Inflammatory Bowel Disease and Cardiometabolic Comorbidities: Molecular Mechanisms and Therapeutic Perspectives
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 1
Special Issue Editors
Interests: cardiovascular disease; heart failure; cardiometabolic medicine, obesity
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cardio–kidney–metabolic (CKM) syndrome has been proposed to address the interconnection between cardiovascular disease, chronic kidney disease and metabolic co-morbidities, including type 2 diabetes, obesity and dyslipidemia, since all the above mentioned medical conditions share common pathogenetic mechanisms. Growing evidence suggests a significant relationship between certain components of CKM syndrome and inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis. Chronic systemic inflammation, a hallmark of IBD, contributes to endothelial dysfunction; additionally, it is also associated with macrovascular dysfunction, resulting in enhanced cardiovascular risk. In addition, alterations in gut microbiota and immune dysregulation may promote metabolic abnormalities and renal impairment. Understanding this bidirectional relationship is crucial for early risk assessment, appropriate diagnostic approach selection and multidisciplinary, multilevel therapeutic management.
Thereofore, we are pleased to invite you to submit your own research to our Special Issue entitled “Inflammatory Bowel Disease and Cardiometabolic Comorbidities: Molecular Mechanisms and Therapeutic Perspectives” in the International Journal of Molecular Sciences, which will address this close interconnection between CKM syndrome and IBD. Our Special Issue will encompass both basic and clinical research articles on this specific, bidirectional association, and review articles (both narrative and systematic) are also welcome.
We look forward to receiving your contributions.
Dr. Dimitrios Patoulias
Dr. Christos Mademlis
Guest Editors
Manuscript Submission Information
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Keywords
- cardiovascular–kidney–metabolic syndrome
- diabetes
- obesity
- cardiovascular disease
- inflammatory bowel disease
- Crohn’s disease
- ulcerative colitis
- inflammation
- endothelial dysfunction
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