New Advances in Infectious and Immunoinflammatory Mechanisms of Alzheimer's Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 166
Special Issue Editor
Interests: microglia; brain inflammation; cathepsins; Alzheimer's disease; porphyromonas gingivalis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Alzheimer’s disease is one of the most common neurodegenerative disorders, and elucidating its pathogenic mechanisms as well as establishing effective therapeutic strategies remain major challenges. To date, the “amyloid cascade hypothesis” has been widely accepted, and various therapeutic strategies targeting the production, aggregation, and deposition of amyloid β have been developed. However, it remains difficult to conclude that these approaches have led to the establishment of disease-modifying therapies capable of sufficiently halting disease progression. In recent years, antibody-based therapies that promote the clearance of amyloid β have been introduced into clinical practice and have shown some efficacy in slowing disease progression in early-stage patients. Nevertheless, their therapeutic effects appear to depend on the stage of disease progression. Given these limitations, there is an increasing need to reconsider the current framework of Alzheimer’s disease pathogenesis and therapeutic strategies. One emerging perspective is the “infectious hypothesis,” which has recently re-emerged as a compelling and actively debated framework, emphasizing the roles of immune responses and neuroinflammation in disease onset and progression.
In this Special Issue, we aim to provide a platform for critical discussion and interdisciplinary perspectives on the infectious hypothesis of Alzheimer’s disease, including studies on microbial involvement, host–pathogen interactions, innate immunity, and neuroinflammation. We hope that this collection will contribute to a deeper understanding of disease mechanisms and foster the development of innovative therapeutic strategies.
Prof. Dr. Hiroshi Nakanishi
Guest Editor
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Keywords
- Alzheimer's Disease
- amyloid
- neuroinflammation
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