53 | Submission Open
Keywords: out-of-hospital cardiac arrest; cardiopulmonary resuscitation; postcardiac arrest syndrome; postcardiac arrest care; survival; neurologic outcomes
(This special issue belongs to the Section Emergency Medicine)
Cardiomyopathy: Diagnosis and Therapeutic Advances
edited by Ilaria Dentamaro and Annagrazia Cecere
submission deadline 10 Jun 2026 | Viewed by 50 | Submission Open
Keywords: cardiomiopathy; cardiac magnetic resonance (CMR); advanced echocardiography; heart failure; hypertrophic cardiomyopathy
(This special issue belongs to the Section Cardiology)
New Technologies for Personalized Medicine in Head and Neck Surgery submission deadline 10 Jun 2026 | Viewed by 47 | Submission Open
Keywords: personalized medicine; head and neck surgery; 3D printing; surgical navigation; artificial intelligence; computer-assisted surgery; regenerative medicine; precision oncology; craniofacial reconstruction; biomaterials; virtual surgical planning; genomics and proteomics; tissue engineering; functional rehabilitation
(This special issue belongs to the Section Otolaryngology)
Systemic Sclerosis: State of the Art and Future Directions
edited by Antonino Mazzone and
submission deadline 12 Jun 2026 | Viewed by 45 | Submission Open
Keywords: systemic sclerosis; current knowledge; advanced knowledge; vasculopathy; interstitial lung disease; pulmonary arterial hypertension; perspectives; novelties
(This special issue belongs to the Section Dermatology)
Evidence-Based Clinical Management of Orthopaedic Trauma: 25 Years in Retrospect, and a Forecast of 25 Years to Come
edited by Dirk Stengel and
submission deadline 15 Jun 2026 | 5 articles | Viewed by 9403 | Submission Open
Keywords: evidence-based medicine; orthopaedic surgery; clinical trials; systematic reviews; patient outcomes; multiple trauma; artificial intelligence; injuries
(This special issue belongs to the Section Orthopedics)
Advances in the Diagnosis and Treatment of Glaucoma
edited by
submission deadline 15 Jun 2026 | 4 articles | Viewed by 4554 | Submission Open
Keywords: OCT; glaucoma; MIGS; neuroprotection; drug delivery systems; artificial intelligence; pharmacologic agents; per-sonalized medicine
(This special issue belongs to the Section Ophthalmology)
Gender Differences and Diversity in the Treatment of Gastric Cancer and Other Malignancies
edited by Claus Schildberg and Frank Meyer
submission deadline 15 Jun 2026 | 2 articles | Viewed by 1367 | Submission Open
Keywords: gastric cancer; other cancers; other treatment; gender differences; diversity; new challances
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Updates on Valvular Heart Diseases: A New Era in Personalized Treatment
edited by Massimiliano Mariani
submission deadline 15 Jun 2026 | 2 articles | Viewed by 1189 | Submission Open
Keywords: valvular heart disease; structural heart intervention; imaging in valve disease; interventional echocardiography; minimally invasive cardiac surgery; aortic valve intervention; tricuspid valve intervention; valve intervention in GUCH; patient-specific therapy; advanced diagnostic techniques; gutting-edge cardiac imaging; catheter-based interventions; innovative cardiac therapies
(This special issue belongs to the Section Cardiology)
Cardiac Arrest: Strategies, Innovations, and Improvements in Outcomes
edited by
submission deadline 15 Jun 2026 | Viewed by 961 | Submission Open
Keywords: cardiac arrest; cardiopulmonary resuscitation; post-cardiac arrest syndrome; neurological outcomes
(This special issue belongs to the Section Cardiology)
Blood Cancers: Current Status and Future Challenges
edited by and Massimo Breccia
submission deadline 15 Jun 2026 | 1 articles | Viewed by 949 | Submission Open
Keywords: acute myeloid leukemia; hematology; leukemia; venetoclax; blood disorders
(This special issue belongs to the Section Hematology)
Transjugular Intrahepatic Portosystemic Shunt: Challenges and Perspectives—2nd Edition
edited by , Stefania Gioia and
submission deadline 15 Jun 2026 | 1 articles | Viewed by 573 | Submission Open
