DNA Repair Mechanisms in Neurological Disorders
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 15
Special Issue Editor
Interests: somatic mosaicism and brain malformations; genetic mechanisms of focal cortical dysplasia and epilepsy; dna repair and genomic instability in neurological disorders; neurogenetics and precision medicine; functional genomics and single-cell multi-omics approaches; molecular pathology of neurodevelopmental diseases
Special Issue Information
Dear Colleagues,
DNA repair mechanisms are essential for maintaining genomic stability and proper brain development. Disruption of these pathways has been increasingly recognized as a driver of neurological diseases, including epilepsy. In particular, focal cortical dysplasias (FCDs)—a leading cause of drug-resistant epilepsy treated surgically—have been linked to somatic mosaic mutations in genes related to DNA repair, chromatin remodeling, and neuronal signaling.
This Special Issue of IJMS aims to gather cutting-edge research exploring how DNA repair dysfunction contributes to neurodevelopmental abnormalities, neuronal hyperexcitability, and epileptogenesis. We welcome submissions addressing molecular, cellular, and clinical aspects of DNA repair in neurological disorders, including:
- Genetic and genomic studies identifying pathogenic variants;
- Functional analyses of DNA repair pathways in neural cells and tissues;
- Mechanistic studies on somatic mosaicism and cortical malformations;
- Translational and therapeutic insights into precision medicine for epilepsy and related.
By bridging molecular genetics and neuroscience, this collection seeks to advance our understanding of how genomic instability shapes brain function and disease.
Dr. Camila Araújo Bernardino Garcia
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- DNA repair
- somatic mosaicism
- focal cortical dysplasia
- epilepsy genetics
- cortical malformations
- neurodevelopmental disorders
- genomic instability
- precision medicine
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
