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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Innovation in Endoscopic Sinus and Anterior Skull Base Surgery

edited by

Samiul Muquit

and

Marios Stavrakas

submission deadline 15 May 2026 | 1 articles | Viewed by 347 | Submission Open

Keywords: rhinology; endoscopic anterior skull base surgery; anterior skull base surgery; endoscopic sinus surgery; chronic rhinosinusitis (CRS); otolaryngology

(This special issue belongs to the Section Otolaryngology)

Neuroendocrine Neoplasms: Epidemiology, Clinical Management, and Emerging Therapies

edited by

H. Christian Weber

submission deadline 15 May 2026 | Viewed by 256 | Submission Open

Keywords: neuroendocrine neoplasms (NENs); epidemiology; biomarkers for NENs; targeted therapies for NENs; carcinoid syndrome; precision medicine; gastrointestinal NENs; advanced endoscopic approaches to NEN treatment; imaging modalities for NENs; survival risk factors in NENs

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Mechanisms and Management of Intracerebral Hemorrhage

edited by Emanuela Crobeddu

submission deadline 15 May 2026 | Viewed by 199 | Submission Open

Keywords: intracerebral hemorrhage; arteriovenous malformation (AVM); dural arteriovenous fistula (DAVF); cavernoma; neuroinflammation; blood– brain barrier; hematoma evacuation; neuroprotection; imaging technologies; vascular lesions

(This special issue belongs to the Section Clinical Neurology)

Clinical Updates on Pediatric Surgery

edited by Carlos Theodore Huerta and Eduardo Alfonso Perez

submission deadline 15 May 2026 | Viewed by 193 | Submission Open

Keywords: pediatric surgery; robotic-assisted surgery; artificial intelligence; enhanced recovery after surgery; minimally inva-sive surgery; augmented reality

(This special issue belongs to the Section Clinical Pediatrics)

Pediatric Pulmonology: Current Hurdles and Future Perspectives

edited by Isabel Delgado-Pecellín and Anselmo Andrés-Martín

submission deadline 15 May 2026 | Viewed by 154 | Submission Open

Keywords: interstitial lung diseases; neonatal screening; complex chronic patients; home mechanical ventilation; severe asthma; telemonitoring; lung development; cystic fibrosis; genetics

(This special issue belongs to the Section Clinical Pediatrics)

Clinical Updates on Maternal Fetal Medicine: 2nd Edition

edited by

Roberta Granese

and

Gabriele Tonni

submission deadline 15 May 2026 | Viewed by 140 | Submission Open

Keywords: diabetes in pregnancy; hypertension in pregnancy; cholestasis in pregnancy; endocrine disorder in pregnancy; sepsis in pregnancy

(This special issue belongs to the Section Obstetrics & Gynecology)

Damage Control Surgery: New Insights into Resuscitation, Operative Strategies and Complications

edited by

Bruno de La Villéon

submission deadline 15 May 2026 | Viewed by 137 | Submission Open

Keywords: damage control surgery; damage control resuscitation; polytrauma management; massive transfusion protocol; hemorrhagic shock; trauma laparotomy; staged laparotomy; temporary abdominal closure; multidisciplinary trauma care

(This special issue belongs to the Section General Surgery)

Root Canal Treatment and Healing Outcomes: Clinical Application of Endodontic Biomaterials and Postoperative Management

edited by

Fausto Zamparini

Carlo Prati

and

Andrea Spinelli

submission deadline 15 May 2026 | Viewed by 106 | Submission Open

Keywords: root canal treatment; healing outcomes; endodontic biomaterials; bioceramic sealers; postoperative management; clinical evidence; periapical healing; post operative pain; dentistry

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Heart Failure: Challenges and Future Options

edited by Pedro Caravaca-Pérez and Marta Farrero-Torres

submission deadline 15 May 2026 | Viewed by 74 | Submission Open

Keywords: heart failure; cardiorenal syndrome; heart transplantation; ventricular assist devices; biomarkers; precision medicine; advanced therapies; diuretic resistance; risk stratification; multidisciplinary care

(This special issue belongs to the Section Cardiovascular Medicine)

Comprehensive Hernia Surgery: From Clinical Diagnosis to Postoperative Care

edited by Luca Regusci

submission deadline 15 May 2026 | Viewed by 52 | Submission Open

Keywords: ventral hernia; complexe hernias; botox treatment; laparoscopic surgery; robotic surgery

