Nano-Biomaterials for Biomedicine and Tissue Regeneration
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 28
Special Issue Editors
Interests: tissue engineering strategies for muscle, gut, cartilage, bone and nerve regeneration; biomimetic scaffolds based on synthetic, biologic or composite materials; tissue decellularization and characterization of acellular ECMs; characterization of scaffold ultrastructure and biomechanics, functionalization strategies and biocompatibility/biodegradation studies; cell–biomaterial interactions and preclinical validation in disease models; isolation and characterization of primary and stem cell cultures for applications in cell-based regenerative therapies
Special Issues, Collections and Topics in MDPI journals
Interests: tissue engineering applied to orthopaedics and peripheral nerve regeneration; synthetic and natural biomimetic scaffolds; composite scaffolds; decellularization and extracellular matrix characterization; functionalization strategies; scaffolds ultrastructure and mechanical properties; isolation and characterization of primary cells and stem-cells; evaluation of cell-biomaterial interactions; pre-clinical studies on animal models of disease managed by tissue engineering and regenerative medicine strategies
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The integration of nanotechnology with biomedical sciences has enabled the rational design of biomaterials with nanoscale precision, offering unprecedented control over physicochemical properties and biofunctionality. Nano-biomaterials—including nanoparticles, nanofibers, nanotubes, and self-assembling nanostructures—exhibit high surface area-to-volume ratios, tunable surface chemistry, and the ability to modulate biological responses at cellular and subcellular levels.
This special issue focuses on recent advances in the fabrication, functionalization, and biomedical application of nano-biomaterials for tissue regeneration and therapeutic delivery. Topics include nanostructured scaffolds for guided tissue engineering, stimuli-responsive drug delivery platforms, bioinstructive surfaces for cell modulation, and nanostructured platforms for diagnostic and therapeutic integration. Particular attention is given to material-biology interactions, immune modulation, and the role of nanoscale architecture in directing cellular behavior, angiogenesis, and extracellular matrix remodeling.
Translational challenges—including biocompatibility, in vivo stability, controlled biodegradability, and regulatory considerations for clinical applications—are critically addressed.
By consolidating contributions from materials science, regenerative medicine, nanomedicine, and bioengineering, this issue aims to advance nano-biomaterials as key enablers of next-generation regenerative and precision therapies.
Dr. Silvia Barbon
Dr. Elena Stocco
Guest Editors
Manuscript Submission Information
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Keywords
- nanostructured biomaterials
- cell-scaffold interactions
- drug delivery systems
- tissue engineering
- regenerative medicine
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