Research on the Mechanism of Ferroptosis

Dear Colleagues,

Ferroptosis is an iron-dependent, novel type of programmed cell death that is different from apoptosis and autophagy. The main mechanism of ferroptosis is that under the action of ferrous iron or esteroxygenase, it catalyzes the highly expressed unsaturated fatty acids on the cell membrane, causing lipid peroxidation, thereby inducing cell death; in addition, it is also manifested as a decrease in the regulatory core enzyme GPX4 of the antioxidant system (glutathione system).

Basic research often involves the study of various cell death modes, such as autophagy and apoptosis. Ferroptosis is a recently discovered cell death mode. At present, its morphology, biology, and mechanism pathways are partially understood, but the ferroptosis process involves multiple mechanisms and is precisely regulated by signal pathways. Therefore, further research on the mechanism of ferroptosis and its role in different types of diseases is important for finding therapeutic targets for related diseases and research on targeted drugs.

Prof. Dr. Rita Rezzani
Dr. Gaia Favero
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.