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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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A Window to the Brain: From Retinal Cellular and Soluble Biomarkers Towards Neurodegeneration submission deadline 31 Mar 2026 | Viewed by 110 | Submission Open
Keywords: retinal signaling; oxidative stress; retinal neurodegeneration; biomarkers; therapeutic targets
(This special issue belongs to the Section Molecular Neurobiology)
Oxidative Stress and Mitochondrial Dysfunction in Human Diseases
edited by Patrice X. Petit
submission deadline 31 Mar 2026 | Viewed by 110 | Submission Open
Keywords: aging; DAMPs; inflammation; Fenton reaction; ferroptosis; hydroperoxide; mitochondria; mitophagy; NIX; NLRP3; oxidized mtDNA; RIRR; superoxide anions; stem cells
(This special issue belongs to the Section Molecular Biology)
Research on Stem Cells in Neurological Disorders: Disease Modeling and Therapy
edited by
submission deadline 31 Mar 2026 | Viewed by 108 | Submission Open
Keywords: disease modeling; molecular regulation; therapeutic intervention; neurological disorders
(This special issue belongs to the Section Molecular Neurobiology)
Latest Research on Mesenchymal Stem Cells (2nd Edition)
edited by Marcel Costuleanu
submission deadline 31 Mar 2026 | Viewed by 108 | Submission Open
Keywords: mesenchymal stem cell; MSC; niche; tissue homeostasis; exosomes; microvesicles; cancer; mitochondrial exchange; MSC secretome
(This special issue belongs to the Section Molecular Biology)
Bioactive Compounds Targeting Metabolic Disorders: Molecular Mechanisms and Translational Applications
edited by
submission deadline 31 Mar 2026 | Viewed by 108 | Submission Open
Keywords: bioactive compounds; obesity; type 2 diabetes; insulin resistance; adipose tissue; gut microbiota; inflammation; oxidative stress; nutraceuticals; molecular nutrition
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Polymer Biocomposites: Synthesis, Applications and End-Life submission deadline 31 Mar 2026 | Viewed by 108 | Submission Open
Keywords: polymer biocomposites; biodegradable polymers; molecular design and synthesis; functional modifications; biodegradation
(This special issue belongs to the Section Materials Science)
Regulation by Non-Coding RNAs: 2nd Edition
edited by
submission deadline 31 Mar 2026 | Viewed by 107 | Submission Open
Keywords: lncRNAs; circRNAs; miRNAs
(This special issue belongs to the Section Molecular Biology)
Immunotherapies of Solid Tumors
edited by
submission deadline 31 Mar 2026 | Viewed by 107 | Submission Open
Keywords: immune; solid tumors; anti-tumor; molecular pathways; immunotherapy; tumor microenvironment; checkpoint; CAR T cell; adoptive cell
(This special issue belongs to the Section Molecular Immunology)
Cellular Plasticity in Cancer: Mechanisms, Measurement and Therapeutic Opportunities
edited by Costa Frangou
submission deadline 31 Mar 2026 | Viewed by 106 | Submission Open
Keywords: cellular plasticity; cancer progression; EMT/MET; lineage infidelity; therapy-induced reprogramming; stem-like states; single-cell analysis; spatial transcriptomics; lineage tracing; computational modeling; biomarkers; therapeutic re-sistance; metastasis; solid tumors
(This special issue belongs to the Section Molecular Oncology)
Nanocomplexes and Drug Delivery Systems for Cancer Therapy
edited by
submission deadline 31 Mar 2026 | Viewed by 106 | Submission Open
Keywords: nanocomplexes; drug delivery systems; cancer therapy; nanocarriers; stimuli-responsive systems; theranostics; biomolecules delivery; tumor microenvironment; personalized medicine; multidrug resistance
(This special issue belongs to the Section Molecular Nanoscience)
Recent Genetic Insights into Neurodevelopmental Disorders
edited by Maria Cristina Aspromonte and Emanuela Dazzo
submission deadline 31 Mar 2026 | Viewed by 104 | Submission Open
Keywords: neurodevelopmental disorders; autism spectrum disorder; intellectual disability; attention deficit hyperactivity disorder; epilepsy; motor disorders; chromosomal rearrangements; genetic variant; integrative omics approaches
(This special issue belongs to the Section Molecular Neurobiology)
Apoptosis in Health and Disease: Recent Advances and Future Directions
edited by Shabnam Malik
submission deadline 31 Mar 2026 | Viewed by 101 | Submission Open
Keywords: apoptosis; programmed cell death; health and disease; cellular homeostasis; cancer; neurodegenerative disorders
(This special issue belongs to the Section Molecular Biology)
Genome-Wide Association Studies of Complex Diseases and Related Endophenotypes and Biomarkers