(This special issue belongs to the Section General Surgery)

Head and Neck Cancer: Clinical Diagnosis and Treatment

edited by Enrique Sanz-Garcia, Nicole Chau and Neus Baste

submission deadline 15 May 2026 | Viewed by 50 | Submission Open

Keywords: head and neck; multidisciplinary approaches; biomarkers; early detection; therapies

(This special issue belongs to the Section Otolaryngology)

Hypertrophic Cardiomyopathy: Lights and Shadows of Structural Pharmacological Treatment

edited by Daniel Dalos

submission deadline 15 May 2026 | Viewed by 46 | Submission Open

Keywords: hypertrophic cardiomyopathy; treatment; myosin inhibition; ventricular arrhythmia; atrial fibrillation

(This special issue belongs to the Section Cardiology)

Spinal Disorders: Current Treatment and Future Opportunities: Third Edition

edited by

Alan H Daniels

submission deadline 15 May 2026 | Viewed by 34 | Submission Open

Keywords: spine; spine surgery; spondylolisthesis; scoliosis; cervical myelopathy; spine surgery training; disc replacement; spine trauma; spine infection; spine fracture; spinal epidural abscess

(This special issue belongs to the Section Orthopedics)

PET Imaging in Bone and Non-Bone Diseases

edited by

Tanuj Puri

and

Glen Blake

submission deadline 19 May 2026 | 2 articles | Viewed by 4386 | Submission Open

Keywords: PET; bone metabolism; bone diseases; metabolic bone diseases; image analysis; radiomics; artificial intelligence

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Bruxism and Temporomandibular Disorders: Current Advances and Future Challenges

edited by

Grzegorz Zieliński

and

Eiji Tanaka

submission deadline 20 May 2026 | 25 articles | Viewed by 51229 | Submission Open

Keywords: TMDs; TMJ; rehabilitation; physiotherapy; craniofacial disorder; oral health; biomechanics; masticatory muscles; electromyography; parafunction; nocturnal bruxism; tooth contact habit

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Cardiovascular Disease in the Elderly: Prevention and Diagnosis

edited by Ioana Dana Alexa, Gabriel Ioan Prada and

Ciprian Rezus

submission deadline 20 May 2026 | 7 articles | Viewed by 21216 | Submission Open

Keywords: cardiovascular risk factors; elderly patients; frailty; sarcopenia; heart rate variability; insulin resistance; physical resilience; intrinsic capacity; diastolic dysfunction

(This special issue belongs to the Section Cardiovascular Medicine)

New Advances in Wound Healing and Skin Wound Treatment

edited by Hajime Matsumura

submission deadline 20 May 2026 | 8 articles | Viewed by 15239 | Submission Open

Keywords: trauma wound; burns; chronic wound; DFU; VLU; ischemic wound; regenerative medicine in wound care; debridement; biofilm; wound dressing; antimicrobial treatment

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Pediatric Dentistry: Recent Advances, Current Issues and Future Challenges

edited by

Liliana Szyszka-Sommerfeld

and

Krzysztof Woźniak

submission deadline 20 May 2026 | 6 articles | Viewed by 13278 | Submission Open

Keywords: pediatric dentistry; recent advances; current issues; future challenges; orthodontic issues; preventive strategies; access to care disparities; behavioral management; multidisciplinary collaboration; oral health

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Endometriosis: Clinical Challenges and Prognosis

edited by

Francisco Artacho-Cordon

submission deadline 20 May 2026 | 5 articles | Viewed by 9411 | Submission Open

Keywords: endometriosis; therapy; rehabilitation; psychology; diagnostics; ultrasound imaging; metabolomics; prognosis

(This special issue belongs to the Section Obstetrics & Gynecology)

Cardiac Imaging in the Diagnosis and Management of Heart Failure

edited by Mahi Lakshmi Ashwath and Allen S. Anderson

submission deadline 20 May 2026 | 2 articles | Viewed by 8822 | Submission Open

Keywords: echocardiography; cardiac MRI; myocardial viability; tissue characterization; ischemic and non-ischemic cardiomyopathy; HFpEF; myocardial strain

(This special issue belongs to the Section Cardiology)