Keywords: hepatic encephalopathy; spontaneous portal-systemic shunts; transjugular intrahepatic portosystemic shunt; cirrhosis; portal hypertension; sarcopenia; myosteatosis; gastrointestinal bleeding; ascites; non cirrhotic portal hypertension
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Congenital Heart Diseases: Epidemiology, Treatment and Lifelong Support
edited by Sebastian Freilinger, , and Oliver Dewald
submission deadline 15 Jun 2026 | 1 articles | Viewed by 453 | Submission Open
Keywords: congenital heart disease (CHD); adults with CHD; epidemiology; comorbidities; intervention; surgical treatment; psychological aspects; quality of life (QoL); risk factors; rehabilitation; health promotion; prevention; health literacy; physical activity; lifelong support
(This special issue belongs to the Section Cardiology)
Dental Implantology: Clinical Updates and Perspectives—2nd Edition
edited by
submission deadline 15 Jun 2026 | Viewed by 93 | Submission Open
Keywords: dental implantology; reconstructive surgery; biomaterials; tissue engineering; regenerative medicine; digital dentis-try; periimplantitis; peri-implant soft tissues
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
New Advances of Infectious Disease Epidemiology submission deadline 15 Jun 2026 | Viewed by 87 | Submission Open
Keywords: infectious disease epidemiology; genomic sequencing; computational modeling; collaborative surveillance; digital epidemiology; one health; pandemic intelligence; public health data integration; emerging pathogens; epidemiologic insights
(This special issue belongs to the Section Epidemiology & Public Health)
Traumatic Brain Injury: Clinical Diagnosis and Management
edited by Alessio Caccioppola
submission deadline 15 Jun 2026 | Viewed by 80 | Submission Open
Keywords: glasgow coma scale; intracranial pressure monitoring; traumatic brain injury; diffuse axonal injury; post-traumatic epilepsy; decompressive craniectomy; neuromonitoring
(This special issue belongs to the Section Brain Injury)
Current Challenges and Opportunities in Assisted Reproductive Technologies
edited by Andrea Milostić-Srb and
submission deadline 15 Jun 2026 | Viewed by 65 | Submission Open
Keywords: artificial reproductive technologies; ART; mental health effect on ART; IVF; AI in reproductive medicine
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Advancements in Foot and Ankle Surgery: 2nd Edition
edited by
submission deadline 15 Jun 2026 | Viewed by 60 | Submission Open
Keywords: flat foot; hindfoot motion; diabetic foot; hallux valgus; foot infection; foot trauma
(This special issue belongs to the Section Orthopedics)
Clinical Diagnosis and Management of Erectile Dysfunction
edited by Maurizio De Rocco Ponce and
submission deadline 15 Jun 2026 | Viewed by 27 | Submission Open
Keywords: erectile dysfunction; clinical management; cardiovascular disease; penile prosthesis; personalized medicine; hipogonadism
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Aortic Surgery: State of the Art and Future Directions submission deadline 15 Jun 2026 | Viewed by 26 | Submission Open
Keywords: aortic surgery; aortic aneurysm; aortic dissection; aortic arch; biomaterials; endovascular approach; FET; TEVAR
(This special issue belongs to the Section Cardiovascular Medicine)
Novel Diagnostic and Therapeutic Perspectives in Systemic Sclerosis
edited by Mislav Radić
submission deadline 15 Jun 2026 | Viewed by 16 | Submission Open
Keywords: systemic sclerosis; biomarkers; diagnosis; treatment; diagnostic imaging technique; early detection
(This special issue belongs to the Section Immunology & Rheumatology)
Gynecologic Oncology: Current Therapies and New Frontiers
edited by Laura Paleari and Mariangela Rutigliani
submission deadline 19 Jun 2026 | Viewed by 57 | Submission Open
Keywords: ovarian cancers; gynecological cancer; drug delivery; AI; screening; new therapies
(This special issue belongs to the Section Obstetrics & Gynecology)
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