edited by M. Ilyas Kamboh
submission deadline 31 Mar 2026 | Viewed by 101 | Submission Open
Keywords: genome-wide association studies; complex diseases; endophenotypes; biomarkers; rare variants; copy number variants; diverse populations
(This special issue belongs to the Section Molecular Genetics and Genomics)
Ameliorating Effect of Natural Bioactive Compounds on Metabolic Diseases and Their Underlying Molecular Mechanisms
edited by Baojun Xu
submission deadline 31 Mar 2026 | Viewed by 101 | Submission Open
Keywords: metabolic diseases; natural bioactive compounds; molecular mechanism; phytochemicals; curing targets; signaling pathway
(This special issue belongs to the Section Bioactives and Nutraceuticals)
AI-Driven and Physics-Based Modeling in Molecular Engineering Systems
edited by
submission deadline 31 Mar 2026 | Viewed by 100 | Submission Open
Keywords: molecular engineering systems; AI model; physics
(This special issue belongs to the Section Molecular Informatics)
Advances in the Reprogramming of Mitochondrial Signalling and Metabolism in Cancers submission deadline 31 Mar 2026 | Viewed by 99 | Submission Open
Keywords: mitochondrial dynamic; mitochondrial biogenesis; mitochondrial transfer; mitochondrial targeting; mitophagy; oxidative metabolism; mtDNA; ROS; oncometabolism
(This special issue belongs to the Section Molecular Oncology)
Bioactive Compounds: Innovative Technologies for Extraction, Synthesis, and Functional Evaluation submission deadline 31 Mar 2026 | Viewed by 99 | Submission Open
Keywords: bioactive compounds; extraction; synthesis; functional evaluation; molecular aspects; mechanism of action
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Applications of Bioinformatics in Human Disease
edited by Maria Rosaria De Filippo
submission deadline 31 Mar 2026 | Viewed by 98 | Submission Open
Keywords: bioinformatics; omics data; machine learning; biomarker prediction
(This special issue belongs to the Section Molecular Informatics)
Molecular Mechanisms of Nephrotoxicity: From Environmental Toxins to Therapeutic Agents
edited by
submission deadline 31 Mar 2026 | Viewed by 98 | Submission Open
Keywords: pesticides; emerging pollutants; environmental toxicants; therapeutic strategies; nephrology; toxicology; public health
(This special issue belongs to the Section Molecular Toxicology)
Molecular Mechanisms of Mineral Nutrition and Tolerance to Salt and Drought in Plants submission deadline 31 Mar 2026 | Viewed by 97 | Submission Open
Keywords: ionic stress; water stress; salinity; mineral nutrition; uptake and transport; signalling and metabolism; plant-microbe interactions; tolerance mechanisms; plant physiology; climate change
(This special issue belongs to the Section Molecular Plant Sciences)
Solid Tumours in Focus: Tissue Biomarkers and Spatial Technologies in Cancer Pathology
edited by Kathryn Pennel
submission deadline 31 Mar 2026 | Viewed by 96 | Submission Open
Keywords: biomarkers; cancer pathology; spatial biology; molecular mechanisms; tumour microenvironment; cell signalling and communication
(This special issue belongs to the Section Molecular Oncology)
Natural Compounds in Cancer Drugs Treatment and Prevention
edited by
submission deadline 31 Mar 2026 | Viewed by 96 | Submission Open
Keywords: natural compounds; cancer prevention; cancer treatment; drug resistance; secondary metabolites; anticancer agents; molecular mechanisms; clinical trials; drug delivery
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Exploring the Dynamic Interaction Between Large-Pore Channels: Latest Insights
edited by and Viviana Berthoud
submission deadline 31 Mar 2026 | Viewed by 95 | Submission Open
Keywords: connexin hemichannels; pannexin hemichannels; TRP channels; P2X receptors; CAHLM channels
(This special issue belongs to the Section Biochemistry)
Molecular Insights into Cardiomyopathy
edited by
submission deadline 31 Mar 2026 | Viewed by 95 | Submission Open
Keywords: cardiomyopathy; inflammation; molecular mechanisms; targeted therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cutting-Edge Carbon-Based Nanomaterials for Biomedical and Environmental Innovations
edited by Roberto Romeo
submission deadline 31 Mar 2026 | Viewed by 95 | Submission Open
Keywords: carbon-based nanomaterials; carbon dots; biochar; graphene derivatives; biomedical applications; environmental monitoring; sustainable nanotechnology; smart sensors
(This special issue belongs to the Section Molecular Nanoscience)
Natural Product-Based Therapeutics: Molecular Mechanisms and Cellular Modulation
edited by Mario Garcia-Dominguez