Chronic Lung Conditions: Integrative Approaches to Long-Term Care

edited by

Antigona Carmen Trofor

submission deadline 20 May 2026 | 4 articles | Viewed by 8758 | Submission Open

Keywords: chronic lung conditions: chronic non-infectious lung disease and post-respiratory infectious syndromes; including TB sequelae; TB MDR; post-COVID-19; and bronchiectasis; long-term care; integrative approach; multidisciplinary; multimorbidity; outcomes

(This special issue belongs to the Section Respiratory Medicine)

Novel Insights into the Prevention and Treatment of Contact Dermatitis

edited by

Cara Bieck

, Christoph Skudlik, Swen Malte John and

Albert Nienhaus

submission deadline 20 May 2026 | 4 articles | Viewed by 8593 | Submission Open

Keywords: allergic; allergy; contact dermatitis; irritant; occupation; prevention; sensitization; skin; therapy; treatment

(This special issue belongs to the Section Dermatology)

Effect of Long-Term Insomnia on Mental Health—2nd Edition

edited by

Aleksandra Rogowska

submission deadline 20 May 2026 | 1 articles | Viewed by 8002 | Submission Open

Keywords: anxiety; alcohol and substance use disorders; behavioral addiction; burnout; cognitive dysfunction; depression; eating disorders; gaming addiction; problematic internet/social media use; insomnia; long-term insomnia; mood disorders; post-traumatic stress disorder; stress

(This special issue belongs to the Section Mental Health)

State of the Art in Neuromodulation or Spinal Cord Stimulation Therapy

edited by Marco Mercieri

submission deadline 20 May 2026 | 3 articles | Viewed by 7945 | Submission Open

Keywords: neuromodulation; spinal cord stimulation; chronic pain management; stimulation waveforms; long-term efficacy; loss of efficacy; outcome prediction; opioid-sparing techniques; neurostimulation mechanisms; psychological predictors; therapeutic targets

(This special issue belongs to the Section Clinical Neurology)

Advances in Spine Surgery: Best Practices and Future Directions

edited by Martin N. Stienen and

Stefan Motov

submission deadline 20 May 2026 | 7 articles | Viewed by 7380 | Submission Open

Keywords: minimally invasive spine surgery; spinal endoscopy; spinal robotics; spinal navigation; ERAS; machine learning; artificial intelligence; complication management; revision surgery; spinal deformity; innovation; future direction

(This special issue belongs to the Section Clinical Neurology)

Transcatheter Aortic Valve Implantation: Recent Advances and Future Directions

edited by

Alon Shechter

and Pablo Codner

submission deadline 20 May 2026 | 6 articles | Viewed by 6934 | Submission Open

Keywords: transcatheter aortic valve implantation; transcatheter aortic valve replacement; aortic valve stenosis; aortic valve regurgitation; aoric valve disease; cardiac imaging; artifical intelligence; machine learning

(This special issue belongs to the Section Cardiovascular Medicine)

New Advances in Myasthenia Gravis

edited by Shingo Konno

submission deadline 20 May 2026 | 3 articles | Viewed by 5364 | Submission Open

Keywords: myasthenia gravis; clinical trials; translational research; drug repurposing; biological markers; experimental autoimmune myasthenia gravis

(This special issue belongs to the Section Clinical Neurology)

Neural Application of Artificial Intelligence in Clinical Neuroscience

edited by Saurabh J. Singhal

submission deadline 20 May 2026 | 3 articles | Viewed by 5041 | Submission Open

Keywords: artificial intelligence (AI); clinical neuroscience; neuroimaging; brain– computer interfaces (BCIs); neuroprosthetics; EEG/EMG analysis; robotic surgery; deep brain stimulation (DBS); drug discovery; telemedicine; neurorehabilitation; stroke detection; Alzheimer’ s disease; brain tumors; seizure prediction

(This special issue belongs to the Section Clinical Neurology)

Advances in Retinal Diseases—Mechanisms, Diagnostics, and Emerging Therapies

edited by

Minzhong Yu

submission deadline 20 May 2026 | 2 articles | Viewed by 3936 | Submission Open

Keywords: inherited retinal diseases; age-related macular degeneration; diabetic retinopathy; multimodal retinal imaging; treatment

(This special issue belongs to the Section Ophthalmology)

