Research on Immune Mechanisms in Kidney Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 January 2026 | Viewed by 51
Special Issue Editor
Special Issue Information
Dear Colleagues,
Immune activation is a key driver of both acute kidney injury (AKI) and chronic kidney disease (CKD), promoting fibroinflammation and organ dysfunction. This response is triggered by the extracellular and intracellular sensing of injury-related cues, including damage-associated molecular patterns (DAMPs), hypoxia, temperature changes, and mechanical stress. Toll-like receptors (TLRs) detect extracellular or endosomal DAMPs, while cytosolic pathways such as cGAS–STING, AIM2, and RIG-I–MAVS respond to self-nucleic acids and other intracellular signals. These sensors converge on inflammatory, fibrotic, and metabolic pathways, driving immune cell recruitment and epithelial injury.
For this Special Issue, we welcome original research and reviews that explore recent advances in the following areas:
- The molecular mechanisms behind AKI and CKD;
- DNA/RNA sensing in renal disease;
- Metabolic stress sensors (e.g., HIF-1α);
- Mechanosensors, thermosensors, and gustatory receptors in kidney injury;
- Bacterial metabolite sensing (e.g., GPCRs) and the kidney–gut axis.
We look forward to receiving your contributions.
Prof. Dr. Niels Olsen Saraiva Câmara
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- kidney disease
- molecular sensors
- kidney metabolism
- immunity
- AKI to CKD transition
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