submission deadline 31 Mar 2026 | Viewed by 95 | Submission Open
Keywords: natural products; molecular mechanisms; cellular modulation; molecular targets
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Neuroblastoma: Advances in Molecular Pathogenesis and Therapy
edited by Paola Fadda and
submission deadline 31 Mar 2026 | Viewed by 93 | Submission Open
Keywords: neuroblastoma; molecular pathogenesis; MYCN; ALK; epigenetics; non-coding RNAs; tumor microenvironment; immunotherapy; targeted therapy; precision medicine
(This special issue belongs to the Section Molecular Oncology)
Updates on Human Embryonic Stem Cells
edited by
submission deadline 31 Mar 2026 | Viewed by 93 | Submission Open
Keywords: human embryonic stem cells; pluripotent stem cells; differentiation; pluripotency; cell-based therapy; embryo; disease modeling
(This special issue belongs to the Section Molecular Biology)
Application of Pulsed Electric Fields in Cancer Therapy
edited by Siqi Guo
submission deadline 31 Mar 2026 | Viewed by 90 | Submission Open
Keywords: pulsed electric fields; cancer therapy; ablation; minimally invasive; tumor microenvironment; combination therapy
(This special issue belongs to the Section Molecular Oncology)
Emerging Horizons of Innovations, Mechanisms, and Translational Prospects of Chitosan-Based Drug Delivery Therapeutic Interventions
edited by
submission deadline 31 Mar 2026 | Viewed by 88 | Submission Open
Keywords: chemical modification and functionalization; nanostructured and hybrid systems; gene; peptide; and vaccine delivery; mucosal and transdermal applications; biological interactions and mechanistic insights
(This special issue belongs to the Section Molecular Pharmacology)
Advances in Reprogramming of Mitochondrial Signalling and Metabolism in Cancers
edited by
submission deadline 31 Mar 2026 | Viewed by 87 | Submission Open
Keywords: mitochondria; metabolic reprogramming; cancer metabolism; redox signaling
(This special issue belongs to the Section Molecular Oncology)
Neurological and Neurodevelopmental Disorders: Models, Drugs and Technologies
edited by Su-Yun Lyu
submission deadline 31 Mar 2026 | Viewed by 86 | Submission Open
Keywords: neurodevelopmental disorders; disease modeling; molecular mechanisms; neurological; precision medicine; individualized therapeutic strategies
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Antimicrobial Resistance: Molecular and Biochemical Perspectives
edited by
submission deadline 31 Mar 2026 | Viewed by 86 | Submission Open
Keywords: antimicrobial resistance mechanisms; molecular basis of resistance; metabolic reprogramming in bacteria; biofilm formation and regulation; resistance gene expression and regulation
(This special issue belongs to the Section Molecular Microbiology)
Molecular Diagnosis and Treatment of Oral Cancer submission deadline 31 Mar 2026 | Viewed by 86 | Submission Open
Keywords: oral cancer; molecular diagnosis; immunophysiology; tumor microenvironment; drug resistance; oral microbiome
(This special issue belongs to the Section Molecular Oncology)
Molecular Insights into Photocatalytic Degradation and Biomass Valorization for Green Chemistry Applications
edited by
submission deadline 31 Mar 2026 | Viewed by 81 | Submission Open
Keywords: photocatalysis; advanced oxidation processes; reactive oxygen species; in operando spectroscopy; biomass valorization; lignin depolymerization; green chemistry; emerging contaminants; structure– activity relationships; water reuse and treatment
(This special issue belongs to the Section Biochemistry)
Nanomaterials in Biomedicine, Microbiology and Tissue Engineering submission deadline 31 Mar 2026 | Viewed by 81 | Submission Open
Keywords: nanomaterials; nanotechnology; biomedicine; microbiology; tissue regeneration
(This special issue belongs to the Section Materials Science)
Unraveling the Molecular Landscape of Systemic Lupus Erythematosus
edited by Yoshinori Matsumoto
submission deadline 31 Mar 2026 | Viewed by 75 | Submission Open
Keywords: systemic lupus erythematosus; autoimmunity; molecular mechanisms; immune regulation; type I interferon; biomarkers; multi-omics; signal transduction; precision medicine; targeted therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Skin Cancer: Molecular Drivers, Biomarkers, Non-Invasive Diagnostics and Therapeutic Strategies
edited by , and Giulia Veronesi
submission deadline 31 Mar 2026 | Viewed by 73 | Submission Open
Keywords: melanoma; skin cancers; immunotherapy; targeted therapy; liquid biopsy; non-invasive diagnostics techniques; miRNA; genomic
(This special issue belongs to the Section Molecular Oncology)