Updates on Cardiac Pacing and Electrophysiology

edited by

Axel Brandes

submission deadline 20 May 2026 | 4 articles | Viewed by 3870 | Submission Open

Keywords: pacemaker; conduction system pacing; leadless pacemaker; implantable cardioverter– defibrillator; ICD; extravascular ICD; S-ICD; lead extraction; supraventricular tachycardia; ventricular tachycardia; cardio-neuro ablation

(This special issue belongs to the Section Cardiology)

New Advances in Uterus and Ovarian Transplantation: 2nd Edition

edited by

Elliott G. Richards

submission deadline 20 May 2026 | 2 articles | Viewed by 3769 | Submission Open

Keywords: uterus transplantation; gynaecological surgery; endometriosis; IVF; fibroids; reproductive medicine; laparoscopic surgery; assisted reproductive technology; reproductive endocrinology

(This special issue belongs to the Section Obstetrics & Gynecology)

Challenges in Reproductive Health

edited by

Loris Marin

and Guido Ambrosini

submission deadline 20 May 2026 | 2 articles | Viewed by 3649 | Submission Open

Keywords: fertility preservation; oocytes cryopreservation; embryo cryopreservation; ovarian tissue transplantation; gonadotoxic therapy

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Prostate Cancer: Diagnosis, Clinical Management and Prognosis

edited by Giovanni Muto

submission deadline 20 May 2026 | 3 articles | Viewed by 3528 | Submission Open

Keywords: prostate cancer; diagnosis; clinical management; prognosis; treatments

(This special issue belongs to the Section Nephrology & Urology)

Clinical Update in Pulmonary Rehabilitation

edited by Akira Tamaki

submission deadline 20 May 2026 | 3 articles | Viewed by 3209 | Submission Open

Keywords: pulmonary rehabilitation; chronic obstructive pulmonary disease; interstitial lung disease; sarcopenia; respiratory sarcopenia; respiratory muscle training; nutritional intervention

(This special issue belongs to the Section Respiratory Medicine)

Clinical Application of Knee Arthroscopy

edited by

Francesco Bosco

and Alessandro Carrozzo

submission deadline 20 May 2026 | 3 articles | Viewed by 2381 | Submission Open

Keywords: knee surgery; arthroscopy; orthopedics; sport medicine; clinical outcomes; ligament reconstruction; meniscal repair; cartilage; postoperative rehabilitation; knee joint; tissue repair; joint preservation

(This special issue belongs to the Section Orthopedics)

Cirrhosis and Its Complications: Prognosis and Clinical Management

edited by

Ana-Maria Singeap

submission deadline 20 May 2026 | 2 articles | Viewed by 2284 | Submission Open

Keywords: cirrhosis; complications; spontaneous bacterial peritonitis; portal hypertension; ascites; hepatorenal syndrome; hepatic encephalopathy; liver transplantation; acute-on-chronic liver failure; hepatocellular carcinoma; quality of life; prognosis; clinical management

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Targeted Diagnosis and Treatment of Shoulder and Elbow Disease: 2nd Edition

edited by

Teresa Paolucci

and

Massimiliano Mangone

submission deadline 20 May 2026 | 2 articles | Viewed by 2220 | Submission Open

Keywords: anterolateral deltoid split; joint pain; axillary nerve injury; rotator cuff injuries; shoulder arthroplasty; shoulder impingement syndrome; proximal humeral fracture; rehabilitation; exercise; physiotherapy; rehabilitative relapses

(This special issue belongs to the Section Orthopedics)

Research Progress in Pediatric Endocrinology

edited by

Federico Baronio

submission deadline 20 May 2026 | 2 articles | Viewed by 1800 | Submission Open

Keywords: pediatric endocrinology; rare endocrine disorders; precision medicine; congenital adrenal hyperplasia (CAH); short stature genetics; severe childhood obesity; glp-1 receptor agonists; endocrine disruptors; artificial intelligence (AI) in endocrinology; newborn screening

(This special issue belongs to the Section Clinical Pediatrics)

Acute Ischemic Stroke: Current Status and Future Challenges—2nd Edition

edited by

Lucio D'Anna

submission deadline 20 May 2026 | 2 articles | Viewed by 1225 | Submission Open

Keywords: acute ischemic stroke; atrial fibrillation; endovascular thrombectomy; intravenous thrombolysis; direct oral anticoagulants

(This special issue belongs to the Section Clinical Neurology)

