DNA Repair Mechanisms in Neurological Disorders

Dear Colleagues,

DNA repair mechanisms are essential for maintaining genomic stability and proper brain development. Disruption of these pathways has been increasingly recognized as a driver of neurological diseases, including epilepsy. In particular, focal cortical dysplasias (FCDs)—a leading cause of drug-resistant epilepsy treated surgically—have been linked to somatic mosaic mutations in genes related to DNA repair, chromatin remodeling, and neuronal signaling.

This Special Issue of IJMS aims to gather cutting-edge research exploring how DNA repair dysfunction contributes to neurodevelopmental abnormalities, neuronal hyperexcitability, and epileptogenesis. We welcome submissions addressing molecular, cellular, and clinical aspects of DNA repair in neurological disorders, including:

• Genetic and genomic studies identifying pathogenic variants;
• Functional analyses of DNA repair pathways in neural cells and tissues;
• Mechanistic studies on somatic mosaicism and cortical malformations;
• Translational and therapeutic insights into precision medicine for epilepsy and related.

By bridging molecular genetics and neuroscience, this collection seeks to advance our understanding of how genomic instability shapes brain function and disease.

Dr. Camila Araújo Bernardino Garcia
Guest Editor

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