DNA Repair Mechanisms in Neurological Disorders
edited by Camila Araújo Bernardino Garcia
submission deadline 31 Mar 2026 | Viewed by 73 | Submission Open
Keywords: DNA repair; somatic mosaicism; focal cortical dysplasia; epilepsy genetics; cortical malformations; neurodevelopmental disorders; genomic instability; precision medicine
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Insights and Innovative Materials in Prosthodontics and Oral Implantology
edited by Ángel-Orión Salgado-Peralvo
submission deadline 31 Mar 2026 | Viewed by 68 | Submission Open
Keywords: dental implants; dental prosthesis; implant-supported; osseointegration; dental implantation; bone regeneration
(This special issue belongs to the Section Materials Science)
Advances in Immunotherapy for Cancer: From Molecular Basis to Novel Biomarkers and Therapeutic Targets—2nd Edition submission deadline 31 Mar 2026 | Viewed by 66 | Submission Open
Keywords: tumor microenvironment; immune suppression; metabolic and molecular mechanisms of resistance to therapy; tumor immune escape; immunotherapy; immune checkpoint inhibitors; cancer vaccination; tumor-infiltrating cells; biomarkers; tumor antigens; cancer metabolism
(This special issue belongs to the Section Molecular Oncology)
Recent Advances in Breast Cancer Immunology and Immunotherapy
edited by Tamara Gulić
submission deadline 31 Mar 2026 | Viewed by 64 | Submission Open
Keywords: breast cancer; immunology; tumor microenvironment; immunotherapy tumor infiltrating lymphocytes; innate immunology; immune-checkpoint inhibitors; immunotherapy; biomarkers; targeted therapies
(This special issue belongs to the Section Molecular Immunology)
Microenviromental Signalling in Tumorigenesis and Anti-Cancer Drugs Resistance
edited by
submission deadline 5 Apr 2026 | Viewed by 199 | Submission Open
Keywords: tumor microenvironment; cancer cell signaling; paracrine and autocrine mechanisms; cancer drug resistance; oncogenic pathways; immune checkpoints; cancer immune evasion; cancer-associated fibroblasts; tumor-infiltrating lymphocytes; onco-immunology; CAR-T
(This special issue belongs to the Section Molecular Oncology)
Research on Drug Delivery in Health and Disease submission deadline 10 Apr 2026 | Viewed by 65 | Submission Open
Keywords: precision medicine; nanomedicine; targeted delivery; biomarkers; personalized therapy; adaptive systems; AI-driven drug delivery
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Biology of Cancer—Implications for Diagnosis and Treatment: 3rd Edition submission deadline 20 Apr 2026 | 27 articles | Viewed by 47375 | Submission Open
Keywords: genomics; epigenetics; translational research; oncology precision medicine
(This special issue belongs to the Section Molecular Oncology)
Recent Research in Gut Microbiota–Gut–Brain Axis
edited by Ying Han
submission deadline 20 Apr 2026 | 5 articles | Viewed by 37585 | Submission Open
Keywords: microbiota; dysbiosis; microbiota– gut– brain axis; short-chain fatty acid; immune pathway; vagus nerve; neuropsychiatric disorders; depression
(This special issue belongs to the Section Molecular Biology)
New Insights in Tumor Immunity
edited by
submission deadline 20 Apr 2026 | 10 articles | Viewed by 36470 | Submission Open
Keywords: tumor immunity; tumor evolution; tumor antigens; immune surveillance; cancer immunoediting; tumor microenvironment; immunotherapies; immune checkpoints; tumor-specific lymphocytes
(This special issue belongs to the Section Molecular Immunology)
Editorial Board Members’ Collection Series: Genome Stability submission deadline 20 Apr 2026 | 7 articles | Viewed by 24211 | Submission Open
Keywords: genome stability; DNA damage response; DNA repair; DNA replication; DNA recombination; ATR/ATM pathway; GENOTOXINS
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular and Physiological Mechanisms of Exercise
edited by Zoran Nikolovski
submission deadline 20 Apr 2026 | 4 articles | Viewed by 22820 | Submission Open
Keywords: molecular biology; biochemistry and exercise; athletic performance; multi-omic
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms of Tendinopathy: Unraveling the Pathogenesis of Tendon Diseases
edited by
submission deadline 20 Apr 2026 | 2 articles | Viewed by 20372 | Submission Open
Keywords: tendinopathy; tendon pain; stiffness; physical disability; etiopathogenesis; molecular mechanisms; tendon reattachment; tendon repair; advanced molecular tools; omics techniques; biophysical therapies; novel biomaterials
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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