Advances in Fertility Preservation

edited by Dunja Maria Baston-Büst

submission deadline 20 May 2026 | 1 articles | Viewed by 1113 | Submission Open

Keywords: fertility preservation; gonadotoxic treatment; chemotherapy; transgender; cryopreservation; ejaculate; testicular tissue; mature oocytes; immature oocytes; ovarian tissue; ovarian cortex

(This special issue belongs to the Section Obstetrics & Gynecology)

Current Advances and Future Perspectives in Interventional Cardiology

edited by

Jacob Zeitani

submission deadline 20 May 2026 | 1 articles | Viewed by 1080 | Submission Open

Keywords: trans-catheter valve repair and replacement; advanced coronary intervention; AI in decision making for trans-catheter aortic root and arch replacement; LAA occlusion; anti-arrhythmic therapy; right side of the heart

(This special issue belongs to the Section Cardiology)

Diagnosis and Treatment of Ocular Surface Diseases

edited by

Stuti Misra

and

Sònia Travé-Huarte

submission deadline 20 May 2026 | 1 articles | Viewed by 1057 | Submission Open

Keywords: dry eye disease; ocular surface; anterior segment imaging; biomarkers; artificial intelligence; diagnostic tools; novel therapeutic agents; anterior eye care

(This special issue belongs to the Section Ophthalmology)

Recent Advances in Adverse Pregnancy and Neonatal Outcomes

edited by

Sae-kyung Choi

submission deadline 20 May 2026 | 1 articles | Viewed by 1028 | Submission Open

Keywords: maternal and fetal; adverse pregnancy; neonatal outcomes; newborns; cesarean section

(This special issue belongs to the Section Obstetrics & Gynecology)

Challenges and Opportunities in Application of Laparoscopic, Robotic and Other Technological Advances in Gastrointestinal Surgery

edited by

Gianluca Cassese

and Fabrizio Panaro

submission deadline 20 May 2026 | 1 articles | Viewed by 1026 | Submission Open

Keywords: robotic surgery; laparoscopic surgery; artificial intelligence; technological advances

(This special issue belongs to the Section General Surgery)

Clinical Management and Long-Term Prognosis in Intensive Care

edited by

Wioletta Mędrzycka-Dąbrowska

and

Sandra Lange

submission deadline 20 May 2026 | 2 articles | Viewed by 981 | Submission Open

Keywords: intensive care; post-intensive care syndrome; patient safety; improved survival; mental health; mechanical ventilation

(This special issue belongs to the Section Intensive Care)

Advances in Minimally Invasive Otolaryngology: Precision Techniques and Functional Outcomes

edited by Giovanni Colombo and

Matteo Di Bari

submission deadline 20 May 2026 | 2 articles | Viewed by 937 | Submission Open

Keywords: advances in otolaryngology; endoscopic surgery; head and neck surgery; functional outcomes; quality of life

(This special issue belongs to the Section Otolaryngology)

New Updates in Pediatric Gastroenterology

edited by

Laura Trandafir

, Alina Stanescu-Popp and Oana Belei

submission deadline 20 May 2026 | Viewed by 933 | Submission Open

Keywords: pediatric gastroenterology and hepatology; inflammatory bowel disease; celiac disease; gastrointestinal diseases; esophageal diseases; endoscopy; gut microbiome; inflammatory bowel disease; functional GI disorders; nutritional management; precision medicine; gut– brain axis; transitional care

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Percutaneous Coronary Intervention: Latest Advances and Future Prospects

edited by

Alessandro Mandurino-Mirizzi

submission deadline 20 May 2026 | 1 articles | Viewed by 707 | Submission Open

Keywords: percutaneous coronary intervention; coronary artery disease; intravascular imaging; intracoronary physiology; high-risk percutaneous coronary intervention; calcified coronary stenosis; chronic total occlusion; bifurcation disease

(This special issue belongs to the Section Cardiology)

Advances in Clinical Rheumatology—2nd Edition

edited by

Jacopo Ciaffi

submission deadline 20 May 2026 | 1 articles | Viewed by 660 | Submission Open

Keywords: rheumatoid arthritis; spondylarthritis; interventional; osteoporosis; complex regional pain syndrome

(This special issue belongs to the Section Immunology & Rheumatology)

Physiotherapy in Clinical Practice: From Assessment to Rehabilitation

edited by

Inés Llamas Ramos

and