Drug Resistance Mechanisms in Human Cancer Cells to Anticancer Drugs
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: 20 September 2025 | Viewed by 436
Special Issue Editor
Interests: DNA chemistry; Drug-DNA interaction; G-quadruplex-interactive drugs; anticancer drug discovery; mechanism of actions of new anticancer drugs; transcription factors; DNA repair
Special Issue Information
Dear Colleagues,
The development of resistance to anticancer agents within human cancer cells remains an important area of scientific and clinical investigation. Cancer cells acquire resistance through various mechanisms. New capabilities for repairing DNA damage can arise in response to cytotoxic therapies. Targeted therapies may lose their efficacy due to mutations in the target proteins or epigenetic changes in the expression levels. Cancer cells may even develop mechanisms to inactivate drugs directly. Additionally, resistance arises over time as a result of new mutations. Even as some cells within a tumour remain susceptible to a given treatment, other cells may develop resistance and persist. As a result, a therapeutic strategy that is of interest in new cancer drug development is the use of small molecule inhibitors to target drug resistance mechanisms. This Special Issue, “Drug Resistance Mechanisms in Human Cancer Cells to Anticancer Drugs”, welcomes original research and review articles in the field with a focus on, but not limited to, the molecular and mechanistic basis for drug resistance mechanisms in human cancer cells, as well as new therapeutic strategies for countering these resistance mechanisms.
Dr. Daekyu Sun
Guest Editor
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Keywords
- cancer therapy
- targeted therapy
- combination therapy
- drug resistance
- resensitization
- DNA repair
- DNA damage response
- DNA repair inhibitors
- synthetic lethality
- chemoradiation
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